KEGG ORTHOLOGY: K01946

ORTHOLOGY: K01946

Entry

K01946                      KO

Symbol

ACACB

Name

acetyl-CoA carboxylase / biotin carboxylase 2 [EC:6.4.1.2 6.3.4.14 2.1.3.15]

Pathway

map00061

Fatty acid biosynthesis

map00254

Aflatoxin biosynthesis

map00620

Pyruvate metabolism

map00640

Propanoate metabolism

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

map01120

Microbial metabolism in diverse environments

map04152

AMPK signaling pathway

map04910

Insulin signaling pathway

map04920

Adipocytokine signaling pathway

map04922

Glucagon signaling pathway

map04931

Insulin resistance

map04936

Alcoholic liver disease

Reaction

R00742

acetyl-CoA:carbon-dioxide ligase (ADP-forming)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09101 Carbohydrate metabolism
   00620 Pyruvate metabolism
    K01946  ACACB; acetyl-CoA carboxylase / biotin carboxylase 2
   00640 Propanoate metabolism
    K01946  ACACB; acetyl-CoA carboxylase / biotin carboxylase 2
  09103 Lipid metabolism
   00061 Fatty acid biosynthesis
    K01946  ACACB; acetyl-CoA carboxylase / biotin carboxylase 2
  09110 Biosynthesis of other secondary metabolites
   00254 Aflatoxin biosynthesis
    K01946  ACACB; acetyl-CoA carboxylase / biotin carboxylase 2
09130 Environmental Information Processing
  09132 Signal transduction
   04152 AMPK signaling pathway
    K01946  ACACB; acetyl-CoA carboxylase / biotin carboxylase 2
09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K01946  ACACB; acetyl-CoA carboxylase / biotin carboxylase 2
   04922 Glucagon signaling pathway
    K01946  ACACB; acetyl-CoA carboxylase / biotin carboxylase 2
   04920 Adipocytokine signaling pathway
    K01946  ACACB; acetyl-CoA carboxylase / biotin carboxylase 2
09160 Human Diseases
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K01946  ACACB; acetyl-CoA carboxylase / biotin carboxylase 2
   04931 Insulin resistance
    K01946  ACACB; acetyl-CoA carboxylase / biotin carboxylase 2
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.3  Carboxy- and carbamoyltransferases
    2.1.3.15  acetyl-CoA carboxytransferase
     K01946  ACACB; acetyl-CoA carboxylase / biotin carboxylase 2
6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.14  biotin carboxylase
     K01946  ACACB; acetyl-CoA carboxylase / biotin carboxylase 2
  6.4  Forming carbon-carbon bonds
   6.4.1  Ligases that form carbon-carbon bonds (only sub-subclass identified to date)
    6.4.1.2  acetyl-CoA carboxylase
     K01946  ACACB; acetyl-CoA carboxylase / biotin carboxylase 2

Other DBs

GO:	0003989 0004075

Genes

HSA:

32(ACACB)

PTR:	452219(ACACB)

PPS:	100985999(ACACB)

GGO:	101135848(ACACB)

PON:	100448476(ACACB)

PPYG:

129010841(ACACB)

NLE:	100606756(ACACB)

HMH:	116477970(ACACB)

SSYN:

129459628(ACACB)

MCC:	706909(ACACB)

MCF:	102116004(ACACB)

MTHB:

126931421

MNI:	105493456(ACACB)

CSAB:

103239081(ACACB)

CATY:

105573223(ACACB)

PANU:

101012644(ACACB)

TGE:	112635049(ACACB)

MLEU:

105534647

RRO:	104660172(ACACB)

RBB:	108534384(ACACB)

TFN:	117089443(ACACB)

PTEH:

111538813(ACACB)

CANG:

105508229(ACACB)

CJC:	100402980(ACACB)

SBQ:	101037726(ACACB)

CIMI:

108313154(ACACB)

ANAN:

105728642(ACACB)

CSYR:

103274926(ACACB)

MMUR:

105866938(ACACB)

LCAT:

123625896(ACACB)

PCOQ:

105815036(ACACB)

OGA:	100959432(ACACB)

MMU:	100705(Acacb)

MCAL:

110294922(Acacb)

MPAH:

110312771(Acacb)

RNO:	116719(Acacb)

MCOC:

116068218(Acacb)

ANU:	117698256(Acacb)

ASYL:

127673395(Acacb)

MUN:	110547269(Acacb)

CGE:	100753124(Acacb)

MAUA:

101823042(Acacb)

PROB:

127215967(Acacb)

PLEU:

114681306(Acacb)

MORG:

121446056(Acacb)

MFOT:

126487966

AAMP:

119824641(Acacb)

NGI:	103746695(Acacb)

HGL:	101717399(Acacb)

CPOC:

100728089(Acacb)

CCAN:

109690552(Acacb)

DORD:

105984210(Acacb)

DSP:	122102681(Acacb)

PLOP:

125349023(Acacb)

NCAR:

124990202

MMMA:

107154522(Acacb)

ITI:	101964513(Acacb)

OCU:

100339362

OPI:	101529798(ACACB)

TUP:	102480265(ACACB)

GVR:	103588162(ACACB)

CFA:	100685468(ACACB)

CLUD:

112676715(ACACB)

VVP:	112910485(ACACB)

VLG:	121475814(ACACB)

NPO:	129507647(ACACB)

AML:	100474644(ACACB)

UMR:	103678344(ACACB)

UAH:	113267083(ACACB)

UAR:	123788217(ACACB)

ELK:

111156399

LLV:

125081691

MPUF:

101681819(ACACB)

MNP:	132023261(ACACB)

MLK:	131811784(ACACB)

NVS:	122903326(ACACB)

ORO:	101365780(ACACB)

EJU:	114219120(ACACB)

ZCA:	113912480(ACACB)

MLX:	118018582(ACACB)

NSU:	110592557(ACACB)

LWW:	102737604(ACACB)

FCA:	101086680(ACACB)

PYU:	121010188(ACACB)

PCOO:

112870451(ACACB)

PBG:	122470345(ACACB)

PVIV:

125149329(ACACB)

LRUF:

124518440

LGF:	123588317(ACACB)

AJU:

106979653

PTG:	102963315(ACACB)

PPAD:

109277478(ACACB)

PUC:

125914050

PLEZ:

122203074(ACACB)

HHV:	120237339(ACACB)

BTA:	515338(ACACB)

BOM:	102275206(ACACB)

BIU:	109571092(ACACB)

BBUB:

102404793(ACACB)

BBIS:

104980082(ACACB)

CHX:	102178200(ACACB)

OAS:	101114816(ACACB)

BTAX:

128062624(ACACB)

CSUM:

138093530(ACACB)

ODA:	120871398(ACACB)

CCAD:

122422201

MREE:

136145611(ACACB)

OVR:	110146411(ACACB)

MBEZ:

129542700(ACACB)

SSC:	100154993(ACACB)

CFR:	102512242(ACACB)

CBAI:

105075668(ACACB)

CDK:	105105357(ACACB)

VPC:	102524937(ACACB)

BACU:

103020229(ACACB)

BMUS:

118906860

LVE:	103089998(ACACB)

OOR:	101272632(ACACB)

LALB:

132532397(ACACB)

DLE:	111162815(ACACB)

PCAD:

102992865(ACACB)

PSIU:

116765119(ACACB)

NASI:

112397285(ACACB)

ECB:	100066740(ACACB)

EPZ:	103551425(ACACB)

EAI:	106848074(ACACB)

MYB:	102239000(ACACB)

MYD:	102759463(ACACB)

MMYO:

118678332(ACACB)

MLF:	102439451(ACACB)

MDT:	132221987(ACACB)

MYUM:

138997582(ACACB)

PKL:	118725382(ACACB)

EFUS:

103286902(ACACB)

MNA:	107533881(ACACB)

DRO:	112310890(ACACB)

SHON:

118991210(ACACB)

AJM:	119057414(ACACB)

PDIC:

114509274(ACACB)

PHAS:

123822289(ACACB)

MMF:	118639830(ACACB)

PPAM:

129087286(ACACB)

HAI:	109386154(ACACB)

RFQ:	117017281(ACACB)

PALE:

102887451(ACACB)

PGIG:

120601871(ACACB)

PVP:	105303961(ACACB)

RAY:	107500131(ACACB)

MJV:	108399878(ACACB)

TOD:	119244882(ACACB)

SARA:

101546832(ACACB)

SFUM:

130023924(ACACB)

SETR:

126031109(ACACB)

LAV:	100657186(ACACB)

TMU:

101351597

ETF:	101664465(ACACB)

DNM:	101426352(ACACB)

GAS:	123256906(ACACB)

SHR:	100932425(ACACB)

AFZ:

127545590

PCW:	110222829(ACACB)

TVP:	118857445(ACACB)

PBRV:

138156520(ACACB)

OAA:	100076923(ACACB)

TACU:

119941953(ACACB)

GGA:	430557(ACACB)

PCOC:

116228545(ACACB)

MGP:	100539060(ACACB)

CJO:	107321488(ACACB)

TPAI:

128084701(ACACB)

LMUT:

125701541(ACACB)

NMEL:

110406566(ACACB)

APLA:

119718533(ACACB)

ACYG:

106031086(ACACB)

CATA:

118257611(ACACB)

AFUL:

116496348(ACACB)

TGU:	100222747(ACACB)

LSR:	110478192(ACACB)

SCAN:

103818295(ACACB)

PMOA:

120509538(ACACB)

OTC:	121338832(ACACB)

PRUF:

121364815(ACACB)

ATRC:

139598613(ACACB)

GFR:	102045244(ACACB)

FAB:	101819106(ACACB)

OMA:	130259538(ACACB)

PHI:	102104651(ACACB)

PMAJ:

107211484(ACACB)

CCAE:

111936444(ACACB)

CCW:	104688808(ACACB)

CBRC:

103616066(ACACB)

ACOE:

138119167(ACACB)

ETL:	114062660(ACACB)

ZAB:	102071196(ACACB)

ZLE:	135454500(ACACB)

ACHL:

103808394(ACACB)

SVG:	106852463(ACACB)

MMEA:

130580515(ACACB)

HRT:	120760756(ACACB)

SATI:

136368993(ACACB)

CCIC:

134051117(ACACB)

FPG:	101913090(ACACB)

FCH:	102057711(ACACB)

CCRI:

104164563(ACACB)

NNT:	104412559(ACACB)

SHAB:

115614467(ACACB)

ACUN:

113486251(ACACB)

TALA:

104361116(ACACB)

ACHC:

115346453(ACACB)

HALD:

104313361

HLE:	104840951(ACACB)

AGEN:

126041164

HHAR:

128146253(ACACB)

GCL:

127022704

LDI:	104352539(ACACB)

DPUB:

104308504(ACACB)

PPUS:

135188633(ACACB)

AVIT:

104279589(ACACB)

BRHI:

104495923

EGZ:	104123683(ACACB)

NNI:	104019168(ACACB)

PCRI:

104028157(ACACB)

PADL:

103925656(ACACB)

AFOR:

103902755(ACACB)

FGA:	104076869(ACACB)

GSTE:

104259302

CLV:	102094512(ACACB)

MUI:	104545440(ACACB)

PLET:

104628539(ACACB)

EHS:	104509803(ACACB)

CUCA:

104058883(ACACB)

BREG:

104637633

OHA:	104331924(ACACB)

CPEA:

104388037(ACACB)

CVF:	104282293(ACACB)

RTD:	128917225(ACACB)

CRID:

134522761(ACACB)

AAM:	106487455(ACACB)

AROW:

112963361(ACACB)

NPD:	112945200(ACACB)

TGT:	104573449(ACACB)

DNE:	112991862(ACACB)

SCAM:

104149382(ACACB)

ASN:	102388393(ACACB)

AMJ:	102565973(ACACB)

CPOO:

109312689(ACACB)

GGN:	109290535(ACACB)

PSS:	102461239(ACACB)

CMY:	102942822(ACACB)

CCAY:

125622905(ACACB)

DCC:	119843568(ACACB)

CPIC:

101941488(ACACB)

TST:	117888262(ACACB)

CABI:

116839462(ACACB)

MRV:	120386003(ACACB)

ACS:	100566852(acacb)

ASAO:

132780396

PVT:	110083411(ACACB)

SUND:

121916415(ACACB)

PBI:	103057144(ACACB)

PMUR:

107287268(ACACB)

CTIG:

120316750(ACACB)

PGUT:

117672279 132708916

APRI:

131185569(ACACB)

PTEX:

113448653(ACACB)

NSS:	113423907(ACACB)

VKO:	123028590(ACACB)

PMUA:

114581463(ACACB)

PRAF:

128400787(ACACB)

ZVI:	118094218(ACACB)

HCG:	128338024(ACACB)

GJA:	107112178(ACACB)

STOW:

125442513(ACACB)

EMC:	129341574(ACACB)

XLA:

108715603

XTR:	100192373(acacb)

NPR:	108790508(ACACB)

RTEM:

120938141(ACACB)

BBUF:

120988859(ACACB)

BGAR:

122924353(ACACB)

PWL:	138266226(ACACB)

MUO:	115481190(ACACB)

GSH:	117364775(ACACB)

DRE:	556236(acacb)

SRX:

SANH:

SGH:

CCAR:

CAUA:

113048915 113096061(acacb)

CGIB:

127957899 128013082

PTET:

122344977(acacb)

LROH:

127165045(acacb)

OMC:	131541304(acacb)

PPRM:

120469545(acacb)

RKG:	130097143(acacb)

MAMB:

125267209(acacb)

CIDE:

127512572

CERY:

137034149(acacb)

MASI:

127418333 127438260

TROS:

130565610(acacb)

TDW:	130419350(acacb)

MANU:

129439815(acacb)

PDAB:

135732580(acacb)

IPU:

108255442

IFU:	128625450(acacb)

PHYP:

113524973(acacb)

SMEO:

124380419(acacb)

TFD:

113656619

CGAR:

128509164(acacb)

NGRA:

132872757(acacb)

TRN:	134335076(acacb)

AMEX:

103026070(acacb)

CMAO:

118827132(acacb)

EEE:

113589900

CHAR:

105889968(acacb)

SPIL:

134088685(acacb)

TRU:	101077743(acacb)

TFS:	130525566(acacb)

TNG:	GSTEN00029540G001

LCO:	104921250(acacb)

NCC:	104945029(acacb)

TBEN:

117476000(acacb)

CGOB:

115012970(acacb)

PGEO:

117452707(acacb)

GACU:

117535765(acacb)

EMAC:

134873256(acacb)

ELY:	117252866(acacb)

EFO:	125889833(acacb)

PLEP:

121944662(acacb)

SLUC:

116056576(acacb)

ECRA:

117944549(acacb)

ESP:	116689793(acacb)

PFLV:

114555987(acacb)

GAT:	120830227(acacb)

AFB:	129100949(acacb)

CLUM:

117736297(acacb)

PSWI:

130197443(acacb)

CANA:

137805148(acacb)

CVE:	137866976(acacb)

MSAM:

119892400(acacb)

SCHU:

122876475(acacb)

CUD:	121510493(acacb)

SPUL:

138610362(acacb)

LMIX:

132974219(acacb)

ALAT:

119019207(acacb)

ASTR:

137592796(acacb)

MZE:	101477909(acacb)

ONL:	100711220(acacb)

OAU:	116332374(acacb)

OLA:	101171338(acacb)

OML:	112147886(acacb)

CSAI:

133450466(acacb)

XMA:	102217269(acacb)

XCO:	114154254(acacb)

XHE:	116729438(acacb)

PRET:

103470346(acacb)

PFOR:

103142895(acacb)

PLAI:

106944558(acacb)

PMEI:

106918451(acacb)

GAF:	122828188(acacb)

PPRL:

129371940(acacb)

CVG:

107100048

CTUL:

119786620(acacb)

GMU:	124877619(acacb)

NFU:	107393958(acacb)

KMR:	108234549(acacb)

ALIM:

106521707

NWH:	119413964(acacb)

AOCE:

111568287(acacb)

EJA:	138191731(acacb)

BFRE:

138627315(acacb)

MCEP:

125011855(acacb)

CSEM:

103397308

POV:	109638102(acacb)

SSEN:

122769173(acacb)

SSOE:

131464078(acacb)

HHIP:

117767659(acacb)

HSP:	118114652(acacb)

PPLT:

128437942(acacb)

SMAU:

118313697(acacb)

LCF:

108878118

SDU:	111228114(acacb)

SLAL:

111660366(acacb)

XGL:	120805566(acacb)

HCQ:	109510822(acacb)

SSCV:

125993760(acacb)

SBIA:

133499883(acacb)

PEE:	133399791(acacb)

PTAO:

133475403(acacb)

BPEC:

110156685(acacb)

ENY:	140347212(acacb)

MALB:

109956888(acacb)

BSPL:

114862068(acacb)

SJO:	128364143(acacb)

SSCO:

133979657(acacb)

GMH:	115553600(acacb)

SASA:

106580110(acacb) 106585658

STRU:

115164864 115199799(acacb)

OTW:	112248237 112263291(acacb)

OMY:	110525352 110535755

OGO:	124034566 124036038

ONE:	115111329 115139760

OKI:	109876227 109895658(acacb)

OKE:	118358057(acacb) 118392929

OMM:	135514354 135524912

OCLA:

139389766 139410680

SALP:

111957851 111974209

SNH:	120050553 120063072

CCLU:

121550183 121584521

ELS:	105014434(acacb)

OEP:	134015382(acacb)

SFM:	108932552(acacb)

PKI:	111854891(acacb)

AANG:

118237551(acacb)

AROT:

135264735(acacb)

CCOG:

133140417(acacb)

LOC:	102687665(acacb)

PSPA:

121307729

ARUT:

117426575 117428031

PSEX:

120540759(acacb)

LCM:	102353666(ACACB)

CMK:	103184024(acacb)

CPLA:

122562396

HOC:	132827054(acacb)

LERI:

129709189(acacb)

OLU:

OSTLU_11

OTA:	OT_ostta10g03450

BPG:	Bathy11g03860

MIS:	MICPUN_104872

MPP:	MICPUCDRAFT_16401

» show all

Reference

PMID:19190759

Authors

Castle JC, Hara Y, Raymond CK, Garrett-Engele P, Ohwaki K, Kan Z, Kusunoki J, Johnson JM

Title

ACC2 is expressed at high levels in human white adipose and has an isoform with a novel N-terminus [corrected].

Journal

PLoS One 4:e4369 (2009)
DOI:10.1371/journal.pone.0004369

Sequence

[hsa:32]

Reference

PMID:16854592

Authors

Cheng D, Chu CH, Chen L, Feder JN, Mintier GA, Wu Y, Cook JW, Harpel MR, Locke GA, An Y, Tamura JK

Title

Expression, purification, and characterization of human and rat acetyl coenzyme A carboxylase (ACC) isozymes.

Journal

Protein Expr Purif 51:11-21 (2007)
DOI:10.1016/j.pep.2006.06.005

Sequence

[hsa:32]

All links

Ontology (2)   
   GO (2)   
Gene (1179)   
   MGENES (502)   
   RefGene (673)   
   OC (4)   
All databases (1181)   

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