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KEGG   Neogale vison (American mink): 122911198
Entry
122911198         CDS       T08764                                 
Symbol
PLCG2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1
  KO
K05859  phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
Organism
nvs  Neogale vison (American mink)
Pathway
nvs00562  Inositol phosphate metabolism
nvs01100  Metabolic pathways
nvs01521  EGFR tyrosine kinase inhibitor resistance
nvs04012  ErbB signaling pathway
nvs04014  Ras signaling pathway
nvs04020  Calcium signaling pathway
nvs04062  Chemokine signaling pathway
nvs04064  NF-kappa B signaling pathway
nvs04066  HIF-1 signaling pathway
nvs04070  Phosphatidylinositol signaling system
nvs04072  Phospholipase D signaling pathway
nvs04360  Axon guidance
nvs04370  VEGF signaling pathway
nvs04380  Osteoclast differentiation
nvs04611  Platelet activation
nvs04613  Neutrophil extracellular trap formation
nvs04625  C-type lectin receptor signaling pathway
nvs04650  Natural killer cell mediated cytotoxicity
nvs04662  B cell receptor signaling pathway
nvs04664  Fc epsilon RI signaling pathway
nvs04666  Fc gamma R-mediated phagocytosis
nvs04670  Leukocyte transendothelial migration
nvs04722  Neurotrophin signaling pathway
nvs04750  Inflammatory mediator regulation of TRP channels
nvs04919  Thyroid hormone signaling pathway
nvs04933  AGE-RAGE signaling pathway in diabetic complications
nvs04935  Growth hormone synthesis, secretion and action
nvs05167  Kaposi sarcoma-associated herpesvirus infection
nvs05169  Epstein-Barr virus infection
nvs05170  Human immunodeficiency virus 1 infection
nvs05171  Coronavirus disease - COVID-19
nvs05200  Pathways in cancer
nvs05205  Proteoglycans in cancer
nvs05206  MicroRNAs in cancer
nvs05214  Glioma
nvs05223  Non-small cell lung cancer
nvs05225  Hepatocellular carcinoma
Module
nvs_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:nvs00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    122911198 (PLCG2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    122911198 (PLCG2)
   04064 NF-kappa B signaling pathway
    122911198 (PLCG2)
   04066 HIF-1 signaling pathway
    122911198 (PLCG2)
   04070 Phosphatidylinositol signaling system
    122911198 (PLCG2)
   04072 Phospholipase D signaling pathway
    122911198 (PLCG2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    122911198 (PLCG2)
   04613 Neutrophil extracellular trap formation
    122911198 (PLCG2)
   04650 Natural killer cell mediated cytotoxicity
    122911198 (PLCG2)
   04662 B cell receptor signaling pathway
    122911198 (PLCG2)
   04664 Fc epsilon RI signaling pathway
    122911198 (PLCG2)
   04666 Fc gamma R-mediated phagocytosis
    122911198 (PLCG2)
   04670 Leukocyte transendothelial migration
    122911198 (PLCG2)
   04062 Chemokine signaling pathway
    122911198 (PLCG2)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    122911198 (PLCG2)
   04919 Thyroid hormone signaling pathway
    122911198 (PLCG2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    122911198 (PLCG2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    122911198 (PLCG2)
  09158 Development and regeneration
   04360 Axon guidance
    122911198 (PLCG2)
   04380 Osteoclast differentiation
    122911198 (PLCG2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    122911198 (PLCG2)
   05206 MicroRNAs in cancer
    122911198 (PLCG2)
   05205 Proteoglycans in cancer
    122911198 (PLCG2)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    122911198 (PLCG2)
   05214 Glioma
    122911198 (PLCG2)
   05223 Non-small cell lung cancer
    122911198 (PLCG2)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    122911198 (PLCG2)
   05171 Coronavirus disease - COVID-19
    122911198 (PLCG2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    122911198 (PLCG2)
   05169 Epstein-Barr virus infection
    122911198 (PLCG2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    122911198 (PLCG2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    122911198 (PLCG2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:nvs04131]
    122911198 (PLCG2)
Enzymes [BR:nvs01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     122911198 (PLCG2)
Membrane trafficking [BR:nvs04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    122911198 (PLCG2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    122911198 (PLCG2)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 C2 SH3_1 PH SH3_9 EF-hand_PLCG1 PH_12 SH2_1 SH3_2 PH_14 GDPD EF-hand_like
Other DBs
NCBI-GeneID: 122911198
NCBI-ProteinID: XP_044111599
Position
7:complement(6160624..6302549)
AA seq 1265 aa
MTAPANVDTLPEHEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADK
IEGFLDIMEIKEIRPGKNSKDFERAKVVHQKKDCCFTIFYGTQFVLSTLSLAADSKEDAT
KWLSGLKILHQEAMSASTPTIIESWLRKQIYSVDQTRRNSISLRELKSILPLVNFKVSSA
KFLKDKFVEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASA
VYLHDFQRFLLHEQQELWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENS
IWDEKYDVVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSTEAYIRCLRAGCRCIELDC
WDGPDGKPIIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCCVEQQRHMARV
FKEVFGDQLLTKPTEASADQLPSPSQLREKFIIKHKKLGPRGDVDVNMEDKKDEHKQQGE
LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTAEEELPQDIPPTELHFGEEWFHKKVEKR
TSAERLLQEYCAETGGKDGTFLVRESKTFPNDYTLSFWRSGRVQHCRIRSTMEGGTMKYF
LTDNVTFTSIYDLIQHYRETHLRCTEFELRLTDPVPNPNPHESKPWYYDGLSRGEAEDML
MRVPRDGAFLIRRREGTDSYAITFRARGKVKHCRIHRDGRHFVLGTSAYFESLVELVSYY
EKHALYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEISPSMPQRTVKALYDY
KAKRNDELSFCRGALIHNVSKEPWGWWKGDYGTRIQQYFPSNYVEDISTADVEELEKQII
EDNPLGSLCRGILDLNTYNVVKAPHGKNQKQFVFILEPKKQGDPPVEFATDRVEELFEWF
QSIREITWKMDTKENSMKYWEKNQSIAIELSDLVVYCKPTSKAKDNLENPDFREIRSFVE
TKADSVVRQKPVDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTPDKY
MQMNHALFSLNGRTGYVLQPESMRSEQYDPMPPESQRKILMTLSVKVLGARHLPKLGRSI
ACPFVEVEICGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEED
MFSDPNFLAHATYPIKGIKSGFRSVPLKNGYSEDIELASLLVFCEMQPVLESEEELYSSC
RQLRRRQEELNNQLFLYDTHQNLRNANRDALVKEFNVNENQLQLYQEKCNRRLREKRVSN
SRFYS
NT seq 3798 nt   +upstreamnt  +downstreamnt
atgactgccccggccaacgtggacaccctccccgagcacgagaagagtcagatcaagagg
gcgctggagctgggcacagtgatgacggtgttcagcttccgcaagtccaccccggagcgg
aggaccgtccaagtcatcatggagacccgccaggtggcctggagcaagaccgccgacaag
atcgagggtttcttggatatcatggaaatcaaggaaatccgccccgggaagaactccaag
gattttgagcgtgcaaaggttgtgcatcagaagaaagactgctgcttcaccatcttctac
gggacccagttcgtcctcagcaccctcagcttggcagccgactctaaggaggatgcgact
aagtggctctcgggcttgaaaatcttacaccaggaagcgatgagcgcgtctacacccacc
atcattgagagctggctgagaaagcagatctattcagtggatcaaaccagaagaaacagc
atcagcctccgagagttgaagagcatcttacccctggtcaacttcaaagtgagcagtgcc
aagttcctcaaagataagtttgtggaaattggtgcacacaaagatgaactcagctttgag
cagttccacctgttctataaaaaacttatgtttgagcagcaaaagtcgattcttgacgaa
ttcaaaaaagattcttctgtgttcatcttgggcaacaccgaccggccggacgcctccgcg
gtttacctgcacgacttccagcgctttctcttacacgagcagcaggagctttgggctcaa
gatctgaacaaagtccgagagcggatgactaagttcatcgatgacaccatgcgggagact
gccgagcccttcctgtttgtcgatgagttcctcacgtacctcttttcgcgggagaacagc
atctgggatgagaagtacgacgtggtggacatgcaggacatgaacaaccccttgtcccat
tactggatctcctcttcgcataacacgtacctcaccggcgaccagctgcggagcgagtcg
tccacagaagcctacatccgctgcctgcgggcgggctgccgctgcattgagctggactgc
tgggacgggcctgacgggaagcccatcatctaccatggctggacacggaccaccaagatc
aagtttgatgacgtcgtgcaggccatcaaagaccatgcctttgtcacctccagcttccca
gtgatcctgtccattgaggagcactgttgcgtggagcagcagcgccacatggcccgggtg
ttcaaggaggtgtttggcgaccagctgctgacgaagcccacggaggccagcgctgaccag
ctgccctcacccagccagctgcgggagaagttcatcatcaagcataagaagctgggtccc
cggggcgacgtggatgtcaacatggaggacaagaaggatgagcacaagcaacagggtgaa
ctgtacatgtgggattccatcgaccagaaatggacccggcactactgtgccatcgccgat
gccaagctgtcgttcagcgacgacattgaacagacagcagaagaggaactgccccaggat
ataccccctacagagctgcattttggggaggagtggttccacaagaaggtggagaagaga
accagcgccgagaggctgctgcaggagtactgtgcggagacggggggcaaagacgggacc
ttcctggtgcgagagagcaagaccttccccaacgactacaccctgtccttctggcggtct
ggccgggtccagcactgccggatccgttccaccatggagggtgggaccatgaagtacttc
ctgaccgacaacgtcacgttcaccagcatctatgacctcatccagcattaccgcgagacg
cacctgcgctgcaccgagttcgagcttcggctcaccgaccccgtgcccaaccccaacccc
cacgagtcaaagccgtggtactacgacgggctgagccgcggggaagcggaggacatgctg
atgagagttccccgggacggcgccttcctcatccggaggcgggagggcaccgactcgtac
gccatcaccttcagggccaggggcaaggtcaagcactgccgcatccaccgggacggccgg
cacttcgtgctggggacctcggcctacttcgagagcctcgtggagctcgtgagctactac
gagaagcacgcgctgtaccggaagatgcggctgcgctaccccgtgacgccggagctcctg
gagcgctacaacatggaaagagacataaactccctttacgacgtcagcagaatgtatgtg
gatcccagtgaaatcagtccctccatgcctcagagaactgtgaaagctctgtatgactac
aaagccaagcggaacgatgagttgagcttctgccgtggggccctcattcacaacgtctcc
aaggagccctggggctggtggaaaggggactatggaaccagaatccagcagtacttcccg
tccaattacgtcgaggacatttcaacagccgacgtggaggagctggagaagcagattatt
gaggacaatcccttagggtctctctgtcggggaatattggatctcaacacctataacgtg
gtgaaagcgccccacgggaagaaccagaagcagttcgtgttcatcctggagcccaagaag
caaggcgaccccccggtggagttcgccacggacagggtggaggagctcttcgagtggttt
cagagtatccgggagatcacgtggaagatggacaccaaggagaacagcatgaagtactgg
gagaagaaccagtccatcgccatcgagctctcggacctggtcgtctactgcaagccgacc
agcaaggccaaggacaatctcgaaaaccccgacttccgagaaatccgctcctttgtggag
acgaaggcggacagtgtcgtcaggcagaaacccgtcgacctcctgaagtacaaccagaag
ggcctgactcgagtttaccccaagggacagagggtggactcctccaactatgaccccttt
cgcctctggctgtgcggctcccagatggtggctctcaatttccagactccagataagtac
atgcagatgaaccacgccttgttctcactcaatggtcgcacgggctacgtcctccagccc
gagagcatgaggtccgagcagtacgacccgatgcctcccgagtcccagagaaagatcttg
atgactctgtcggtcaaggttctcggggctcgccatctccccaaacttggacgaagtatt
gcgtgtccctttgtggaggtggagatttgtggagctgagtatgacaacaacaagtttaag
acaacagttgtgaatgacaatggcctcagcccgatttgggctccaacacaggagaaagtg
acttttgaaatttatgaccccaacctggcgtttctgcgttttgtcgtctacgaggaagat
atgttcagtgatcccaacttccttgcccacgccacttaccccatcaaaggaatcaaatcg
ggattcagatctgttcctctgaagaacgggtacagtgaagacatcgagctggcttccctc
ctggttttctgtgagatgcagccagtcctggagagcgaagaggagctgtactcctcctgc
cgccagctgcgaaggcggcaggaagagctaaacaatcagctctttctgtacgacacacac
cagaacttgcgcaatgccaaccgggacgccctcgttaaagagttcaatgtcaacgagaac
cagctccagctgtaccaggagaagtgcaaccggaggttgagagagaagagagtcagcaac
agcaggttttactcctag

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (38)   
   KEGG PATHWAY (37)   
   KEGG MODULE (1)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (3)   
   RefSeq(pep) (3)   
DNA sequence (5)   
   RefSeq(nuc) (3)   
   GenBank (1)   
   EMBL (1)   
Protein domain (15)   
   Pfam (15)   
All databases (80)   

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