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KEGG   ORTHOLOGY: K22273
Entry
K22273            Tight     KO                                     
Symbol
NS3
Name
Hepatitis C virus serine protease / helicase NS3 [EC:3.4.21.98 3.6.1.15 5.6.2.6]
Pathway
map03230  Viral genome structure
map03240  Viral replication
map03272  Virion - Hepatitis viruses
map05160  Hepatitis C
map05203  Viral carcinogenesis
Network
nt06163  Hepatitis C virus (HCV)
nt06263  Hepatocellular carcinoma
nt06517  TLR signaling
nt06519  RLR signaling
nt06524  Apoptosis
  Element
N00271  HCV NS3/4A to RIG-I-like receptor signaling pathway
N00516  HCV NS3/4A to TLR3-IRF3 signaling pathway
N00517  HCV NS3/4A to TLR3-IRF3 signaling pathway
N00522  HCV NS3 to p21-cell cycle G1/S
N00526  HCV NS3 to crosstalk between extrinsic and intrinsic apoptotic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03230 Viral genome structure
    K22273  NS3; Hepatitis C virus serine protease / helicase NS3
   03240 Viral replication
    K22273  NS3; Hepatitis C virus serine protease / helicase NS3
   03272 Virion - Hepatitis viruses
    K22273  NS3; Hepatitis C virus serine protease / helicase NS3
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    K22273  NS3; Hepatitis C virus serine protease / helicase NS3
  09172 Infectious disease: viral
   05160 Hepatitis C
    K22273  NS3; Hepatitis C virus serine protease / helicase NS3
 09180 Brite Hierarchies
  09185 Viral protein families
   03200 Viral proteins
    K22273  NS3; Hepatitis C virus serine protease / helicase NS3
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.98  hepacivirin
     K22273  NS3; Hepatitis C virus serine protease / helicase NS3
  3.6  Acting on acid anhydrides
   3.6.1  In phosphorus-containing anhydrides
    3.6.1.15  nucleoside-triphosphate phosphatase
     K22273  NS3; Hepatitis C virus serine protease / helicase NS3
 5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.6  RNA 3'-5' helicase
     K22273  NS3; Hepatitis C virus serine protease / helicase NS3
Viral proteins [BR:ko03200]
 +ssRNA viruses
  Hepatitis C virus (Hepacivirus C)
   K22273  NS3; Hepatitis C virus serine protease / helicase NS3
Other DBs
GO: 0017111 0034458
Genes
VP: 951475-6(NS3)
Reference
PMID:8861916
  Authors
Love RA, Parge HE, Wickersham JA, Hostomsky Z, Habuka N, Moomaw EW, Adachi T, Hostomska Z
  Title
The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site.
  Journal
Cell 87:331-42 (1996)
DOI:10.1016/s0092-8674(00)81350-1
  Sequence
[vp:951475-6]
Reference
PMID:23836234
  Authors
Scheel TK, Rice CM
  Title
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies.
  Journal
Nat Med 19:837-49 (2013)
DOI:10.1038/nm.3248

  All links  
Ontology (5)   
   KEGG BRITE (3)   
   GO (2)   
Pathway (10)   
   KEGG PATHWAY (10)   
Network (10)   
   KEGG NETWORK (10)   
Drug (28)   
   KEGG DRUG (28)   
Chemical reaction (3)   
   KEGG ENZYME (3)   
Gene (1)   
   KEGG GENES (1)   
Literature (2)   
   PubMed (2)   
All databases (59)   

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KEGG   ORTHOLOGY: K22274
Entry
K22274            Tight     KO                                     
Symbol
NS4A
Name
Hepatitis C virus non-structural protein 4A
Pathway
map03230  Viral genome structure
map03240  Viral replication
map03272  Virion - Hepatitis viruses
map05160  Hepatitis C
Network
nt06163  Hepatitis C virus (HCV)
nt06263  Hepatocellular carcinoma
nt06517  TLR signaling
nt06519  RLR signaling
  Element
N00271  HCV NS3/4A to RIG-I-like receptor signaling pathway
N00516  HCV NS3/4A to TLR3-IRF3 signaling pathway
N00517  HCV NS3/4A to TLR3-IRF3 signaling pathway
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03230 Viral genome structure
    K22274  NS4A; Hepatitis C virus non-structural protein 4A
   03240 Viral replication
    K22274  NS4A; Hepatitis C virus non-structural protein 4A
   03272 Virion - Hepatitis viruses
    K22274  NS4A; Hepatitis C virus non-structural protein 4A
 09160 Human Diseases
  09172 Infectious disease: viral
   05160 Hepatitis C
    K22274  NS4A; Hepatitis C virus non-structural protein 4A
 09180 Brite Hierarchies
  09185 Viral protein families
   03200 Viral proteins
    K22274  NS4A; Hepatitis C virus non-structural protein 4A
Viral proteins [BR:ko03200]
 +ssRNA viruses
  Hepatitis C virus (Hepacivirus C)
   K22274  NS4A; Hepatitis C virus non-structural protein 4A
Genes
VP: 951475-7(NS4A)
Reference
PMID:27928005
  Authors
Murayama A, Sugiyama N, Suzuki R, Moriyama M, Nakamura N, Mochizuki H, Wakita T, Kato T
  Title
Amino Acid Mutations in the NS4A Region of Hepatitis C Virus Contribute to Viral Replication and Infectious Virus Production.
  Journal
J Virol 91:e02124-16 (2017)
DOI:10.1128/JVI.02124-16
  Sequence
[vp:951475-7]
Reference
PMID:23836234
  Authors
Scheel TK, Rice CM
  Title
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies.
  Journal
Nat Med 19:837-49 (2013)
DOI:10.1038/nm.3248

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (8)   
   KEGG PATHWAY (8)   
Network (7)   
   KEGG NETWORK (7)   
Drug (28)   
   KEGG DRUG (28)   
Gene (1)   
   KEGG GENES (1)   
Literature (2)   
   PubMed (2)   
All databases (48)   

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