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KEGG   Orcinus orca (killer whale): 101276749
Entry
101276749         CDS       T05247                                 
Symbol
CACNA1D
Name
(RefSeq) voltage-dependent L-type calcium channel subunit alpha-1D isoform X1
  KO
K04851  voltage-dependent calcium channel L type alpha-1D
Organism
oor  Orcinus orca (killer whale)
Pathway
oor04010  MAPK signaling pathway
oor04020  Calcium signaling pathway
oor04022  cGMP-PKG signaling pathway
oor04024  cAMP signaling pathway
oor04218  Cellular senescence
oor04260  Cardiac muscle contraction
oor04261  Adrenergic signaling in cardiomyocytes
oor04270  Vascular smooth muscle contraction
oor04530  Tight junction
oor04713  Circadian entrainment
oor04723  Retrograde endocannabinoid signaling
oor04724  Glutamatergic synapse
oor04725  Cholinergic synapse
oor04726  Serotonergic synapse
oor04727  GABAergic synapse
oor04728  Dopaminergic synapse
oor04911  Insulin secretion
oor04912  GnRH signaling pathway
oor04921  Oxytocin signaling pathway
oor04924  Renin secretion
oor04925  Aldosterone synthesis and secretion
oor04927  Cortisol synthesis and secretion
oor04929  GnRH secretion
oor04930  Type II diabetes mellitus
oor04934  Cushing syndrome
oor04935  Growth hormone synthesis, secretion and action
oor04973  Carbohydrate digestion and absorption
oor05010  Alzheimer disease
oor05020  Prion disease
oor05022  Pathways of neurodegeneration - multiple diseases
oor05031  Amphetamine addiction
oor05207  Chemical carcinogenesis - receptor activation
oor05410  Hypertrophic cardiomyopathy
oor05412  Arrhythmogenic right ventricular cardiomyopathy
oor05414  Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:oor00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    101276749 (CACNA1D)
   04022 cGMP-PKG signaling pathway
    101276749 (CACNA1D)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    101276749 (CACNA1D)
   04929 GnRH secretion
    101276749 (CACNA1D)
   04921 Oxytocin signaling pathway
    101276749 (CACNA1D)
   04935 Growth hormone synthesis, secretion and action
    101276749 (CACNA1D)
   04924 Renin secretion
    101276749 (CACNA1D)
   04925 Aldosterone synthesis and secretion
    101276749 (CACNA1D)
   04927 Cortisol synthesis and secretion
    101276749 (CACNA1D)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    101276749 (CACNA1D)
  09156 Nervous system
   04724 Glutamatergic synapse
    101276749 (CACNA1D)
   04727 GABAergic synapse
    101276749 (CACNA1D)
   04725 Cholinergic synapse
    101276749 (CACNA1D)
   04728 Dopaminergic synapse
    101276749 (CACNA1D)
   04726 Serotonergic synapse
    101276749 (CACNA1D)
   04723 Retrograde endocannabinoid signaling
    101276749 (CACNA1D)
  09159 Environmental adaptation
   04713 Circadian entrainment
    101276749 (CACNA1D)
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    101276749 (CACNA1D)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101276749 (CACNA1D)
   05020 Prion disease
    101276749 (CACNA1D)
   05022 Pathways of neurodegeneration - multiple diseases
    101276749 (CACNA1D)
  09165 Substance dependence
   05031 Amphetamine addiction
    101276749 (CACNA1D)
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    101276749 (CACNA1D)
   05412 Arrhythmogenic right ventricular cardiomyopathy
    101276749 (CACNA1D)
   05414 Dilated cardiomyopathy
    101276749 (CACNA1D)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    101276749 (CACNA1D)
   04934 Cushing syndrome
    101276749 (CACNA1D)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:oor04040]
    101276749 (CACNA1D)
Ion channels [BR:oor04040]
 Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   101276749 (CACNA1D)
SSDB
Motif
Pfam: Ion_trans CAC1F_C Ca_chan_IQ GPHH PKD_channel
Other DBs
NCBI-GeneID: 101276749
NCBI-ProteinID: XP_004267968
Position
10:complement(34969491..35288252)
AA seq 2183 aa
MMMMMMMKKMQHQRQQQADHANEANYARGTRLPLSGEGPTSQPNSSKQTVLSWQAAIDAA
RQAKAAQTMSTSAPAPVGSLSQRKRQQYAKSKKQGNSSSSRPARALFCLSLNNPIRRACI
SIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKI
IAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALR
AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKT
CFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGISNFDNFAFAMLTVFQC
ITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSGEFSKEREKAKARG
DFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEESKRNTSMPTSETESVNTENVS
GEGENQGCCGSLWCWWRRRGTTKAGPSGCRRWGQAISKSKLSRRWRRWNRFSRRRCRAAV
KSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQ
AYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLV
ASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQ
ILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAES
LNTAQKEEAEEKERKKIARKESLENKKNNKPEINQIANSDNKVTIDDYREEDEDKDPYPP
CDVPVGEEEEEEEEDEPEVPAGPRPRRMSELNMKEKITPIPEGSAFFILSKTNPIRVGCH
KLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTT
FGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKG
LKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFI
LYKDGDVDNPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENVGP
IYNYRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYAL
KARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDIL
NMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIVDVALSEADPTESENVPVP
TATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAML
FFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKL
CDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPH
HLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNS
DGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDE
VTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKSSTIALQAGLRTLHDIGPEIRRAISC
DLQDDEPEETKGEEEEDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPP
ASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPSSTNANLNNANMSKAAPGKRPSIGNLEHV
PENGHHSFHKHGREPQRRCSIKRTRYYETYIRADSGDEQFPTICREDPEIHGYFRDPCCL
GEQEYFSSEECYEDDSSPTGSRQSYSCGYYTRYPGSSLDFERPRGYHHPQSFSEDDDSPV
CYDSRRSPRRRLLPPTPTSPRRSSFNFECLRRHSSQEEFLPSPAFPHRTALPLHLMQQQI
MAVAGLDSSKAQKYSPSHSTRSWATPPATPSYRDWTPCYTPLIQVERSEAPDQVNGSLPS
LHRSSWYTDEPGVSYRTFTPASLTVPSSFHNKNSDKQRSADSLVEAVLISEGLGRYARDP
KFVSATKHEIADACDLTIDEMESAASNLLNGNVHPRANGDVGPVSRRQDYELQDFGPGYS
DEEPDPGRDEEDLADEMICITTL
NT seq 6552 nt   +upstreamnt  +downstreamnt
atgatgatgatgatgatgatgaaaaaaatgcagcatcaacggcagcagcaagcggaccac
gcgaacgaggcaaactatgcaagaggcaccaggctccctctttctggtgaaggaccaact
tctcagccgaatagctccaagcaaaccgtcctgtcttggcaagccgcgatcgacgctgct
agacaggccaaggctgcccaaactatgagcacctctgcacccgcacctgtaggatctctc
tcccaaagaaaacgtcagcaatacgccaagagcaaaaaacagggtaactcgtccagcagc
cgacctgcccgcgcccttttctgtttgtcactcaataaccccatccgaagagcctgcatt
agtatagtggaatggaaaccatttgacatatttatattattggctatttttgccaattgt
gtggccttagctatttacatcccattccctgaagatgattctaattcaacaaatcataac
ttggaaaaagtagaatatgccttcctgattatttttacagtcgaaacatttttgaagatt
atagcgtatggattattgctacatcctaatgcttatgtaagaaatggatggaatttactg
gattttgttatagtaatagtaggattgtttagtgtaattttggaacaattaaccaaagaa
acagaaggcggcaaccactccagtggcaaatcgggaggctttgatgtcaaagccctccgc
gcctttcgagtgttacgaccacttcgactagtatcaggagtgcccagtttacaagttgtc
ctgaactccatcataaaagccatggttcccctccttcacatagcccttttggtgttattt
gtaatcataatctatgctattataggattggaactttttattggaaaaatgcacaaaaca
tgtttttttgctgactcagatatcgtagctgaggaggacccagcaccgtgtgcgttctca
gggaatggacgccagtgtaccgccaatggcacagagtgcaggagtggctgggttggcccc
aatggcggcatcagcaactttgataactttgcctttgccatgctcaccgtgtttcagtgc
atcaccatggagggctggacagacgtgctctactgggtaaatgatgcgataggatgggaa
tggccatgggtgtattttgttagtctcatcatccttggctcatttttcgtccttaacctg
gttcttggtgtccttagtggagaattctcaaaggaaagggagaaggcgaaagcacgggga
gacttccagaagctgcgggagaagcagcagctggaagaggatctcaagggctacttggat
tggatcacccaagcagaagatattgatcccgagaacgaagaagaaggaggagaggaaagc
aaacgaaataccagcatgcccaccagtgagacggagtctgtgaacacggagaacgtgagt
ggggaaggcgagaaccaaggctgctgtgggagcctctggtgctggtggagaagaagaggc
accaccaaggccgggccctctgggtgtcggcggtggggtcaagccatctcaaagtccaag
ctcagccgacgctggcgccgctggaaccgcttcagtcgcagaaggtgtagggctgccgtg
aagtctgtcacgttttactggctggttattgtcctggtgtttctcaacaccttaaccatt
tcctctgagcactacaaccagcctgactggctgacacagattcaagatatcgctaacaaa
gtcctcttggctctgttcacctgtgagatgcttgtaaagatgtacagcttgggtctccag
gcatatttcgtctctcttttcaatcggtttgattgcttcgtggtgtgtggaggaattacg
gaaacgatcttggtggaactggaaatcatgtctcctctgggcatctctgtgtttcgctgt
gtgcggctcctgagaattttcaaagtgaccaggcactggacctccctgagcaacttggtg
gcatccttgttaaactccatgaagtccatcgcttcgctgctgcttctgctttttctcttc
atcatcatcttttccttgctggggatgcagctgttcggcggcaagtttaattttgacgag
acccaaaccaagcggagcaccttcgataatttccctcaagcgcttctaacggtgttccag
attctgacaggtgaagactggaacgctgtgatgtatgatggcattatggcatacgggggc
ccgtcgtcttcgggaatgatcgtctgcatctacttcatcatcctcttcatttgtggtaac
tatattctactgaatgtcttcttggccatcgctgtagacaacttggcagatgctgaaagt
ttgaatactgctcagaaagaggaagctgaggaaaaggaaaggaagaagattgccagaaaa
gaaagcctggaaaataaaaagaacaacaaaccagaaatcaaccagatagccaacagtgac
aacaaggtcaccatcgatgactaccgagaagaggatgaggacaaagacccctacccacct
tgtgatgtgccagtaggtgaagaggaagaggaggaggaagaggatgaacccgaggttcct
gctggcccccgtcctcgaagaatgtctgagttgaacatgaaagagaaaatcacccccatc
cccgaagggagcgctttcttcattcttagcaagaccaacccgatccgcgtgggctgccac
aagctcatcaaccaccacatcttcaccaaccttatcctcgtcttcatcatgctgagcagc
gctgccctcgccgccgaggaccccatccgcagccactccttccggaacactatactgggt
tactttgactatgctttcacagccatctttactgttgaaatcctgttgaagatgacgact
ttcggagctttcctccacaaaggggctttctgcaggaactacttcaacttactggatatg
ctggtcgttggggtgtctctggtgtcatttgggatccaatccagtgccatctcagtcgtg
aagatcctgagagtcttaagggttctgagaccgctcagggcaatcaacagagcaaaagga
cttaagcacgtggtccagtgcgtctttgtggccatccggacaattggcaacatcatgatc
gtcaccaccctcctccagttcatgtttgcttgcattggggtgcagctcttcaagggaaag
ttttatcgatgcacagatgaagccaaaagtaaccccgaagaatgcagggggctcttcatc
ctctacaaggatggggatgtcgataaccctgtggtccgtgagaggatctggcaaaacagc
gacttcaactttgacaacgtcctctcagctatgatggctctgttcacggtctccacgttc
gagggctggcccgcgttgctgtacaaggccatcgactcgaacggagagaacgtcggcccc
atctacaactaccgtgtggagatctccatcttcttcatcatctacatcatcatcgtagcg
ttcttcatgatgaacatctttgtgggcttcgtcatcgtcacatttcaggagcagggggag
aaagagtataagaactgtgagctggacaaaaatcagcgtcagtgtgttgaatacgccttg
aaagcacgtcccttgcgaagatacatccccaaaaacccctaccagtacaagttctggtac
gtggtgaactcctcgcctttcgagtacatgatgtttgtcctcatcatgctcaacacactc
tgcttggccatgcagcactacgagcagtccaagatgtttaatgacgccatggacatcctg
aacatggtgttcaccggggtgttcactgtcgagatggttttgaaagtcattgcatttaaa
cctaaggggtactttagtgatgcctggaacacgtttgactccctcatcgtaatcggcagc
attgtagacgtggcgctcagcgaagctgacccaactgaaagtgaaaatgtccctgtccca
actgctacacctgggaactctgaagagagcaatagaatctccatcacctttttccgtctt
ttccgagtgatgcgattggtgaagcttctcagcaggggggaaggcatccggacactgctg
tggacttttattaagtccttccaggcgctcccgtatgtcgcccttctcatcgccatgctg
ttcttcatctacgcggttatcggcatgcagatgtttgggaaagttgccatgagagataac
aaccagatcaacaggaacaacaatttccagacctttccccaggccgtactgctgctcttc
aggtgtgcgacgggggaggcctggcaggaaatcatgctggcctgcctcccgggaaagctc
tgtgaccccgagtccgattacaaccccggggaggagtacacctgcgggagcaactttgcc
attgtttatttcatcagtttttacatgctctgcgcatttctgatcatcaacctgtttgtg
gctgtcatcatggacaatttcgattatctgacccgggactggtctattctggggcctcac
catttagacgaattcaaaagaatatggtccgaatatgaccccgaggcaaagggaagaatc
aagcacctggacgtggtcactctgctccgccgcatccagccccccctggggtttgggaaa
ttgtgtccacacagggtagcctgcaagagactagttgccatgaacatgccgctcaacagt
gacgggacagtcatgtttaatgcaactctgtttgctttggtccgaacggctcttaaaatc
aagacggaagggaacctagaacaagctaatgaagaactccgagctgtgatcaagaaaatc
tggaagaaaaccagcatgaaactgcttgaccaagttgtccctccagctggtgatgatgag
gtaaccgtggggaagttctatgccactttcctgatacaggactactttaggaaattcaag
aaacggaaagaacaaggactggtgggaaaataccccgcgaagagcagcacaattgcccta
caggcgggattaaggacactgcacgacattgggccagaaatccggcgtgctatctcatgt
gatttgcaagatgacgagccggaggaaacaaaaggcgaagaagaagaagatgtgttcaaa
agaaatggtgccctgcttggaaaccatgtcaatcatgttaatagtgataggagagattcc
cttcagcagaccaataccacccaccgtcccctgcatgtccaaaggccttcaattccacct
gcaagtgatactgagaaaccgctgtttcctccagcaggaaattcggtgtgtcataaccat
cataaccataattccataggaaagcaagttcccagctcaacaaatgccaatctcaataat
gccaatatgtccaaagctgcccctggaaaacggcccagcattgggaaccttgagcatgtg
cctgaaaatgggcatcattccttccacaagcatggccgtgagcctcaaagaaggtgcagt
attaaaagaacgcgctattatgaaacttacattagggctgactcaggagacgagcagttc
ccaactatttgccgggaagacccagagatacacggctacttcagggacccctgctgcttg
ggggaacaggagtacttcagcagtgaggagtgctacgaggacgacagctcgcccaccggg
agcaggcagagctacagctgcggctactatacccgatacccaggcagcagcttggacttc
gagcggcctcgaggctaccatcacccccaaagcttctcggaggatgacgactcacctgtt
tgctatgattcccggaggtctccaaggagacgcctgctccctcccaccccaacatccccc
cggagatcctccttcaacttcgagtgcctgcgccggcacagcagccaggaggagttcctg
ccatcccccgccttcccccaccgcacggccctgcctctgcacctgatgcagcaacagatc
atggcagtcgccggcctagattccagtaaagcccagaagtactcgccgagccactccacc
aggtcgtgggccaccccgccagcgaccccgtcgtacagggactggacgccgtgctacacc
ccactgatccaggtcgagcggtcggaggccccggaccaggtcaacggcagcctaccgtcc
ctgcaccgcagctcgtggtacacggacgagcccggcgtctcctatcggacgttcacacca
gccagcctgactgtccccagcagcttccacaacaaaaacagcgacaagcagaggagcgca
gacagcttggtggaggcggttctgatatccgaaggcttaggacggtatgcgagggaccca
aaattcgtgtcagcgacaaaacacgaaatcgccgatgcctgtgacctaaccatcgacgag
atggagagtgcagccagcaacctgctgaacgggaacgtgcatccccgggccaacggggac
gtggggcccgtctcacgccggcaggactacgagctccaggacttcgggcccggctacagc
gacgaggagccagaccccgggagggatgaggaggacctggcggatgaaatgatttgcatc
accaccctgtag

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (35)   
   KEGG PATHWAY (35)   
Genome (1)   
   KEGG GENOME (1)   
Gene (46)   
   KEGG ORTHOLOGY (1)   
   RefGene (42)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (14)   
   RefSeq(pep) (14)   
DNA sequence (14)   
   RefSeq(nuc) (14)   
Protein domain (5)   
   Pfam (5)   
All databases (117)   

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