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KEGG   Dasypus novemcinctus (nine-banded armadillo): 101428386
Entry
101428386         CDS       T07872                                 
Symbol
PLCG2
Name
(RefSeq) LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
  KO
K05859  phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
Organism
dnm  Dasypus novemcinctus (nine-banded armadillo)
Pathway
dnm00562  Inositol phosphate metabolism
dnm01100  Metabolic pathways
dnm01521  EGFR tyrosine kinase inhibitor resistance
dnm04012  ErbB signaling pathway
dnm04014  Ras signaling pathway
dnm04020  Calcium signaling pathway
dnm04062  Chemokine signaling pathway
dnm04064  NF-kappa B signaling pathway
dnm04066  HIF-1 signaling pathway
dnm04070  Phosphatidylinositol signaling system
dnm04072  Phospholipase D signaling pathway
dnm04360  Axon guidance
dnm04370  VEGF signaling pathway
dnm04380  Osteoclast differentiation
dnm04611  Platelet activation
dnm04613  Neutrophil extracellular trap formation
dnm04625  C-type lectin receptor signaling pathway
dnm04650  Natural killer cell mediated cytotoxicity
dnm04662  B cell receptor signaling pathway
dnm04664  Fc epsilon RI signaling pathway
dnm04666  Fc gamma R-mediated phagocytosis
dnm04670  Leukocyte transendothelial migration
dnm04722  Neurotrophin signaling pathway
dnm04750  Inflammatory mediator regulation of TRP channels
dnm04919  Thyroid hormone signaling pathway
dnm04933  AGE-RAGE signaling pathway in diabetic complications
dnm04935  Growth hormone synthesis, secretion and action
dnm05167  Kaposi sarcoma-associated herpesvirus infection
dnm05169  Epstein-Barr virus infection
dnm05170  Human immunodeficiency virus 1 infection
dnm05171  Coronavirus disease - COVID-19
dnm05200  Pathways in cancer
dnm05205  Proteoglycans in cancer
dnm05206  MicroRNAs in cancer
dnm05214  Glioma
dnm05223  Non-small cell lung cancer
dnm05225  Hepatocellular carcinoma
Module
dnm_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:dnm00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    101428386 (PLCG2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    101428386 (PLCG2)
   04064 NF-kappa B signaling pathway
    101428386 (PLCG2)
   04066 HIF-1 signaling pathway
    101428386 (PLCG2)
   04070 Phosphatidylinositol signaling system
    101428386 (PLCG2)
   04072 Phospholipase D signaling pathway
    101428386 (PLCG2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    101428386 (PLCG2)
   04613 Neutrophil extracellular trap formation
    101428386 (PLCG2)
   04650 Natural killer cell mediated cytotoxicity
    101428386 (PLCG2)
   04662 B cell receptor signaling pathway
    101428386 (PLCG2)
   04664 Fc epsilon RI signaling pathway
    101428386 (PLCG2)
   04666 Fc gamma R-mediated phagocytosis
    101428386 (PLCG2)
   04670 Leukocyte transendothelial migration
    101428386 (PLCG2)
   04062 Chemokine signaling pathway
    101428386 (PLCG2)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    101428386 (PLCG2)
   04919 Thyroid hormone signaling pathway
    101428386 (PLCG2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    101428386 (PLCG2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    101428386 (PLCG2)
  09158 Development and regeneration
   04360 Axon guidance
    101428386 (PLCG2)
   04380 Osteoclast differentiation
    101428386 (PLCG2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101428386 (PLCG2)
   05206 MicroRNAs in cancer
    101428386 (PLCG2)
   05205 Proteoglycans in cancer
    101428386 (PLCG2)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    101428386 (PLCG2)
   05214 Glioma
    101428386 (PLCG2)
   05223 Non-small cell lung cancer
    101428386 (PLCG2)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    101428386 (PLCG2)
   05171 Coronavirus disease - COVID-19
    101428386 (PLCG2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    101428386 (PLCG2)
   05169 Epstein-Barr virus infection
    101428386 (PLCG2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    101428386 (PLCG2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101428386 (PLCG2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:dnm04131]
    101428386 (PLCG2)
Enzymes [BR:dnm01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     101428386 (PLCG2)
Membrane trafficking [BR:dnm04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    101428386 (PLCG2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    101428386 (PLCG2)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 C2 SH3_1 PH SH3_9 PH_12 EF-hand_PLCG1 SH2_1 PH_14 SH3_2 GDPD EF-hand_like Adhesin_E
Other DBs
NCBI-GeneID: 101428386
NCBI-ProteinID: XP_004469006
Ensembl: ENSDNOG00000001166
Position
Unknown
AA seq 1262 aa
MATVDSLPEYEKSQIKRALELGTVMSVFSFRKYTPERRTVQVVMETRQVAWSKTADKIEG
FLDIMEIKEIRPGKCSKDFDRAKTVRQKEDCCFTILYGTQFVLSTLSLAADSKEDADKWL
SGLKILHQEAMSASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLVNFKVSSAKFL
KDKFVEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASAVHL
HDFQRFLLHEQQELWAQDLSKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENSIWD
ERYDMVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSTEAYIRCLRMGCRCIELDCWDG
PDGKPIIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCCVEQQRYMARVFKE
VFGDQLLVKPTEASADQLPSPSQLREKVIIKHKKLGPRGDVDINVEDKKDEHKQQGELYM
WDSIDQKWTRHYCAIADAKLSFSDDIEQTVEEEAPQDIPPTELHFGEKWFHKKVEKRTSA
EKLLQEYCAETGGKDGTFLVRESESFPNKYTLSFWRSGRVQHCLIRSTMEGGSLKYYLTD
NLLFSSVYALIQHYRESHLRCAEFELRLTDPVPNPNPHESQPWYYDGLSRGEAEDMLMRI
PRDGAFLIRKREGADSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYYEKH
ALYRKMXLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEISPSMPQRTVKALYDYKAK
QSDELSFCRGALIHNVSKEPGGWWKGDYGARIQQYFPSNYVEDISTVDVEELEKQIIEDN
PLGSLCRGILDLNTYNVVKTPQGKNQKPFVFILEPKKQGDPPVEFATDKVEELFEWFQSI
REITWKIDTKENSMRYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVETKA
DSIVRQKPIDLLKYNQKGLTRIYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQV
NHALFSLNGRTGYVLQPEGMRGEKYDPMPPESQRKIRMTLTVKVLGARHLPKPGRSIACP
FVEVEICGAEYDNNKFKTTVVNDNGLSPVWAATQEKVTFEIYDPNLAFLRFVVYEEDMFS
DPNFLAHATYPIKGIKSGFRAVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSCRQL
RRRQEELNNQLFLYDTHQNLRNANRDALVREFNVNENQLQLCQEKCNRRLREKRVSNSKF
YS
NT seq 3789 nt   +upstreamnt  +downstreamnt
atggcgaccgtggacagccttccggagtatgagaagagccagatcaagagagccctggag
ctgggcacggtgatgtccgtgttcagtttccgcaagtacacgcccgagcggaggacggtg
caggtggtcatggagacccggcaggtggcgtggagcaagaccgccgacaagattgagggc
ttcctggacatcatggaaataaaggaaatccgcccagggaagtgctccaaggattttgac
cgtgcaaaaaccgtccgccagaaagaagactgctgcttcacgattctgtacggcacccag
ttcgtcctcagcacactaagcttagcagctgactctaaagaggatgcagacaagtggctt
tctggcctgaagatcttacaccaagaagcaatgagtgcatctactcccacgattatcgag
agttggctgaggaagcagatttattctgtggatcaaaccagaagaaacagcatcagcctc
cgggagttgaagaccatcctgcccctggtcaacttcaaagtcagcagtgccaagttcctc
aaagacaagttcgtggaaataggcgctcacaaagatgaactcagctttgagcagttccat
ctcttctataaaaagcttatgtttgaacagcaaaaatcgattcttgatgaattcaagaaa
gactcgtccgtgttcatcttggggaacaccgaccggcccgatgcctccgctgtgcacctg
cacgacttccagaggtttctcttacacgagcagcaggagctttgggctcaggatctgagc
aaagtccgggagcggatgacaaagtttattgatgatacgatgagggaaacggctgagccc
ttcttgtttgttgacgagttcctcacctacctgttttcacgagaaaacagcatttgggac
gagaggtacgacatggtggacatgcaggacatgaacaaccccttgtcgcattactggatc
tcctcgtcacacaacacgtacctcacaggggaccagctgcggagcgagtcgtccacggag
gcgtacatccgctgcctgcgcatgggctgccgctgcattgagctggactgctgggacggg
ccagacgggaagcccatcatctaccacggctggacgcggaccaccaagatcaagtttgac
gatgtcgtgcaggccatcaaggaccacgccttcgtcacctcgagcttccctgtgatcctg
tccatcgaggagcactgctgcgtggagcagcagcgctacatggccagggtgttcaaggag
gtgtttggagaccagctgcttgtgaagcccacggaggccagcgccgaccagctgccctca
cccagccagctgcgggagaaggtcatcatcaagcacaagaagctgggcccccgaggtgac
gtggacatcaacgtggaagacaagaaggatgagcacaagcagcagggcgaactgtacatg
tgggattccattgaccagaaatggactcggcactactgcgccatcgccgacgccaagctt
tccttcagtgacgacatcgagcagaccgtagaagaggaagcgccccaggacatccccccc
acggagctgcattttggggagaagtggttccacaaaaaggtggagaagaggacgagcgcc
gagaagctgctgcaggagtactgcgccgagacggggggcaaggacgggaccttcctggtg
cgggagagcgagtccttccccaacaagtacaccctgtccttctggcggtcgggccgggtc
cagcactgcctcatccgctccaccatggagggcgggagcctgaagtactacctgactgac
aacctgctcttcagcagcgtctacgcgctcatccagcactaccgcgagagccacctgcgc
tgcgccgagttcgagctgcgcctcaccgaccccgtgcccaaccccaacccgcacgagtcc
cagccgtggtactacgatgggctgagccgtggcgaggcggaggacatgctgatgcggatc
ccccgcgatggggccttcctgatccggaagcgggaaggcgccgactcctacgccatcacc
ttcagggccaggggcaaggtcaagcactgccgcatcaaccgggacggccggcacttcgtg
ctgggcacctccgcctacttcgagagcctggtggagctggtcagctactacgagaagcac
gccctctaccggaagatgnagctgcgctaccccgtgacccccgagctcctggagcgctac
aatatggaaagagatataaactccctctatgacgtcagccgaatgtatgtggatccgagc
gaaatcagtccttccatgcctcagagaaccgtgaaagcgctgtacgactacaaggccaag
caaagcgatgagctgagcttctgtcgtggcgccctcatccacaacgtctccaaggagccc
gggggctggtggaaaggagactacggggccagaatccagcagtacttcccgtcgaattac
gttgaggacatttccacagtcgacgtcgaggagctggagaagcagattatcgaagacaat
cccttagggtctctctgcagaggaatattggacctcaatacttataacgtggtgaaaacc
ccgcaagggaaaaaccagaagcctttcgtctttatcctggagcctaagaagcagggtgac
cctccggtggagttcgccacggacaaggtggaggagctgtttgagtggttccagagcatc
cgggagatcacctggaagattgacaccaaggagaacagcatgaggtactgggagaagaac
cagtcgatcgccatcgagctctcggacctggtcgtctactgcaaacctaccagcaagacc
aaggacaacttagaaaaccctgacttccgagagatccgctccttcgtggagaccaaggct
gacagcatcgtcaggcagaaacccatcgatctcttgaagtacaaccaaaagggcctgacc
cgcatctacccgaaggggcagagggtcgactcgtcaaactacgatcccttccgcctctgg
ctgtgtggctcacagatggtggccctcaacttccagactgcagataagtacatgcaggtg
aaccacgccctgttttccctcaatgggcggacgggctacgtcctgcagccagagggcatg
aggggggagaagtacgaccccatgcctccggagtcccagaggaagatccggatgacgctg
accgtcaaggttctcggtgcccgccatctccccaagcctggacggagcatcgcttgtccg
tttgtcgaggtggaaatatgtggtgccgagtacgacaacaacaagtttaagacaacagtt
gtgaatgacaatggcttaagccctgtctgggctgcaacacaggagaaggtgacatttgaa
atttatgacccaaacctcgcatttctgcgcttcgtggtatacgaggaagatatgttcagc
gatcccaactttctggctcatgccacttaccccattaaaggaatcaagtcaggatttaga
gctgttcctctcaagaatggatacagtgaagacattgagctggcttcccttctggttttc
tgtgagatgcggccagtgctggagagcgaggaggagctttactcctcctgccgccagctg
cgcagacggcaggaggagctgaacaaccagctttttctatatgacacgcaccagaacttg
cgcaatgccaaccgggatgccctcgtcagagagttcaatgtcaacgagaaccagctccag
ctgtgccaggagaagtgcaaccggaggttgagggagaagagagtcagcaacagcaagttt
tactcatag

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (38)   
   KEGG PATHWAY (37)   
   KEGG MODULE (1)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
Protein sequence (2)   
   RefSeq(pep) (2)   
DNA sequence (2)   
   RefSeq(nuc) (2)   
Protein domain (16)   
   Pfam (16)   
All databases (78)   

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