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KEGG   Bos mutus (wild yak): 102285300
Entry
102285300         CDS       T02919                                 
Symbol
PLCG2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
  KO
K05859  phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
Organism
bom  Bos mutus (wild yak)
Pathway
bom00562  Inositol phosphate metabolism
bom01100  Metabolic pathways
bom01521  EGFR tyrosine kinase inhibitor resistance
bom04012  ErbB signaling pathway
bom04014  Ras signaling pathway
bom04020  Calcium signaling pathway
bom04062  Chemokine signaling pathway
bom04064  NF-kappa B signaling pathway
bom04066  HIF-1 signaling pathway
bom04070  Phosphatidylinositol signaling system
bom04072  Phospholipase D signaling pathway
bom04360  Axon guidance
bom04370  VEGF signaling pathway
bom04380  Osteoclast differentiation
bom04611  Platelet activation
bom04613  Neutrophil extracellular trap formation
bom04625  C-type lectin receptor signaling pathway
bom04650  Natural killer cell mediated cytotoxicity
bom04662  B cell receptor signaling pathway
bom04664  Fc epsilon RI signaling pathway
bom04666  Fc gamma R-mediated phagocytosis
bom04670  Leukocyte transendothelial migration
bom04722  Neurotrophin signaling pathway
bom04750  Inflammatory mediator regulation of TRP channels
bom04919  Thyroid hormone signaling pathway
bom04933  AGE-RAGE signaling pathway in diabetic complications
bom04935  Growth hormone synthesis, secretion and action
bom05167  Kaposi sarcoma-associated herpesvirus infection
bom05169  Epstein-Barr virus infection
bom05170  Human immunodeficiency virus 1 infection
bom05171  Coronavirus disease - COVID-19
bom05200  Pathways in cancer
bom05205  Proteoglycans in cancer
bom05206  MicroRNAs in cancer
bom05214  Glioma
bom05223  Non-small cell lung cancer
bom05225  Hepatocellular carcinoma
Module
bom_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:bom00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    102285300 (PLCG2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    102285300 (PLCG2)
   04064 NF-kappa B signaling pathway
    102285300 (PLCG2)
   04066 HIF-1 signaling pathway
    102285300 (PLCG2)
   04070 Phosphatidylinositol signaling system
    102285300 (PLCG2)
   04072 Phospholipase D signaling pathway
    102285300 (PLCG2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    102285300 (PLCG2)
   04613 Neutrophil extracellular trap formation
    102285300 (PLCG2)
   04650 Natural killer cell mediated cytotoxicity
    102285300 (PLCG2)
   04662 B cell receptor signaling pathway
    102285300 (PLCG2)
   04664 Fc epsilon RI signaling pathway
    102285300 (PLCG2)
   04666 Fc gamma R-mediated phagocytosis
    102285300 (PLCG2)
   04670 Leukocyte transendothelial migration
    102285300 (PLCG2)
   04062 Chemokine signaling pathway
    102285300 (PLCG2)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    102285300 (PLCG2)
   04919 Thyroid hormone signaling pathway
    102285300 (PLCG2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    102285300 (PLCG2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    102285300 (PLCG2)
  09158 Development and regeneration
   04360 Axon guidance
    102285300 (PLCG2)
   04380 Osteoclast differentiation
    102285300 (PLCG2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102285300 (PLCG2)
   05206 MicroRNAs in cancer
    102285300 (PLCG2)
   05205 Proteoglycans in cancer
    102285300 (PLCG2)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    102285300 (PLCG2)
   05214 Glioma
    102285300 (PLCG2)
   05223 Non-small cell lung cancer
    102285300 (PLCG2)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    102285300 (PLCG2)
   05171 Coronavirus disease - COVID-19
    102285300 (PLCG2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102285300 (PLCG2)
   05169 Epstein-Barr virus infection
    102285300 (PLCG2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    102285300 (PLCG2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102285300 (PLCG2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:bom04131]
    102285300 (PLCG2)
Enzymes [BR:bom01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     102285300 (PLCG2)
Membrane trafficking [BR:bom04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    102285300 (PLCG2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    102285300 (PLCG2)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 C2 SH3_1 SH3_9 PH EF-hand_PLCG1 PH_12 SH2_1 SH3_2 PH_14 EF-hand_like GDPD
Other DBs
NCBI-GeneID: 102285300
NCBI-ProteinID: XP_070244755
Position
18:complement(54164783..54324766)
AA seq 1262 aa
MANVDTLPEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADKIEG
FLDIMEIKEIRPGKSSKDFERAKAVRQKEECCFTVLYGSQFILSTLSLAADSKEDAAKWL
SGLKILHQEVMSASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLVNFKVSSAKFL
KDKFLEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFLLGNTDRPDASAVHL
HDFQRFLLHEQQELWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENSIWD
EKYDVVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSTEAYIRCLRMGCRCIELDCWDG
PDGKPIIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCCVEQQRHMARVFKE
VFGDLLLTKPKEASADQLPSPSQLRGKIIIKHKKLGPRGDVDVNMEDKKDEHKQQGELHM
WDPIDQKWTRHYCAVADAKLSFSDDIEQTVEEELPLDIPPTELHFGEKWFHKKVEKRTSA
EKLLQEYCAETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTMKYYLTD
NLMFTSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDGLSRGEAEDMLMRI
PRDGAFLIRKREGTDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYYEKH
ALYRKMKLRYPVTPELLERYNTERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDYRAK
QSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISPTEGEEVDKQIIEDN
PLGSLCRGILNLNIYNVVKAPHGKNQKPFVFILEPKKQGDPPVEFATDSVEELFEWFQSI
REITWKMDAKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVETKA
DSIVRQKPSDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTPDKYMQM
NHALFSLNGRTGYVLQPESMRAEKYDPMPPESQRKIQMTLTVKVLGARHLPKPGRSIACP
FVEVEICGAEYDSNKFKTTVVNDNGLSPVWTPTQEKVTFEIYDPNLAFLRFVVYEEDMFS
DPNFLAHATYPIKGIKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSCRQL
RRRQEELNNQLFLYDTHQNLRSATRDALVREFNVNENQLQLYQEKCNRRLREKRVSNSKF
YS
NT seq 3789 nt   +upstreamnt  +downstreamnt
atggccaacgtggacaccctcccggagtacgagaagagtcagatcaagcgggccctggag
ctgggcaccgtcatgaccgtgttcagcttccgcaagtccaccccggagcggaggaccgtc
caggtgatcatggagacgcggcaggtggcctggagcaagacggccgacaagatcgagggc
ttcctggacatcatggagataaaggagatccggccggggaagagctccaaggatttcgag
cgcgcgaaagcggtccgccagaaggaagaatgctgcttcaccgtcctgtacggctcccag
tttatcctcagcacgctcagcctggcagccgactcgaaggaggatgccgctaagtggctg
tctggcctgaagatcttacaccaggaagtgatgagcgcgtccacccccaccatcatcgag
agctggctgagaaagcagatttattctgtggatcaaaccaggagaaacagcatcagcctc
cgggagttgaagaccatcttgcctctggtcaacttcaaagtgagcagtgccaagttcctc
aaagataagttcctggaaataggcgcacacaaagatgaactcagctttgaacagttccat
ctcttctataaaaaacttatgtttgaacagcaaaaatcgatccttgacgaattcaaaaag
gattcctccgtgttcctcttgggcaacaccgaccggccagacgcctctgctgtccacctg
cacgacttccagcggtttctcttgcatgaacagcaggagctttgggctcaggatctgaac
aaagtccgtgagcggatgacgaagtttattgacgacaccatgagggaaactgctgaaccc
ttcctgtttgtggatgagttcctcacgtacctgttttcccgggagaacagcatctgggac
gaaaagtacgacgtggtggacatgcaggacatgaacaaccccttgtctcattactggatc
tcctcgtctcacaacacgtacctcacgggggaccagctgcggagcgagtcgtccacggag
gcctacatccgctgcctgcggatgggctgccgctgcatcgagctggactgctgggacggg
cccgacggcaagcccatcatctaccacggctggacgcggaccaccaagatcaagttcgac
gacgttgtgcaggccatcaaagaccacgcctttgtcacctccagcttccccgtgatcctg
tccatcgaggagcactgctgtgtggagcagcagcgccacatggccagggtgttcaaggaa
gtgtttggagacctgctgctgaccaaacccaaggaggccagtgccgaccagctgccgtcg
cccagccagctgcgcgggaagatcatcatcaagcataagaagctgggcccccgcggtgac
gtggatgtcaacatggaggacaagaaggacgagcacaagcagcagggcgaactgcacatg
tgggaccccatcgaccagaaatggactcggcactactgtgccgttgctgatgccaagctg
tccttcagcgatgacattgaacagactgtggaagaggagctgcccctggatataccccca
acagagctgcattttggggagaagtggttccacaagaaggtggagaagaggacaagtgcc
gagaagctgctgcaggaatactgtgccgagacagggggcaaggatgggaccttcttggtg
cgggagagtgagaccttccccaacgactacaccttgtccttctggcggtcgggccgcgtg
cagcactgccggatccgctccaccatggagggcgggaccatgaagtactacctgaccgac
aacctcatgttcaccagcatctacgctctcatccagcactaccgcgagacacacctgcgc
tgcgccgagttcgagctccggctgaccgaccccgtgcccaaccccaacccgcacgagtcc
aagccgtggtactacgatgggctgagccgtggagaagcggaggacatgctgatgcggatc
ccccgggatggggccttcctgatccggaagcgggaaggtaccgactcctatgccatcacc
ttcagggccaggggcaaggtgaagcactgtcgcatcaaccgagacggccggcacttcgtg
ctgggcacctccgcctacttcgagagccttgtggagctggtcagctactacgagaagcac
gcactctaccggaagatgaaactgcgctaccccgtgacccccgagctcctggagcgctac
aacacggaaagagatataaactccctctacgatgtcagcaggatgtatgtggatcccagt
gaaatcaatccttcaatgcctcagagaaccgtgaaagctctgtatgactacagggccaag
cagagtgacgagctgagcttttgccgcggtgccctcatccacaacgtctccaaggagcct
gggggctggtggaaaggagactatgggaccagaatccagcagtacttcccgtccaattac
gtcgaggacatttcaccaacagaaggggaggaggtggataagcagattattgaagacaat
cccttagggtccctttgcagaggaatcctgaatctcaacatctataatgttgtaaaagcc
ccacatgggaagaaccagaagcctttcgtctttatcttggagcccaagaagcagggcgac
cctccggtagagtttgccacggacagcgtggaggagctgtttgagtggttccagagcatc
cgggagatcacctggaagatggacgccaaggagaacaacatgaagtactgggagaagaac
cagtccatcgccatcgagctctcggacctggtcgtctactgcaagccaaccagcaagacc
aaggacaacctcgaaaaccctgacttccgagaaatccgctccttcgtggagacgaaggct
gacagtatcgtcagacagaagcccagcgatctcctgaaatacaatcaaaagggcctgacc
cgtgtgtaccccaaaggacagcgggtggactcgtccaactatgaccccttccgcctctgg
ctgtgcggctcccagatggtggcactcaatttccagactccagataagtacatgcagatg
aaccacgccctgttctccctcaacgggcggacgggctacgtcctgcagcctgagagcatg
agggcggagaagtacgaccccatgccacccgagtcccagaggaagatccagatgaccctg
acggtcaaggtgctgggggcccgtcacctccccaagcccggccgcagcatcgcgtgcccc
ttcgtggaggtggagatatgcggagcggagtacgacagcaacaagtttaagacgacggtt
gtgaatgacaatggcctcagccctgtttggaccccaacgcaggagaaggtgacgtttgag
atttatgaccccaaccttgcgtttctgcgctttgtggtttatgaggaagatatgttcagc
gatcccaactttctggcccatgccacgtaccccattaaaggaatcaagtcaggatttaga
tctgttcctctgaagaacggctacagtgaagacattgagctggcgtccctcctggttttc
tgtgagatgcggccagtcctggagagcgaagaggagctgtattcctcctgccgccagctg
cggaggcggcaagaagaactgaacaaccagctctttctgtacgacacccaccagaacctg
cgcagtgccacccgcgatgccctggtcagagaattcaacgtcaacgagaaccagctgcag
ctgtaccaggagaagtgcaaccgcaggttaagagagaagagagtcagcaacagcaagttt
tactcatag

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