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KEGG   Bison bison bison (American bison): 104997112
Entry
104997112         CDS       T08726                                 
Symbol
CACNA1D
Name
(RefSeq) voltage-dependent L-type calcium channel subunit alpha-1D isoform X1
  KO
K04851  voltage-dependent calcium channel L type alpha-1D
Organism
bbis  Bison bison bison (American bison)
Pathway
bbis04010  MAPK signaling pathway
bbis04020  Calcium signaling pathway
bbis04022  cGMP-PKG signaling pathway
bbis04024  cAMP signaling pathway
bbis04218  Cellular senescence
bbis04260  Cardiac muscle contraction
bbis04261  Adrenergic signaling in cardiomyocytes
bbis04270  Vascular smooth muscle contraction
bbis04530  Tight junction
bbis04713  Circadian entrainment
bbis04723  Retrograde endocannabinoid signaling
bbis04724  Glutamatergic synapse
bbis04725  Cholinergic synapse
bbis04726  Serotonergic synapse
bbis04727  GABAergic synapse
bbis04728  Dopaminergic synapse
bbis04911  Insulin secretion
bbis04912  GnRH signaling pathway
bbis04921  Oxytocin signaling pathway
bbis04924  Renin secretion
bbis04925  Aldosterone synthesis and secretion
bbis04927  Cortisol synthesis and secretion
bbis04929  GnRH secretion
bbis04930  Type II diabetes mellitus
bbis04934  Cushing syndrome
bbis04935  Growth hormone synthesis, secretion and action
bbis04973  Carbohydrate digestion and absorption
bbis05010  Alzheimer disease
bbis05020  Prion disease
bbis05022  Pathways of neurodegeneration - multiple diseases
bbis05031  Amphetamine addiction
bbis05207  Chemical carcinogenesis - receptor activation
bbis05410  Hypertrophic cardiomyopathy
bbis05412  Arrhythmogenic right ventricular cardiomyopathy
bbis05414  Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:bbis00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    104997112 (CACNA1D)
   04022 cGMP-PKG signaling pathway
    104997112 (CACNA1D)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    104997112 (CACNA1D)
   04929 GnRH secretion
    104997112 (CACNA1D)
   04921 Oxytocin signaling pathway
    104997112 (CACNA1D)
   04935 Growth hormone synthesis, secretion and action
    104997112 (CACNA1D)
   04924 Renin secretion
    104997112 (CACNA1D)
   04925 Aldosterone synthesis and secretion
    104997112 (CACNA1D)
   04927 Cortisol synthesis and secretion
    104997112 (CACNA1D)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    104997112 (CACNA1D)
  09156 Nervous system
   04724 Glutamatergic synapse
    104997112 (CACNA1D)
   04727 GABAergic synapse
    104997112 (CACNA1D)
   04725 Cholinergic synapse
    104997112 (CACNA1D)
   04728 Dopaminergic synapse
    104997112 (CACNA1D)
   04726 Serotonergic synapse
    104997112 (CACNA1D)
   04723 Retrograde endocannabinoid signaling
    104997112 (CACNA1D)
  09159 Environmental adaptation
   04713 Circadian entrainment
    104997112 (CACNA1D)
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    104997112 (CACNA1D)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    104997112 (CACNA1D)
   05020 Prion disease
    104997112 (CACNA1D)
   05022 Pathways of neurodegeneration - multiple diseases
    104997112 (CACNA1D)
  09165 Substance dependence
   05031 Amphetamine addiction
    104997112 (CACNA1D)
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    104997112 (CACNA1D)
   05412 Arrhythmogenic right ventricular cardiomyopathy
    104997112 (CACNA1D)
   05414 Dilated cardiomyopathy
    104997112 (CACNA1D)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    104997112 (CACNA1D)
   04934 Cushing syndrome
    104997112 (CACNA1D)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:bbis04040]
    104997112 (CACNA1D)
Ion channels [BR:bbis04040]
 Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   104997112 (CACNA1D)
SSDB
Motif
Pfam: Ion_trans CAC1F_C Ca_chan_IQ GPHH PKD_channel
Other DBs
NCBI-GeneID: 104997112
NCBI-ProteinID: XP_010849980
Ensembl: ENSBBBG00000004432
UniProt: A0A6P3IGG9
Position
Unknown
AA seq 2139 aa
MMMMMMMKKMQHQRQQQADHANEANYARGTRLPLSGEGPTSQPNSSKQTVLSWQAAIDAA
RQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACI
SIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKI
IAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALR
AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKT
CFFADSDMVAEEDPAPCAFSGNGRQCTANGTECRSGWGGPQGGXTNFDNFAFAMLTVFQC
ITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARG
DFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEESKRNTSMPTSETESVNTENVS
GEGENRGCCGSLCQAISKSKLSRRWRRWNRFSRRRCRAAVKSVTFYWLVIVLVFLNTLTI
SSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGIT
ETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLF
IIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGG
PSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARK
ESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPPCDVPVGEEEEEEEEDEPEVP
AGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSS
AALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMMTFGAFLHKGAFCRNYFNLLDM
LVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMI
VTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNS
DFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENVGPIYNYRVEISIFFIIYIIIVA
FFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWY
VVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFK
PKGYFSDAWNTFDSLIVIGSIVDVALSEADNSEESNRISITFFRLFRVMRLVKLLSRGEG
IRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQA
VLLLFRCATGEAWQEIMLACLPGKQCDPDSDYNPGEEYTCGSNFAIVYFISFYMLCAFLI
INLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPP
LGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLEQANEELRA
VIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKN
STIALQAGLRTLHDIGPEIRRAISCDLQDDDPEETKREDEEDVFKRNGALLGNHVNHVNS
DRRDSLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPSSTN
ANLNNANMCKAAPGKRPSIGNLELVSENGHHSFHKHGREPHRRCSIKRSDSGDEQFPTIC
REDPEIHGYFRDPHCPGEQEYFSSEEYYEDDSSPTGSRQSYGCGYYNWYLGSSLDFERPR
GYHHPQSFSEDDDSPVGYDSRRSPRRRLLPPTPTSPRRSSFNFECLRRQSSQEEVPPSPA
FPPRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRSWATPPATPSYRDWTPCYTPLIQ
VERPEAPDQVNGSLPSLHRSSWYTDEPSVSYRTFTPASLTVPSSFHNKNSDKQRSADSLV
EAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEMESAASNLLNGNVHPRANGDVGPV
SHRQDYELQDFGPGYSDEEPDPGRDEEDLADEMICITTL
NT seq 6420 nt   +upstreamnt  +downstreamnt
atgatgatgatgatgatgatgaaaaaaatgcagcatcaacggcagcagcaagcggaccac
gcgaacgaggcaaactatgcaagaggcaccaggctccctctttctggtgaaggaccaact
tctcagccgaatagctccaagcaaaccgtcctgtcttggcaagctgcaatcgacgctgct
agacaggccaaggctgcccaaactatgagcacctccgcacccccacctgtcggatctctc
tcccaaagaaaacgtcagcaatacgccaagagcaaaaaacagggtaactcgtccaacagc
cgacctgcccgtgcccttttctgtttgtctctcaataaccccatccgaagagcctgcatt
agtatagtggaatggaaaccatttgacatatttatattattggctatttttgccaattgt
gtggccttagctatttacatcccattccctgaagatgattctaattcaacaaatcataac
ttggaaaaagtagaatatgccttcctgattatttttacagtcgaaacatttttgaagatt
atagcatatggattattgctacatcctaatgcttatgttaggaatggatggaatttactg
gattttgttatagtcatagtaggattgtttagtgtaattttggaacaattaaccaaagaa
acagaaggcggtaaccactccagtggcaaatcaggaggctttgacgtcaaagccctccgc
gcctttcgagtgttacgaccacttcgactagtatcaggagtgcccagtttacaagttgtc
ctgaactccattataaaagccatggttcccctccttcacatagcccttttggtattattt
gtaatcataatctatgctattataggattggagctttttattggaaaaatgcacaaaaca
tgtttttttgctgactcagatatggtggctgaagaggacccagcgccgtgtgcgttctca
gggaacggacgccagtgcaccgccaatggcacggagtgtaggagtggctggggggggccc
caggggggnnnnaccaactttgacaactttgcctttgccatgctcaccgtgtttcagtgc
atcaccatggagggctggacagacgtgctctactggatgaatgatgctatgggatttgaa
ttgccctgggtgtattttgtcagtctcgtcatctttgggtcatttttcgtactaaatctt
gtacttggtgtattgagcggagagttctcgaaggaaagggagaaagcaaaagcacgggga
gacttccagaagctccgggagaagcagcagctggaagaggatcttaagggctacttggac
tggatcacccaagcagaagacattgatcctgagaatgaagaagaaggaggcgaggagagc
aaacgaaataccagcatgcccaccagtgagacggagtctgtgaacacagagaacgtgagc
ggggaaggcgagaaccgaggctgctgtgggagtctctgtcaagccatctcaaagtccaag
ctcagccgccgctggcgccgctggaaccgcttcagtcgcagaaggtgtagggctgctgtg
aagtccgtcacgttttactggctggtcattgtcctggtgtttctcaacaccttaaccatt
tcctccgagcactacaaccagcctgactggttgacacagattcaagatattgctaacaaa
gtcctcttggctctgttcacctgtgagatgctggtcaaaatgtacagcttgggtctccag
gcgtactttgtctctcttttcaatcggtttgattgcttcgtggtgtgcggcggaattacc
gagacgatcctggtggaactggaaatcatgtctcccctgggcatctctgtgttccgctgt
gtgcggctcttgagaattttcaaagtgaccaggcactggacctccctgagcaacttggtg
gcatccttgttaaactccatgaagtccatcgcttcgctgctgcttctgctttttctcttc
atcatcatcttctccttgctggggatgcagctgtttggcggcaagtttaattttgatgaa
acgcaaaccaagcggagcaccttcgataatttcccgcaagcccttctcacagtgttccag
atcctgacaggcgaagattggaatgctgtgatgtatgacggtatcatggcatatgggggc
ccatcatcttctggaatgatcgtctgcatctacttcatcatcctcttcatttgcggtaac
tatattctactgaatgtcttcttggccatcgctgtagacaatttggctgatgctgaaagt
ttgaatactgctcagaaggaggaagctgaagaaaaggaaaggaaaaagattgccagaaaa
gaaagtctggaaaataaaaagaacaacaaaccagaagtcaaccagatagccaacagtgac
aacaaggttaccatcgacgactacagagaagaggatgaggacaaggacccctacccaccc
tgtgatgtgccagtaggtgaagaggaagaggaggaggaagaggatgaacctgaggttcct
gctggcccccgtcctcgcagaatctctgagttgaacatgaaagagaaaatcgcccccatc
ccggaagggagtgctttcttcattctcagcaagaccaacccgatccgcgtgggctgccac
aagctcatcaaccaccacatcttcaccaacctcatcctcgtcttcatcatgctgagcagc
gccgccctcgccgctgaggaccccatccgcagccactccttccggaacactatactgggt
tactttgactatgctttcacagccatctttactgttgaaatcctgttgaagatgatgacc
tttggcgctttcctccacaaaggcgctttctgcaggaactacttcaacttactggatatg
ctggttgttggggtgtctttggtgtcatttgggatccaatccagtgccatctctgttgtg
aagattctgagggtcctaagggtcctgaggcctctcagggccatcaacagagcgaaagga
cttaagcatgtggtccagtgtgtcttcgtggccatccggacgattggcaacatcatgatc
gtcaccacgctcctccagttcatgttcgcctgcatcggggtccagctcttcaagggaaag
ttctatcgctgcacagacgaagccaaaagtaaccccgaagagtgcagggggctcttcatc
ctctacaaggatggggatgttgatagtcctgtggtccgtgagaggatctggcaaaacagt
gatttcaactttgacaacgtcctctcggctatgatggctctgttcacagtctccacgttc
gagggctggcccgcgttgctgtacaaagccatcgattcgaacggagagaatgtgggcccc
atctacaactaccgtgtggagatctccatcttcttcatcatctacatcatcattgtcgca
ttcttcatgatgaacatcttcgtgggcttcgtcatcgtcacatttcaggagcagggagag
aaagagtataagaactgtgagctggacaaaaatcagcgtcagtgtgttgaatacgccttg
aaggcacgtccgctgcggagatacatccccaaaaacccctaccagtacaagttctggtac
gtggtgaactcctcgcctttcgaatacatgatgtttgtcctcatcatgctcaacacactc
tgcttggccatgcagcactacgagcagtccaagatgtttaatgacgccatggacatcctg
aacatggtcttcactggggtgttcactgtcgagatggttttgaaagtcattgcatttaag
cctaaggggtactttagtgacgcctggaacacctttgactccctcatcgtaatcggcagc
attgtagacgtggccctcagcgaagccgacaactctgaagagagcaatagaatctccatc
acctttttccgtcttttccgagtgatgcgattggtgaagcttctcagcaggggggaaggc
atccggacgctgctgtggacttttattaagtccttccaggcgctcccgtatgtcgccctt
ctcattgccatgctgttcttcatctacgcggtcatcggcatgcagatgttcgggaaagtg
gccatgagagataacaaccagatcaacagaaacaacaatttccagacctttccccaggcg
gtgctgctgctcttcaggtgtgcgacgggggaggcctggcaggaaatcatgttagcctgc
ctcccggggaagcaatgcgaccccgactcggattacaaccctggggaggaatacacatgt
gggagcaacttcgccatcgtttatttcatcagtttttatatgctctgcgcatttctgatc
atcaacctcttcgtggctgtcatcatggacaattttgattatctcacccgggactggtct
attctggggcctcaccatttagatgaattcaaacggatctggtctgaatatgaccctgag
gcaaagggcaggatcaagcacctggacgtggtcactctgctccgccgcatccagcctccc
ctgggcttcgggaagttgtgtccacaccgggtagcctgcaagagactagttgctatgaac
atgccactcaacagtgatgggacagtcatgtttaatgcaactctgtttgctctggttcga
acggctcttaaaatcaagactgaaggcaacctggaacaagctaatgaagaactccgagct
gtgatcaagaaaatttggaagaaaaccagcatgaagctacttgaccaagttgttcctcca
gctggtgatgatgaggtaaccgtggggaagttctatgccactttcctgatacaggactac
tttaggaaattcaagaaacggaaagaacaaggactggtgggaaaataccccgcgaagaac
agcacaattgccctacaggcgggattaaggacactgcatgacattgggccagaaatccgg
cgtgctatatcatgcgatttgcaagatgatgatccagaggaaacaaaacgagaagatgaa
gaagatgtgttcaaaagaaatggtgccctgcttggaaaccatgtcaatcatgttaatagt
gataggagagattcccttcagcagaccaataccacccaccgtcccctgcatgtccaaagg
ccttcaattccacctgcaagtgatactgagaaaccgctgtttcctccagcaggaaattcg
gtgtgtcataaccatcataaccataattccataggaaagcaagttcccagctcaacaaat
gccaatctcaataatgccaatatgtgcaaagctgcccctggaaagcggcccagcattggg
aaccttgagcttgtgtctgaaaacgggcatcattccttccacaagcatggccgtgagcct
cacagaaggtgcagtattaaaaggtctgactcaggagacgagcagttcccgacgatttgc
cgggaggacccggagatacacggctacttcagggacccccactgcccaggggagcaggag
tatttcagcagcgaggagtactatgaggatgacagctcgcccaccgggagcaggcaaagc
tacggctgcggctactataactggtacctgggcagcagcttggactttgagcggcctcga
ggctaccatcacccccaaagcttctcagaggacgacgactcgcccgttggctacgattcc
cggaggtctccgaggcgacgcctactacctcccacccctacatccccccgcaggtcttcc
ttcaacttcgagtgcctgcgccggcagagcagccaggaggaggtcccgccgtcgcccgcc
ttcccgccccgcacggccctgcccctgcacctgatgcagcagcagatcatggcagtcgcc
ggcctagattccagtaaagcccagaagtactcgccaagccactccacccggtcgtgggcc
acgcccccggccacgccgtcgtatcgggactggacaccgtgttataccccgctgatccag
gttgagcggccagaggccccagaccaggtcaacggcagcctcccgtccctgcaccgcagc
tcgtggtacacggacgagcccagcgtctcctatcggacgttcacaccagccagcctgacc
gtccccagcagcttccacaacaagaacagcgacaagcagaggagcgcggacagcctggtg
gaggcagttctgatatccgaaggcttaggacggtacgcgagggacccaaagttcgtgtcg
gcgacaaaacacgaaatcgccgatgcctgtgacttaaccatcgacgagatggagagtgcg
gccagcaacctgctaaacgggaacgtgcatccccgggccaatggagacgtgggccccgtt
tcccaccggcaagactacgagctccaggactttgggcctggctacagcgacgaggagccg
gaccccgggagggacgaggaggacctggcagacgagatgatttgcatcaccaccctgtag

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (35)   
   KEGG PATHWAY (35)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
Protein sequence (3)   
   UniProt (1)   
   RefSeq(pep) (2)   
DNA sequence (2)   
   RefSeq(nuc) (2)   
Protein domain (5)   
   Pfam (5)   
All databases (52)   

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