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KEGG   Chlorocebus sabaeus (green monkey): 103233371
Entry
103233371         CDS       T04361                                 
Symbol
PLCG2
Name
(RefSeq) phospholipase C gamma 2
  KO
K05859  phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
Organism
csab  Chlorocebus sabaeus (green monkey)
Pathway
csab00562  Inositol phosphate metabolism
csab01100  Metabolic pathways
csab01521  EGFR tyrosine kinase inhibitor resistance
csab04012  ErbB signaling pathway
csab04014  Ras signaling pathway
csab04020  Calcium signaling pathway
csab04062  Chemokine signaling pathway
csab04064  NF-kappa B signaling pathway
csab04066  HIF-1 signaling pathway
csab04070  Phosphatidylinositol signaling system
csab04072  Phospholipase D signaling pathway
csab04360  Axon guidance
csab04370  VEGF signaling pathway
csab04380  Osteoclast differentiation
csab04611  Platelet activation
csab04613  Neutrophil extracellular trap formation
csab04625  C-type lectin receptor signaling pathway
csab04650  Natural killer cell mediated cytotoxicity
csab04662  B cell receptor signaling pathway
csab04664  Fc epsilon RI signaling pathway
csab04666  Fc gamma R-mediated phagocytosis
csab04670  Leukocyte transendothelial migration
csab04722  Neurotrophin signaling pathway
csab04750  Inflammatory mediator regulation of TRP channels
csab04919  Thyroid hormone signaling pathway
csab04933  AGE-RAGE signaling pathway in diabetic complications
csab04935  Growth hormone synthesis, secretion and action
csab05167  Kaposi sarcoma-associated herpesvirus infection
csab05169  Epstein-Barr virus infection
csab05170  Human immunodeficiency virus 1 infection
csab05171  Coronavirus disease - COVID-19
csab05200  Pathways in cancer
csab05205  Proteoglycans in cancer
csab05206  MicroRNAs in cancer
csab05214  Glioma
csab05223  Non-small cell lung cancer
csab05225  Hepatocellular carcinoma
Module
csab_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:csab00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    103233371 (PLCG2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    103233371 (PLCG2)
   04064 NF-kappa B signaling pathway
    103233371 (PLCG2)
   04066 HIF-1 signaling pathway
    103233371 (PLCG2)
   04070 Phosphatidylinositol signaling system
    103233371 (PLCG2)
   04072 Phospholipase D signaling pathway
    103233371 (PLCG2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    103233371 (PLCG2)
   04613 Neutrophil extracellular trap formation
    103233371 (PLCG2)
   04650 Natural killer cell mediated cytotoxicity
    103233371 (PLCG2)
   04662 B cell receptor signaling pathway
    103233371 (PLCG2)
   04664 Fc epsilon RI signaling pathway
    103233371 (PLCG2)
   04666 Fc gamma R-mediated phagocytosis
    103233371 (PLCG2)
   04670 Leukocyte transendothelial migration
    103233371 (PLCG2)
   04062 Chemokine signaling pathway
    103233371 (PLCG2)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    103233371 (PLCG2)
   04919 Thyroid hormone signaling pathway
    103233371 (PLCG2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    103233371 (PLCG2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    103233371 (PLCG2)
  09158 Development and regeneration
   04360 Axon guidance
    103233371 (PLCG2)
   04380 Osteoclast differentiation
    103233371 (PLCG2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103233371 (PLCG2)
   05206 MicroRNAs in cancer
    103233371 (PLCG2)
   05205 Proteoglycans in cancer
    103233371 (PLCG2)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    103233371 (PLCG2)
   05214 Glioma
    103233371 (PLCG2)
   05223 Non-small cell lung cancer
    103233371 (PLCG2)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    103233371 (PLCG2)
   05171 Coronavirus disease - COVID-19
    103233371 (PLCG2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    103233371 (PLCG2)
   05169 Epstein-Barr virus infection
    103233371 (PLCG2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    103233371 (PLCG2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    103233371 (PLCG2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:csab04131]
    103233371 (PLCG2)
Enzymes [BR:csab01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     103233371 (PLCG2)
Membrane trafficking [BR:csab04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    103233371 (PLCG2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    103233371 (PLCG2)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 SH3_1 C2 SH3_9 PH PH_12 EF-hand_PLCG1 SH2_1 SH3_2 PH_14 EF-hand_like
Other DBs
NCBI-GeneID: 103233371
NCBI-ProteinID: XP_007992373
Ensembl: ENSCSAG00000003427
UniProt: A0A0D9S186
Position
5:67209268..67394865
AA seq 1265 aa
MSTMVNVDSLAEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADK
IEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLNTLSLAADSKEDAL
NWLSGLKILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLINFKVSSA
KFLKDKFVEIGAHRDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASA
IYLHDFQRFLIHEQQEHWAQDLSKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENS
IWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDC
WDGPDGKPIIYHGWTRTTKIKFDDVVQAIKEHAFVTSSFPVILSIEEHCSVEQQRHMAKT
FKEVFGDLLLMKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNVEDKKDEHKQQGE
LYMWDSIDQKWTRHYCAVADAKLSFSDDIEQTTEEEVPQDIPPTELHFGEKWFHKKVEKR
TSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTTEGGTLKYY
LTDNLTFSSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYESLSRGEAEDML
MRIPRDGAFLIRKREGSDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYY
EKHSLYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDY
KAKRSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISTADVEELEKQII
EDNPLGSLCRGILDLNTYNVVKAPQGKNQKPFVFILEPKKQGDPPVEFATDRVEELFEWF
QSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVE
TKADSITRQKPVDLLRYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKF
MQMNHALFSLNGRTGYVLQPESMRAEKYDPMPPESQRKILMTLTVKVLGARHLPKLGRSI
ACPFVEVEICGADYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEED
MFSDPNFLAHATYPIKAIKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSC
RQLRRRQEELNNQLFLYDTHQNLRNANRDALVKEFNVNENQLQLYQEKCNKRLREKRVSN
SKFYS
NT seq 3798 nt   +upstreamnt  +downstreamnt
atgtccaccatggtcaatgtggattcccttgcggaatatgagaagagccagatcaagaga
gccctggagctggggacggtgatgactgtgttcagcttccgcaagtccacccctgagcgg
aggaccgtccaggtgatcatggagacacggcaggtggcctggagcaagaccgctgacaag
atcgagggcttcttggatatcatggaaataaaagaaatccgcccagggaagaactccaaa
gatttcgaacgtgcaaaagcggttcgccagaaagaagattgctgcttcaccatcctgtat
ggcactcagttcgtcctcaacacactcagcttggcagctgactctaaagaggatgcactt
aattggctctccggcttgaaaatcttacaccaagaagcgatgaatgcgtccacacccacc
attatcgagagttggctgagaaagcagatatattctgtggatcaaactagaagaaacagc
atcagtctccgagagctgaagaccatcttgcccctgatcaactttaaagtgagcagtgcc
aagttccttaaagataagtttgtggaaataggagcacacagagatgagctcagctttgaa
cagttccatctcttctataaaaaacttatgttcgagcagcaaaaatcgattctcgatgaa
ttcaaaaaggattcgtccgtgttcatcctggggaacacagacaggccggatgcctccgct
atttacctgcatgacttccagaggtttctcatacatgaacagcaggagcattgggctcag
gatctgagcaaagttcgtgagcggatgacaaagttcatcgatgacaccatgcgcgaaact
gctgagcctttcttgtttgtggatgagttcctcacgtacctgttttcacgagaaaacagc
atctgggatgagaagtatgacgcggtggacatgcaggacatgaacaaccccctgtctcat
tactggatctcctcgtcacataacacgtacctcacaggtgaccagctgcggagcgagtcg
tccccggaagcttacatccgctgcctgcgcatgggctgtcgctgcattgaactggactgc
tgggacgggcccgatgggaagcccatcatctaccacggctggacgcggaccaccaagatc
aagtttgacgacgtcgtacaggccatcaaagagcacgcctttgttacctcaagcttccca
gtgatcctgtccatcgaggagcactgcagtgtggagcagcagcgtcacatggccaagacc
ttcaaggaagtgtttggcgacctgctgctgatgaagcccacggaggccagcgctgaccag
ctgccctcgcccagccagctgcgggagaagatcatcatcaagcataagaaactgggtccc
cgaggcgacgtggatgtcaacgtggaggacaagaaggatgagcacaagcaacagggagag
ctgtacatgtgggattccattgaccagaaatggactcggcactactgcgccgttgccgat
gccaagctgtccttcagtgatgacattgaacagactacggaggaggaagtgccccaggat
ataccccctacagagctacattttggggagaaatggttccacaagaaggtggagaagagg
acgagtgccgagaagttgctgcaggaatactgcatggagacggggggcaaggacggcacc
ttcctggttcgggagagcgagaccttccccaatgactacaccctgtccttctggcggtca
ggccgggtccagcactgccggatccgttccaccacggagggtggaaccctgaagtactac
ctgactgacaacctcaccttcagcagcatctacgccctcatccagcactaccgcgagacg
cacctgcgctgcgccgagttcgagctgcggctcacggaccctgtgcccaaccccaacccc
cacgagtccaagccgtggtactatgagagcctgagccgcggagaggcagaggacatgctg
atgaggatcccccgggacggagccttcctgatccggaagcgagagggaagcgactcctac
gccatcaccttcagggctaggggcaaggtgaagcattgtcgaatcaaccgggatggccgg
cactttgtgctggggacctccgcctattttgagagcctggtggagctcgtcagttactac
gagaagcattcactctaccgaaagatgagactgcgctaccccgtgacccccgagctcctg
gagcgctacaacatggaaagagatataaactccctctacgacgtcagcagaatgtatgtg
gatcccagtgaaatcaatccatccatgcctcagagaaccgtgaaagctctgtatgactac
aaagccaagcgaagcgatgagctgagcttctgccgtggcgctctcatccacaatgtctcc
aaggagcccgggggctggtggaaaggagactatggaaccaggatccagcagtacttccca
tccaactacgtcgaggacatctcaacggcagatgtcgaggagctggaaaagcagattatt
gaagacaatcccttagggtctctttgcagaggaatattggacctcaatacctataacgtc
gtgaaagccccacagggaaaaaaccagaagccctttgtcttcatcctggagcccaagaag
cagggcgatcctccggtggagtttgccacagacagggtggaggagctcttcgagtggttt
cagagcatccgagagatcacctggaagattgacaccaaggagaacaacatgaagtactgg
gagaagaaccagtccatcgccatcgagctctctgacctggttgtctactgcaaaccaacc
agcaaaaccaaggacaacttagaaaatcctgatttccgagaaatccgctcctttgtggaa
acgaaggctgacagcatcaccagacagaagcccgtcgacctcctgaggtataatcaaaag
ggcctgacccgcgtctacccaaagggacaaagagttgactcttcaaactacgaccccttc
cgcctctggctgtgcggttctcagatggtggcactcaatttccagacggcagataagttc
atgcagatgaatcacgcgttgttttctctcaatgggcgcacgggctacgttctgcagccc
gagagcatgagggcagagaaatatgacccaatgccacccgagtcccagaggaagatcctg
atgacgctgacggtcaaggttctcggtgctcgccatctccccaaacttggacgaagtatt
gcctgtccctttgtagaggtggagatctgtggagccgactatgacaacaacaagttcaag
acgacggttgtgaatgataatggcctcagccctatctgggctccaacacaggagaaggtg
acatttgaaatttatgacccaaacctggcatttctgcgctttgtggtttacgaagaagat
atgttcagtgatcccaactttcttgctcatgccacttaccccattaaagcaatcaaatca
ggattcaggtctgttcctctgaagaatgggtacagcgaggacatagagctggcttccctc
ctggttttctgtgagatgcggccagtcctggagagcgaagaggaactttactcctcctgt
cgccagctaaggaggcggcaagaagaactgaacaaccaactctttctgtatgacacacac
cagaacttgcgcaatgccaaccgggatgccctggttaaagagttcaatgttaatgagaac
cagctccagctgtaccaggagaaatgcaacaagaggttaagagagaagagagtcagcaac
agcaagttttactcatag

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