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KEGG   Bison bison bison (American bison): 104996518
Entry
104996518         CDS       T08726                                 
Symbol
PLCG2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1
  KO
K05859  phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
Organism
bbis  Bison bison bison (American bison)
Pathway
bbis00562  Inositol phosphate metabolism
bbis01100  Metabolic pathways
bbis01521  EGFR tyrosine kinase inhibitor resistance
bbis04012  ErbB signaling pathway
bbis04014  Ras signaling pathway
bbis04020  Calcium signaling pathway
bbis04062  Chemokine signaling pathway
bbis04064  NF-kappa B signaling pathway
bbis04066  HIF-1 signaling pathway
bbis04070  Phosphatidylinositol signaling system
bbis04072  Phospholipase D signaling pathway
bbis04360  Axon guidance
bbis04370  VEGF signaling pathway
bbis04380  Osteoclast differentiation
bbis04611  Platelet activation
bbis04613  Neutrophil extracellular trap formation
bbis04625  C-type lectin receptor signaling pathway
bbis04650  Natural killer cell mediated cytotoxicity
bbis04662  B cell receptor signaling pathway
bbis04664  Fc epsilon RI signaling pathway
bbis04666  Fc gamma R-mediated phagocytosis
bbis04670  Leukocyte transendothelial migration
bbis04722  Neurotrophin signaling pathway
bbis04750  Inflammatory mediator regulation of TRP channels
bbis04919  Thyroid hormone signaling pathway
bbis04933  AGE-RAGE signaling pathway in diabetic complications
bbis04935  Growth hormone synthesis, secretion and action
bbis05167  Kaposi sarcoma-associated herpesvirus infection
bbis05169  Epstein-Barr virus infection
bbis05170  Human immunodeficiency virus 1 infection
bbis05171  Coronavirus disease - COVID-19
bbis05200  Pathways in cancer
bbis05205  Proteoglycans in cancer
bbis05206  MicroRNAs in cancer
bbis05214  Glioma
bbis05223  Non-small cell lung cancer
bbis05225  Hepatocellular carcinoma
Module
bbis_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:bbis00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    104996518 (PLCG2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    104996518 (PLCG2)
   04064 NF-kappa B signaling pathway
    104996518 (PLCG2)
   04066 HIF-1 signaling pathway
    104996518 (PLCG2)
   04070 Phosphatidylinositol signaling system
    104996518 (PLCG2)
   04072 Phospholipase D signaling pathway
    104996518 (PLCG2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    104996518 (PLCG2)
   04613 Neutrophil extracellular trap formation
    104996518 (PLCG2)
   04650 Natural killer cell mediated cytotoxicity
    104996518 (PLCG2)
   04662 B cell receptor signaling pathway
    104996518 (PLCG2)
   04664 Fc epsilon RI signaling pathway
    104996518 (PLCG2)
   04666 Fc gamma R-mediated phagocytosis
    104996518 (PLCG2)
   04670 Leukocyte transendothelial migration
    104996518 (PLCG2)
   04062 Chemokine signaling pathway
    104996518 (PLCG2)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    104996518 (PLCG2)
   04919 Thyroid hormone signaling pathway
    104996518 (PLCG2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    104996518 (PLCG2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    104996518 (PLCG2)
  09158 Development and regeneration
   04360 Axon guidance
    104996518 (PLCG2)
   04380 Osteoclast differentiation
    104996518 (PLCG2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    104996518 (PLCG2)
   05206 MicroRNAs in cancer
    104996518 (PLCG2)
   05205 Proteoglycans in cancer
    104996518 (PLCG2)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    104996518 (PLCG2)
   05214 Glioma
    104996518 (PLCG2)
   05223 Non-small cell lung cancer
    104996518 (PLCG2)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    104996518 (PLCG2)
   05171 Coronavirus disease - COVID-19
    104996518 (PLCG2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    104996518 (PLCG2)
   05169 Epstein-Barr virus infection
    104996518 (PLCG2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    104996518 (PLCG2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    104996518 (PLCG2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:bbis04131]
    104996518 (PLCG2)
Enzymes [BR:bbis01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     104996518 (PLCG2)
Membrane trafficking [BR:bbis04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    104996518 (PLCG2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    104996518 (PLCG2)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 C2 SH3_1 SH3_9 PH PH_12 EF-hand_PLCG1 SH2_1 SH3_2 PH_14 GDPD EF-hand_like
Other DBs
NCBI-GeneID: 104996518
NCBI-ProteinID: XP_010849103
Ensembl: ENSBBBG00000004928
UniProt: A0A6P3I3N7
Position
Unknown
AA seq 1266 aa
MASTMANVDNLPEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQGAWSKTAD
KIEGFLDIMEIKEIRPGKSSKDFERAKAVRQKEECCFTVLYGSQFILSTLSLAADSKEDA
AKWLSGLKILHQEVMSASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLVNFKVSS
AKFLKDKFLEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFLLGNTDRPDAS
AVHLHDFQRFLLHEQQELWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSREN
SIWDEKYDVVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSTEAYIRCLRMGCRCIELD
CWDGPDGKPIIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCCVEQQRHMAR
VFKEVFGDLLLTKPKEASADQLPSPSQLRGKIIIKHKKLGPRGDVDVNMEDKKDEHKQQG
ELHMWDPIDQKWTRHYCAVADAKLSFSDDIEQTVEEELPLDIPPTELHFGEKWFHKKVEK
RTSAEKLLQEYCAETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTMKY
YLTDNLMFTSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDGLSRGEAEDM
LMRIPRDGAFLIRKREGTDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSY
YEKHALYRKMKLRYPVTPELLERYNTERDINSLYDVSRMYVDPSEINPSMPQRTVKALYD
YRAKQSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISPTEGEEVDKQI
IEDNPLGSLCRGILNLNIYNVVKAPHGKNQKPFVFILEPKKQGDPPVEFATDSVEELFEW
FQSIREITWKMDAKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFV
ETKADSIVRQKPSDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTPDK
YMQMNHALFSLNGRTGYVLQPESMRAEKYDPMPPESQRKIQMTLTVKVLGARHLPKPGRS
IACPFVEVEICGAEYDSNKFKTTVVNDNGLSPVWTPTQEKVTFEIYDPNLAFLRFVVYEE
DMFSDPNFLAHATYPIKGIKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSS
CRQLRRRQEELNNQLFLYDTHQNLRSATRDALVREFNVNENQLQLYQEKCNRRLREKRVS
NSKFYS
NT seq 3801 nt   +upstreamnt  +downstreamnt
atggcgagcaccatggccaacgtggacaacctcccggagtacgagaagagtcagatcaag
cgggccctggagctgggcaccgtcatgaccgtgttcagcttccgcaagtccaccccggag
cggaggaccgtccaggtgatcatggagacgcggcagggggcctggagcaagacggccgac
aagatcgagggcttcctggacatcatggagataaaggagatccggccggggaagagctcc
aaggatttcgagcgcgcgaaagcggtccgccagaaggaagaatgctgcttcaccgttctg
tacggctcccagtttatcctcagcacgctcagcctggcagctgactcgaaggaggatgcc
gctaagtggctgtctggcctgaagatcttacaccaggaagtgatgagcgcgtccaccccc
accatcatcgagagctggctgagaaagcagatttattctgtggatcaaaccaggagaaac
agcatcagcctccgggagttgaagaccatcttgcctctggtcaacttcaaagtgagcagt
gccaagttcctcaaagataagttcctggaaataggcgcacacaaagatgaactcagcttt
gaacagttccatctcttctataaaaaacttatgtttgaacagcaaaaatcgatccttgat
gaattcaaaaaggattcttccgtgttcctcttgggcaacaccgaccggccggacgcctct
gctgtccacctgcacgacttccagcggtttctcttgcatgaacagcaggagctttgggct
caggatctgaacaaagtccgtgagcggatgacgaagtttattgacgacaccatgagggaa
actgctgaacccttcctgtttgtggatgagttcctcacgtacctgttttcccgggagaac
agcatctgggacgagaagtacgacgtggtggacatgcaggacatgaacaaccccttgtct
cattactggatctcctcgtcgcacaacacgtacctcacgggggaccagctgcggagcgag
tcgtccacggaggcctacatccgctgcctgcggatgggctgccgctgcatcgagctggac
tgctgggacgggcccgatggcaagcccatcatctaccacggctggacgcggaccaccaag
atcaagttcgacgacgttgtgcaggccatcaaagaccacgcctttgtcacctccagcttc
cctgtgatcctgtccatcgaggagcactgctgtgtggagcagcagcgccacatggccagg
gtgttcaaggaagtgtttggagacctgctgctgaccaaacccaaggaggccagtgccgac
cagctgccgtcgcccagccagctgcgcgggaagatcatcatcaagcataagaagctgggc
ccccgcggtgacgtggacgtcaacatggaggacaagaaggacgagcacaagcagcagggc
gaactgcacatgtgggaccccatcgaccagaaatggactcggcactactgtgccgttgct
gatgccaagctgtccttcagcgatgacattgaacagactgtggaagaggagctgcccctg
gatatacccccaacagagctgcattttggggagaagtggttccacaagaaggtggagaag
aggacaagtgccgagaagctgctgcaggaatactgcgctgagacagggggcaaggatggg
accttcttggtgcgggagagtgagaccttccccaacgactacaccttgtccttctggcgg
tcgggccgcgtgcagcactgccggatccgctccaccatggagggtgggaccatgaagtac
tacctgaccgacaacctcatgttcaccagcatctacgctctcatccagcactaccgcgag
acacacctgcgctgcgccgagttcgagctccggctgaccgaccccgtgcccaaccccaac
ccgcacgagtccaagccgtggtactacgatggcctgagccgtggagaagcggaggacatg
ctgatgcggatcccccgggacggggccttcctgatccggaagcgggaaggtaccgactcc
tatgccatcaccttcagggccaggggcaaggtgaagcactgtcgcatcaaccgagacggc
cggcacttcgtgctgggcacctccgcctacttcgagagcctcgtggagctggtcagctac
tacgagaagcacgcgctctaccggaagatgaaactgcgctaccccgtgacccccgagctc
ctggagcgctacaacacggaaagagatataaactccctctacgatgtcagcaggatgtat
gtggatcccagtgaaatcaatccttcaatgcctcagagaaccgtgaaagctctgtatgac
tacagggccaagcagagtgacgagctgagcttttgccgcggtgccctcatccacaacgtc
tccaaggagcctgggggctggtggaaaggagactatgggaccagaatccagcagtacttc
ccgtccaattacgtcgaggacatttcaccaacagaaggggaggaggtggataagcagatt
attgaagacaatcccttagggtccctttgcagaggaatcctgaatctcaacatctataat
gttgtaaaagccccacatgggaagaaccagaagcctttcgtctttatcttggagcccaag
aagcagggcgaccctccggtagagtttgccacggacagcgtggaggagctgtttgagtgg
ttccagagcatccgggagatcacctggaagatggacgccaaggagaacaacatgaagtac
tgggagaagaaccagtccatcgccatcgagctctcggacctggtcgtctactgcaagcca
accagcaagaccaaggacaacctcgaaaaccctgacttccgagaaatccgctccttcgtg
gagacgaaggctgacagtatcgtcagacagaagcccagcgatctcctgaaatacaatcaa
aagggcctgacccgtgtgtaccccaaaggacagcgggtggactcgtccaactatgacccc
ttccgcctctggctgtgcggctcccagatggtggcactcaatttccagactccagataag
tacatgcagatgaaccacgccctgttctccctcaacgggcggacgggctacgtcctgcag
cctgagagcatgagggcggagaagtacgaccccatgccacccgagtcccagaggaagatc
cagatgaccctgacggtcaaggtgctgggggcccgtcacctccccaagcccggccgcagc
atcgcgtgccccttcgtggaggtggagatatgcggagcggagtacgacagcaacaagttt
aagacgacggttgtgaatgacaatggcctcagccctgtttggaccccaacgcaggagaag
gtgacgtttgagatttatgaccccaaccttgcgtttctgcgcttcgtggtttatgaggaa
gatatgttcagcgatcccaactttctggcccatgccacgtaccccattaaaggaatcaag
tcaggatttagatctgttcctctgaagaacggctacagtgaagacattgagctggcatcc
ctcctggttttctgtgagatgcggccagtcctggagagcgaagaggagctgtattcctcc
tgccgccagctgcggaggcggcaagaagaactgaacaaccagctctttctgtacgacacc
caccagaacctgcgcagcgccacccgcgatgccctggtcagagaattcaacgtcaacgag
aaccagctgcagctgtaccaggagaagtgcaaccgcaggttaagagagaagagagtcagc
aacagcaagttttactcatag

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (38)   
   KEGG PATHWAY (37)   
   KEGG MODULE (1)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
Protein sequence (3)   
   UniProt (1)   
   RefSeq(pep) (2)   
DNA sequence (2)   
   RefSeq(nuc) (2)   
Protein domain (15)   
   Pfam (15)   
All databases (78)   

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