KEGG ORTHOLOGY: K18496

ORTHOLOGY: K18496

Entry

K18496                      KO

Symbol

FGF1

Name

fibroblast growth factor 1

Pathway

map04010

MAPK signaling pathway

map04014

Ras signaling pathway

map04015

Rap1 signaling pathway

map04020

Calcium signaling pathway

map04151

PI3K-Akt signaling pathway

map04390

Hippo signaling pathway

map04810

Regulation of actin cytoskeleton

map05200

Pathways in cancer

map05218

Melanoma

map05224

Breast cancer

map05226

Gastric cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K18496  FGF1; fibroblast growth factor 1
   04014 Ras signaling pathway
    K18496  FGF1; fibroblast growth factor 1
   04015 Rap1 signaling pathway
    K18496  FGF1; fibroblast growth factor 1
   04390 Hippo signaling pathway
    K18496  FGF1; fibroblast growth factor 1
   04020 Calcium signaling pathway
    K18496  FGF1; fibroblast growth factor 1
   04151 PI3K-Akt signaling pathway
    K18496  FGF1; fibroblast growth factor 1
09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K18496  FGF1; fibroblast growth factor 1
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K18496  FGF1; fibroblast growth factor 1
  09162 Cancer: specific types
   05226 Gastric cancer
    K18496  FGF1; fibroblast growth factor 1
   05218 Melanoma
    K18496  FGF1; fibroblast growth factor 1
   05224 Breast cancer
    K18496  FGF1; fibroblast growth factor 1
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K18496  FGF1; fibroblast growth factor 1
   00536 Glycosaminoglycan binding proteins
    K18496  FGF1; fibroblast growth factor 1
Cytokines and neuropeptides [BR:ko04052]
Cytokines
  Growth factors (RTK binding)
   K18496  FGF1; fibroblast growth factor 1
Glycosaminoglycan binding proteins [BR:ko00536]
Heparan sulfate / Heparin
  Growth factors/receptors
   K18496  FGF1; fibroblast growth factor 1

Other DBs

GO:

0005104

Genes

HSA:	2246(FGF1)

PTR:	462158(FGF1)

PPS:	100972676(FGF1)

PON:	100174103(FGF1)

PPYG:

129036937(FGF1)

NLE:	100603200(FGF1)

HMH:	116471654(FGF1)

SSYN:

129486231(FGF1)

MCC:	705970(FGF1)

MTHB:

126957258

MNI:	105466960(FGF1)

CSAB:

103244714(FGF1)

CATY:

105599949(FGF1)

PANU:

100137595(FGF1)

TGE:	112626218(FGF1)

MLEU:

105549556(FGF1)

RRO:	104681837(FGF1)

RBB:	108530219(FGF1)

TFN:	117065686(FGF1)

PTEH:

111523283(FGF1)

CANG:

105510120(FGF1)

CJC:	100392014(FGF1)

SBQ:	101040924(FGF1)

CIMI:

108307097(FGF1)

ANAN:

105722829(FGF1)

CSYR:

103251528(FGF1)

MMUR:

105862501(FGF1)

LCAT:

123637917(FGF1)

PCOQ:

105811549(FGF1)

OGA:	100966077(FGF1)

MMU:	14164(Fgf1)

MCAL:

110284837(Fgf1)

MPAH:

110333309(Fgf1)

RNO:	25317(Fgf1)

MCOC:

116087087(Fgf1)

ANU:	117720104(Fgf1)

ASYL:

127663940(Fgf1)

MUN:	110559286(Fgf1)

CGE:	100764257(Fgf1)

MAUA:

101823630(Fgf1)

PROB:

127234192(Fgf1)

PLEU:

114708354(Fgf1)

MORG:

121445340 121453630(Fgf1)

MFOT:

126513226

AAMP:

119814061(Fgf1)

NGI:	103736084(Fgf1)

HGL:	101717777(Fgf1)

CPOC:

100727152(Fgf1)

CCAN:

109684968(Fgf1) 109684969

DORD:

105988744(Fgf1)

DSP:	122118224(Fgf1)

PLOP:

125339912(Fgf1)

NCAR:

124987262

MMMA:

107142266(Fgf1)

ITI:	101956072(Fgf1)

OCU:	100328898(FGF1)

OPI:	101529368(FGF1)

TUP:	102472932(FGF1)

GVR:	103590682(FGF1)

CFA:	607724(FGF1)

CLUD:

112659082(FGF1)

VVP:	112934748(FGF1)

VLG:	121496849(FGF1)

NPO:	129514194(FGF1)

AML:	100463878(FGF1)

UMR:	103663709(FGF1)

UAH:	113255360(FGF1)

UAR:	123790206(FGF1)

ELK:

111156955

LLV:

125100276

MPUF:

101689861(FGF1)

MNP:	132028621(FGF1)

MLK:	131832196(FGF1)

NVS:	122889883(FGF1)

ORO:	101363195(FGF1)

EJU:	114200671(FGF1)

ZCA:	113928886(FGF1)

MLX:	118016762(FGF1)

NSU:	110590990(FGF1)

LWW:

102749895

FCA:	101082206(FGF1)

PYU:	121016402(FGF1)

PCOO:

112861306(FGF1)

PBG:	122488446(FGF1)

PVIV:

125176643(FGF1)

LRUF:

124517067

PTG:	102967663(FGF1)

PPAD:

109252228(FGF1)

PUC:

125934898

AJU:

106967134

HHV:	120234333(FGF1)

BTA:	281160(FGF1)

BOM:	102287352(FGF1)

BIU:	109562156(FGF1)

BBUB:

102393179(FGF1)

BBIS:

104996248(FGF1)

CHX:	102188850(FGF1)

OAS:	101109353(FGF1)

BTAX:

128050845(FGF1)

CSUM:

138086035(FGF1)

ODA:	120863516(FGF1)

CCAD:

122439770(FGF1)

MREE:

136156240(FGF1)

MBEZ:

129559536(FGF1)

SSC:	397497(FGF1)

CFR:	102513829(FGF1)

CBAI:

105065479(FGF1)

CDK:	105090819(FGF1)

VPC:	102536166(FGF1)

BACU:

103018997(FGF1)

BMUS:

118892913(FGF1)

LVE:	103090095(FGF1)

OOR:	101277714(FGF1)

DLE:	111183039(FGF1)

PCAD:

102979009(FGF1)

PSIU:

116751451(FGF1)

NASI:

112404439(FGF1)

ECB:	100033960(FGF1)

EPZ:	103550265(FGF1)

EAI:	106836975(FGF1)

MYB:	102256157(FGF1)

MYD:	102766495(FGF1)

MMYO:

118658742(FGF1)

MLF:	102431344(FGF1)

MDT:	132235794(FGF1)

PKL:	118711036(FGF1)

EFUS:

103285537(FGF1)

MNA:	107531500(FGF1)

DRO:	112318067(FGF1)

SHON:

118998653(FGF1)

AJM:	119046588(FGF1)

PDIC:

114510422(FGF1)

PHAS:

123810790(FGF1)

MMF:	118616081(FGF1)

PPAM:

129066585(FGF1)

HAI:	109393705(FGF1)

RFQ:	117016625(FGF1)

PALE:

102894192(FGF1)

PGIG:

120581479(FGF1)

PVP:	105297044(FGF1)

RAY:	107500865(FGF1)

TOD:	119243330(FGF1)

SARA:

101548050(FGF1)

SFUM:

130033129(FGF1)

SETR:

126027928(FGF1)

LAV:	100663763(FGF1)

TMU:

101359380

ETF:	101654974(FGF1)

DNM:	101425751(FGF1)

MDO:	100023197(FGF1)

GAS:	123235626(FGF1)

SHR:	100929695(FGF1)

AFZ:

127550053

PCW:	110220894(FGF1)

TVP:	118841727(FGF1)

PBRV:

138172811(FGF1)

OAA:	100078822(FGF1)

GGA:	396094(FGF1)

PCOC:

116232254(FGF1)

MGP:	100551381 104913334

CJO:	107320055(FGF1)

TPAI:

128083930(FGF1)

LMUT:

125700187(FGF1)

NMEL:

110405391(FGF1)

APLA:

101794210(FGF1)

ACYG:

106032819(FGF1)

CATA:

118254886(FGF1)

AFUL:

116494876(FGF1)

TGU:	105759362(FGF1)

LSR:	110476395(FGF1)

SCAN:

103817397(FGF1)

PMOA:

120498504(FGF1)

OTC:	121332343(FGF1)

PRUF:

121365607(FGF1)

GFR:	102031991(FGF1)

FAB:	101817673(FGF1)

OMA:	130258852(FGF1)

PHI:	102103492(FGF1)

PMAJ:

107210662(FGF1)

CCAE:

111935800(FGF1)

CCW:	104689475(FGF1)

CBRC:

103611495(FGF1)

ACOE:

138117970(FGF1)

ETL:	114066997(FGF1)

ZAB:	102066436(FGF1)

ZLE:	135453843(FGF1)

ACHL:

103805303(FGF1)

SVG:	106860480(FGF1)

MMEA:

130583414(FGF1)

HRT:	120759139(FGF1)

SATI:

136367652(FGF1)

FPG:	101922474(FGF1)

FCH:	102051939(FGF1)

NNT:	104408101(FGF1)

SHAB:

115615723(FGF1)

ACUN:

113485315(FGF1)

TALA:

104359466(FGF1)

ACHC:

115334052(FGF1)

AGEN:

126050933

HHAR:

128155102(FGF1)

GCL:

127021988

CSTI:

104562909(FGF1)

LDI:	104348522(FGF1)

MNB:	103777588(FGF1)

DPUB:

104301868(FGF1)

PPUS:

135185169(FGF1)

AVIT:

104279017(FGF1)

BRHI:

104492219 104502307

EGZ:	104133414(FGF1)

NNI:	104012024(FGF1)

PADL:

103923131(FGF1)

AFOR:

103904460(FGF1)

FGA:

104077941

CLV:	102091153(FGF1)

MUI:	104545729(FGF1)

PGUU:

104469844(FGF1)

EHS:	104515180(FGF1)

CMAC:

104476880(FGF1)

CUCA:

104060442(FGF1)

TEO:	104376738(FGF1)

BREG:

104643806(FGF1)

OHA:	104327497(FGF1)

ACAR:

104523120(FGF1)

CPEA:

104391881(FGF1)

CVF:	104291377(FGF1)

RTD:	128916278(FGF1)

AAM:	106487164(FGF1)

AROW:

112964827(FGF1)

NPD:	112952766(FGF1)

TGT:	104565977(FGF1)

DNE:	112994049(FGF1)

ASN:	102367772(FGF1)

AMJ:	102570160(FGF1)

CPOO:

109310053(FGF1)

GGN:	109289995(FGF1)

PSS:	102452758(FGF1)

CMY:	102931997(FGF1)

CCAY:

125641631(FGF1)

DCC:	119860187(FGF1)

CPIC:

101933626(FGF1)

TST:	117881750(FGF1)

CABI:

116818340(FGF1)

MRV:	120370342(FGF1)

ACS:	100564309(fgf1)

ASAO:

132768852(FGF1)

PVT:	110086304(FGF1)

SUND:

121920223(FGF1)

PBI:	103048921(FGF1)

PMUR:

107301319(FGF1)

CTIG:

120311434(FGF1)

PGUT:

117656644(FGF1)

APRI:

131193324(FGF1)

PTEX:

113433550(FGF1)

NSS:	113423689(FGF1)

VKO:	123035817(FGF1)

PMUA:

114591226(FGF1)

PRAF:

128407839(FGF1)

ZVI:	118080327(FGF1)

HCG:	128341613(FGF1)

GJA:	107113068(FGF1)

STOW:

125429560(FGF1)

EMC:	129328391(FGF1)

XLA:	108712499(fgf1.S) 444686(fgf1.L)

XTR:	100217324(fgf1)

NPR:	108794559(FGF1)

RTEM:

120932310(FGF1)

BBUF:

120977848(FGF1)

BGAR:

122926404(FGF1)

MUO:	115476429(FGF1)

GSH:	117351825(FGF1)

DRE:	100005049(fgf1b) 393733(fgf1a)

SRX:	107713127 107727259 107741080 107756685

SANH:

107661717 107664758

SGH:	107554712 107558456 107582013 107587303

CCAR:

109070121 109109517(fgf1) 109111438

CAUA:

113038322 113114304

CGIB:

127971078 127985721

PTET:

122326704(fgf1b) 122357455(fgf1a)

LROH:

127152732(fgf1b) 127176456(fgf1a)

OMC:	131529050(fgf1b) 131553762(fgf1a)

PPRM:

120460648(fgf1a) 120461945(fgf1b)

RKG:	130073612(fgf1b) 130084717(fgf1a)

MAMB:

125253550(fgf1b) 125259438(fgf1a)

CIDE:

127494177 127504117

CERY:

137004626(fgf1a) 137012913(fgf1b)

MASI:

127412673 127429372

TROS:

130563979(fgf1a) 130570429(fgf1b)

TDW:	130407475 130407476(fgf1b) 130438074(fgf1a)

MANU:

129422265(fgf1a) 129423906(fgf1b)

IPU:	100528431(fgf1a) 108278801(fgf1b)

IFU:	128617662(fgf1a) 128622447(fgf1b)

PHYP:

113530070 113541732(fgf1)

SMEO:

124392666(fgf1a) 124398076(fgf1b)

TFD:	125139862(fgf1b)

TVC:	132859949(fgf1b)

TRN:	134319665(fgf1a) 134330405(fgf1b)

AMEX:

103027348(fgf1a) 103038135(fgf1b)

CMAO:

118811423(fgf1a) 118820141(fgf1b)

EEE:	113585519(fgf1)

CHAR:

105902783 105909155

TRU:

101069995

TFS:	130530938(fgf1a)

TNG:	GSTEN00017026G001 GSTEN00033767G001

LCO:	104917779(fgf1) 104938805

NCC:	104943539 104966015

TBEN:

117475213(fgf1a) 117490778

CGOB:

115014730 115019345(fgf1)

PGEO:

117454272(fgf1a) 117458688

GACU:

117540091 117556016(fgf1a)

EMAC:

134860323(fgf1a) 134872674

ELY:	117261259(fgf1a) 117265400

EFO:	125894303(fgf1a) 125898461

PLEP:

121948266(fgf1a) 121952412

SLUC:

116037089 116064288(fgf1a)

ECRA:

117951719 117955760

ESP:	116696922 116700286(fgf1)

PFLV:

114562676 114566759(fgf1)

GAT:	120816997(fgf1a) 120822726

PPUG:

119210693 119215959

AFB:	129090404(fgf1a) 129113674

CLUM:

117737310(fgf1a) 117742265

PSWI:

130210207(fgf1a)

CANA:

137790955(fgf1a) 137802760

CVE:	137875388(fgf1a) 137876282

MSAM:

119889029 119895886

SCHU:

122879980(fgf1a) 122888753

CUD:	121516604(fgf1a) 121518905

SPUL:

138597987(fgf1a) 138601146

ALAT:

119007710(fgf1a) 119031782

ASTR:

137602977(fgf1a) 137606141

MZE:	101468745 101481636(fgf1)

ONL:	100693787 100705330(fgf1)

OAU:	116309367 116324528(fgf1a)

OLA:	101161650 101168387(fgf1)

OML:	112143069 112153803(fgf1a)

CSAI:

133446896(fgf1a) 133460212

XMA:	102217141 102220806(fgf1)

XCO:	114139185 114152626(fgf1)

XHE:	116714009 116728043

PRET:

103471210 103475366(fgf1)

PFOR:

103135584 103144902

PLAI:

106950541 106955382

PMEI:

106919274 106925627

GAF:	122832774 122837375(fgf1a) 122844537

PPRL:

129362454(fgf1a) 129373597

CVG:	107089939 107101656

CTUL:

119787960 119792519

GMU:	124860400(fgf1a) 124876079

NFU:	107375089 107386707(fgf1)

KMR:	108238930 108240579(fgf1a)

ALIM:

106523408 106534413(fgf1)

NWH:	119408511(fgf1a) 119419931

AOCE:

111565146 111567558 111583868

EJA:	138195908 138211620(fgf1a)

BFRE:

138620147(fgf1a) 138635074

MCEP:

125008332(fgf1a) 125020970

CSEM:

103391194 103395214

POV:	109635763(fgf1) 109645500

SSEN:

122760023 122762527

HHIP:

117769640(fgf1a) 117774933

HSP:	118112587(fgf1a) 118121838

PPLT:

128446170(fgf1a) 128457250

SMAU:

118300639 118319415(fgf1a)

LCF:	108882928(fgf1a) 108893486

SDU:	111226537 111234449

SLAL:

111652698 111672059

XGL:	120785481(fgf1a) 120802102

HCQ:	109515764 109517974

SSCV:

125982465

SBIA:

133492212 133508865(fgf1a)

PEE:	133407634(fgf1a) 133415954

PTAO:

133467603 133484434(fgf1a)

BPEC:

110160403 110162910

MALB:

109959975(fgf1) 109971167

BSPL:

114863958(fgf1a)

SJO:	128362703(fgf1a) 128371216

SSCO:

133985629(fgf1a) 133993890

SASA:

100196882(fgf1) 106603858(FGF1)

STRU:

115153981 115167514

OTW:	112221240 112228298

OMY:	110489170(fgf1a) 110533350

OGO:	123993700 123994992

ONE:	115124726 115125894

OKI:	109872501 109878330

OKE:	118381612 118389805

SALP:

111950164 111980315 112069820 112070232

SNH:	120047375 120056452

CCLU:

121531070 121545721 121579201

ELS:	105011240 105025969

SFM:	108936823(fgf1)

PKI:

111833360

AANG:

118236357

CCOG:

133133151

LOC:	102692817(fgf1)

PSPA:

121296940

ARUT:

117431342 117962906

PSEX:

120543141

LCM:	102355138(FGF1)

CMK:	103184127(fgf1)

RTP:

CPLA:

HOC:

LERI:

PMRN:

LRJ:

BFO:

BBEL:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

PBAR:

HST:

CFO:

FEX:

LHU:

OBO:

PCF:

PFUC:

VPS:

VVE:

NVI:

CSOL:

TPRE:

MDL:

CGLO:

FAS:

DAM:

AGIF:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:	100142029(FGF-2) 103314033(FGF-1)

SOY:

115887984

AGRG:

126737033

ATD:	109598033 126266030

CSET:

123316491 123316492

HAXR:

123682288 123682289

AGB:

108913703

LDC:	111512809 111512810

DVV:

PPYR:

API:

DNX:

AGS:

RMD:

DVT:

CLEC:

HHAL:

NLU:

HVI:

PHU:	Phum_PHUM574560

FOC:

TPAL:

ZNE:

BROR:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

MRJ:

HAZT:

PPOI:

RSAN:

CSCU:

CVS:

LPOL:

OBI:

OSN:

NVE:	116612414 5508136

EPA:	110233856 110236145 110236147 110251784 110251813 110255019

ATEN:

116289049 116290097 116290101 116301931 116301947 116307011

ADF:	107336821 107338455 107338459 107338461 107348694 107348728

AMIL:

114950744 114960840 114961131 114969095

MCAZ:

138041636 138041645 138050763 138050771

MFOO:

137968103 137994439 137994440 137994441 137995214 138012777

PDAM:

113671877 113671878 113672023 113676841 113677021 113678664

SPIS:

111327643 111333596 111333597 111333604 111345914

DGT:

114526995

XEN:	124442239 124452753

HMG:	101238155 105846314

HSY:

130645444

RES:	135685250 135686813 135696132

» show all

Reference

PMID:2393407

Authors

Crumley G, Dionne CA, Jaye M

Title

The gene for human acidic fibroblast growth factor encodes two upstream exons alternatively spliced to the first coding exon.

Journal

Biochem Biophys Res Commun 171:7-13 (1990)
DOI:10.1016/0006-291X(90)91348-V

Sequence

[hsa:2246]

All links

Ontology (4)   
   KEGG BRITE (3)   
   GO (1)   
Pathway (22)   
   KEGG PATHWAY (22)   
Gene (764)   
   KEGG GENES (681)   
   KEGG MGENES (30)   
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Literature (1)   
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