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KEGG   Homo sapiens (human): 762
Entry
762               CDS       T01001                                 
Symbol
CA4, CAIV, Car4, RP17
Name
(RefSeq) carbonic anhydrase 4
  KO
K18246  carbonic anhydrase 4 [EC:4.2.1.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00910  Nitrogen metabolism
hsa01100  Metabolic pathways
hsa04964  Proximal tubule bicarbonate reclamation
Disease
H00527  Retinitis pigmentosa
Drug target
Acetazolamide (DG01134): D00218<JP/US> D01196<JP/US>
Clofenamide: D01822
Diclofenamide: D00518<US>
Dorzolamide (DG01135): D00653<JP/US> D07871
Ethoxzolamide: D02441
Methazolamide: D00655<US>
Sezolamide hydrochloride: D03845
Topiramate: D00537<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00910 Nitrogen metabolism
    762 (CA4)
 09150 Organismal Systems
  09155 Excretory system
   04964 Proximal tubule bicarbonate reclamation
    762 (CA4)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    762 (CA4)
   00537 Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:hsa00537]
    762 (CA4)
Enzymes [BR:hsa01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.1  carbonic anhydrase
     762 (CA4)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   762 (CA4)
Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:hsa00537]
 Enzymes
  762 (CA4)
SSDB
Motif
Pfam: Carb_anhydrase
Other DBs
NCBI-GeneID: 762
NCBI-ProteinID: NP_000708
OMIM: 114760
HGNC: 1375
Ensembl: ENSG00000167434
UniProt: P22748
Structure
Position
17:60149973..60179021
AA seq 312 aa
MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTK
AKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSD
LPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGF
QPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFRE
PIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLG
PMLACLLAGFLR
NT seq 939 nt   +upstreamnt  +downstreamnt
atgcggatgctgctggcgctcctggccctctccgcggcgcggccatcggccagtgcagag
tcacactggtgctacgaggttcaagccgagtcctccaactacccctgcttggtgccagtc
aagtggggtggaaactgccagaaggaccgccagtcccccatcaacatcgtcaccaccaag
gcaaaggtggacaaaaaactgggacgcttcttcttctctggctacgataagaagcaaacg
tggactgtccaaaataacgggcactcagtgatgatgttgctggagaacaaggccagcatt
tctggaggaggactgcctgccccataccaggccaaacagttgcacctgcactggtccgac
ttgccatataagggctcggagcacagcctcgatggggagcactttgccatggagatgcac
atagtacatgagaaagagaaggggacatcgaggaatgtgaaagaggcccaggaccctgaa
gacgaaattgcggtgctggcctttctggtggaggctggaacccaggtgaacgagggcttc
cagccactggtggaggcactgtctaatatccccaaacctgagatgagcactacgatggca
gagagcagcctgttggacctgctccccaaggaggagaaactgaggcactacttccgctac
ctgggctcactcaccacaccgacctgcgatgagaaggtcgtctggactgtgttccgggag
cccattcagcttcacagagaacagatcctggcattctctcagaagctgtactacgacaag
gaacagacagtgagcatgaaggacaatgtcaggcccctgcagcagctggggcagcgcacg
gtgataaagtccggggccccgggtcggccgctgccctgggccctgcctgccctgctgggc
cccatgctggcctgcctgctggccggcttcctgcgatga

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (3)   
   KEGG PATHWAY (3)   
Disease (2)   
   KEGG DISEASE (1)   
   OMIM (1)   
Drug (10)   
   KEGG DRUG (10)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (31)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (21)   
   OC (1)   
Protein sequence (21)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (19)   
DNA sequence (38)   
   RefSeq(nuc) (20)   
   GenBank (9)   
   EMBL (9)   
3D Structure (10)   
   PDB (10)   
Protein domain (1)   
   Pfam (1)   
All databases (127)   

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