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KEGG   Oryx dammah (scimitar-horned oryx): 120873247
Entry
120873247         CDS       T07255                                 
Symbol
PLCG2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
  KO
K05859  phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
Organism
oda  Oryx dammah (scimitar-horned oryx)
Pathway
oda00562  Inositol phosphate metabolism
oda01100  Metabolic pathways
oda01521  EGFR tyrosine kinase inhibitor resistance
oda04012  ErbB signaling pathway
oda04014  Ras signaling pathway
oda04020  Calcium signaling pathway
oda04062  Chemokine signaling pathway
oda04064  NF-kappa B signaling pathway
oda04066  HIF-1 signaling pathway
oda04070  Phosphatidylinositol signaling system
oda04072  Phospholipase D signaling pathway
oda04360  Axon guidance
oda04370  VEGF signaling pathway
oda04380  Osteoclast differentiation
oda04611  Platelet activation
oda04613  Neutrophil extracellular trap formation
oda04625  C-type lectin receptor signaling pathway
oda04650  Natural killer cell mediated cytotoxicity
oda04662  B cell receptor signaling pathway
oda04664  Fc epsilon RI signaling pathway
oda04666  Fc gamma R-mediated phagocytosis
oda04670  Leukocyte transendothelial migration
oda04722  Neurotrophin signaling pathway
oda04750  Inflammatory mediator regulation of TRP channels
oda04919  Thyroid hormone signaling pathway
oda04933  AGE-RAGE signaling pathway in diabetic complications
oda04935  Growth hormone synthesis, secretion and action
oda05167  Kaposi sarcoma-associated herpesvirus infection
oda05169  Epstein-Barr virus infection
oda05170  Human immunodeficiency virus 1 infection
oda05171  Coronavirus disease - COVID-19
oda05200  Pathways in cancer
oda05205  Proteoglycans in cancer
oda05206  MicroRNAs in cancer
oda05214  Glioma
oda05223  Non-small cell lung cancer
oda05225  Hepatocellular carcinoma
Module
oda_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:oda00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    120873247 (PLCG2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    120873247 (PLCG2)
   04064 NF-kappa B signaling pathway
    120873247 (PLCG2)
   04066 HIF-1 signaling pathway
    120873247 (PLCG2)
   04070 Phosphatidylinositol signaling system
    120873247 (PLCG2)
   04072 Phospholipase D signaling pathway
    120873247 (PLCG2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    120873247 (PLCG2)
   04613 Neutrophil extracellular trap formation
    120873247 (PLCG2)
   04650 Natural killer cell mediated cytotoxicity
    120873247 (PLCG2)
   04662 B cell receptor signaling pathway
    120873247 (PLCG2)
   04664 Fc epsilon RI signaling pathway
    120873247 (PLCG2)
   04666 Fc gamma R-mediated phagocytosis
    120873247 (PLCG2)
   04670 Leukocyte transendothelial migration
    120873247 (PLCG2)
   04062 Chemokine signaling pathway
    120873247 (PLCG2)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    120873247 (PLCG2)
   04919 Thyroid hormone signaling pathway
    120873247 (PLCG2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    120873247 (PLCG2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    120873247 (PLCG2)
  09158 Development and regeneration
   04360 Axon guidance
    120873247 (PLCG2)
   04380 Osteoclast differentiation
    120873247 (PLCG2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    120873247 (PLCG2)
   05206 MicroRNAs in cancer
    120873247 (PLCG2)
   05205 Proteoglycans in cancer
    120873247 (PLCG2)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    120873247 (PLCG2)
   05214 Glioma
    120873247 (PLCG2)
   05223 Non-small cell lung cancer
    120873247 (PLCG2)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    120873247 (PLCG2)
   05171 Coronavirus disease - COVID-19
    120873247 (PLCG2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    120873247 (PLCG2)
   05169 Epstein-Barr virus infection
    120873247 (PLCG2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    120873247 (PLCG2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    120873247 (PLCG2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:oda04131]
    120873247 (PLCG2)
Enzymes [BR:oda01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     120873247 (PLCG2)
Membrane trafficking [BR:oda04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    120873247 (PLCG2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    120873247 (PLCG2)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 C2 SH3_1 SH3_9 PH PH_12 EF-hand_PLCG1 SH2_1 SH3_2 PH_14 GDPD EF-hand_like
Other DBs
NCBI-GeneID: 120873247
NCBI-ProteinID: XP_040110000
Position
Unknown
AA seq 1262 aa
MANVDTLPEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADKIEG
FLDIMEIKEIRPGKNSKDFERAKAVRQKEECCFTILYGTQFILSTLSLAADSKEDATKWL
SGLKILHQEVMSASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLVNFKVNSAKFL
KDKFLEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFLLGNTDRPDASAVHL
HDFQRFLLHEQQELWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENSIWD
EKYDVVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSTEAYIRCLRMGCRCIELDCWDG
PDGKPIIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCCVEQQRHMARVFKE
VFGDLLLTKPKEASADQLPSPSQLRGKIVIKHKKLGPRGDVDVNMEDKKDEHKQQGELHM
WDPIDQKWTRHYCAIADAKLSFSDDIEQTVEEELPLDIPPTELHFGEKWFHKKVEKRTSA
EKLLQEYCAETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTMKYYLTD
NLMFTSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDGLSRGEAEDMLMRV
PRDGAFLIRKREGTDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYYEKH
ALYRKMKLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDYRAK
QSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISPAEGEEADKQIIEDN
PLGSLCRGILNLNIYNVVKAPHGKNQKPFVFILEPKKQGDPPVEFATDSVEELFEWFQSI
REITWKMDTKENNLKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVETKA
DSIVRQKPSDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTPDKYMQM
NHALFSLNGRTGYVLQPESMRAEKYDPMPPESQRKILMTLTVKVLGARHLPKPGRSIACP
FVEVEICGAEYDNNKFKTTVVNDNGLSPVWAPTQEKVTFEIYDPSLAFLRFVVYEEDMFS
DPNFLAHATYPIKGIKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSCRQL
RRRQEELNNQLFLYDTHQNLRSANRDALVREFNVNENQLQLYQEKCNRRLREKRVSNSKF
YS
NT seq 3789 nt   +upstreamnt  +downstreamnt
atggccaacgtggacaccctcccagagtacgagaagagtcagatcaagcgggccctggag
ctgggcaccgtcatgactgtgttcagcttccgcaagtccaccccggaacggaggaccgtc
caggtgatcatggagacgcggcaggtggcctggagcaagacggctgacaagatcgagggc
ttcctggacatcatggagataaaggagatccggccagggaagaactccaaggatttcgag
cgcgcgaaagcggtccgccagaaggaagagtgctgcttcaccatcctgtacggcacccag
tttatcctcagcacgctcagcctggcagccgactcgaaggaagatgcaactaagtggctg
tctggcttgaagatcttacaccaggaagtgatgagcgcgtccacccccaccatcatcgag
agctggctgagaaagcagatttattctgtggatcaaaccaggagaaacagcatcagcctc
cgggagctgaagaccatcttgcccctggtcaacttcaaagtgaacagtgccaagttcctg
aaagacaagttcctggaaataggcgcacacaaagatgaactcagctttgaacagttccat
ctcttctataaaaaactcatgtttgaacagcagaaatcgatccttgacgaattcaaaaag
gattcttccgtgttcctcttgggcaacaccgaccggccggacgcctctgctgtccacttg
catgacttccagcggtttctcttgcatgaacagcaggagctttgggctcaggatctgaac
aaagtccgtgagcggatgacgaagtttattgacgacaccatgagggaaactgctgaaccc
ttcttgtttgtggatgagttcctcacgtacctgttttcccgggagaacagcatctgggac
gagaagtatgacgtggtggacatgcaggacatgaacaaccccttgtctcattactggatc
tcctcgtctcacaacacgtacctcacgggggaccagctgcggagcgagtcgtccacggag
gcctacatccgctgcctgcggatgggctgccgctgcatcgagctggactgctgggacggg
cccgacggcaagcccatcatctaccacggctggacgcggaccaccaagatcaagttcgac
gacgttgtgcaggccatcaaagaccacgcctttgtcacctccagcttccccgtgatcctg
tccatcgaggagcactgctgtgtggagcagcagcgccacatggccagggtgttcaaggag
gtgtttggagacctgctgctgaccaaacccaaggaggccagtgccgaccagctgccgtcg
cccagccagctgcgcgggaagatcgtcatcaagcataagaagctgggcccccgtggtgac
gtggacgtcaacatggaggacaagaaggacgagcacaagcagcagggcgaactgcacatg
tgggaccccatcgaccagaaatggactcggcactactgtgccattgctgatgccaagctg
tccttcagcgatgacattgaacagactgtggaagaggagctgcccctggatatacccccc
acagagctgcattttggggagaagtggttccacaagaaagtggagaagaggacaagtgcc
gagaagctgctgcaggaatactgcgctgagacagggggcaaggatgggaccttcttggtg
cgggagagtgagactttccccaacgactacaccctgtccttctggcggtcaggccgcgtg
cagcactgccggatccgctccaccatggagggcgggaccatgaagtactacctgaccgac
aacctcatgttcaccagcatctacgccctcatccagcactaccgcgagacacacctgcgc
tgcgccgagttcgagctccggctgaccgaccccgtgcccaaccccaacccgcacgagtcc
aagccgtggtactacgatgggctgagccgcggagaagcggaggacatgctgatgagggtc
ccccgggacggggccttcctgatccggaagcgggaaggtactgactcctacgccatcacc
ttcagggccaggggcaaggtgaagcactgtcgcatcaaccgagacggccggcacttcgtg
ctgggcacctccgcctactttgagagcctcgtggagctggtcagctactatgagaagcat
gcactctaccggaagatgaaactgcgctatcctgtgacccccgagctgctggagcgctac
aacatggaaagagatataaactccctctatgatgtcagcaggatgtatgtggatcccagt
gaaatcaatccttcaatgcctcagagaaccgtgaaagctctgtatgactacagagccaag
cagagtgatgagctgagcttttgccgcggtgccctcatccacaacgtctccaaggagccc
gggggctggtggaaaggagactatgggaccagaatccagcagtacttcccgtccaattat
gtcgaggacatttcaccagcagaaggggaggaggcggataagcagattattgaagacaat
cccttagggtccctttgcagaggaatcctgaatctcaacatctataatgttgttaaagcc
ccacacgggaagaaccagaagcctttcgtctttatcttggagcccaagaagcagggcgac
cctccggtagagtttgccacggacagcgtggaggagctgttcgagtggttccagagcatc
cgggagatcacctggaagatggacaccaaggagaacaacttgaagtactgggagaagaac
cagtccatcgccatcgagctctcggacctggtcgtctactgcaagccaaccagcaagacc
aaggacaacctcgaaaaccctgacttccgagaaatccgctccttcgtggagacgaaggct
gacagtatcgtcagacagaaacccagcgatctcctgaaatacaatcaaaagggcctgacc
cgtgtgtaccccaaaggacagcgggtggactcgtccaactacgaccccttccgcctctgg
ctgtgcggctcccagatggtggcgctcaatttccagactccagataagtacatgcagatg
aaccacgcgctattctccctcaacgggcggacgggctacgtgctgcagcctgagagcatg
agggcggagaagtacgaccccatgccacccgagtcccagaggaagatcctcatgaccctg
acagtcaaggtactgggggcccgtcatctccccaaacccggacgaagcatcgcgtgtccc
tttgtggaggtggagatatgcggagcggagtatgacaacaacaagttcaagacgacagtt
gtgaatgacaatggcctcagccctgtttgggccccaacgcaggagaaggtgacgtttgag
atttatgaccccagccttgcgtttctgcgctttgtggtttatgaggaagatatgttcagc
gatcccaactttctggcccatgccacgtaccccattaaaggaatcaagtcaggatttaga
tctgtgcctctgaagaacggctacagtgaagacattgagctggcgtccctcctggttttc
tgtgagatgcggccagtcctggagagtgaagaggagctgtattcctcctgccgccagctg
cggaggcggcaagaagaactgaacaaccagctctttctgtacgacacccaccagaacctg
cgcagcgccaaccgcgatgccctggtcagagaattcaacgtcaacgagaaccagctgcag
ctgtaccaggagaagtgcaaccgcaggttaagagagaagagagtcagcaacagcaagttt
tactcatag

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (38)   
   KEGG PATHWAY (37)   
   KEGG MODULE (1)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (15)   
   Pfam (15)   
All databases (74)   

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