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KEGG   DRUG: Vanzacaftor, tezacaftor and deutivacaftor
Entry
D13024            Mixture   Drug                                   
Name
Vanzacaftor, tezacaftor and deutivacaftor;
Alyftrek (TN)
Component
(Vanzacaftor calcium [DR:D12719] | Vanzacaftor [DR:D12718]), Tezacaftor [DR:D11041], Deutivacaftor [DR:D11423]
Class
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
Remark
ATC code: R07AX33
Efficacy
CFTR potentiator
  Disease
Cystic fibrosis (CFTR F508del homozygous mutation) [DS:H00218]
Cystic fibrosis (another responsive mutation in CFTR) [DS:H00218]
Target
CFTR* [HSA_VAR:1080v1] [HSA:1080] [KO:K05031]
  Pathway
hsa02010  ABC transporters
hsa04530  Tight junction
hsa04971  Gastric acid secretion
hsa04972  Pancreatic secretion
hsa04976  Bile secretion
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R07 OTHER RESPIRATORY SYSTEM PRODUCTS
   R07A OTHER RESPIRATORY SYSTEM PRODUCTS
    R07AX Other respiratory system products
     R07AX33 Deutivacaftor, tezacaftor and vanzacaftor
      D13024  Vanzacaftor, tezacaftor and deutivacaftor
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   D13024  Vanzacaftor, tezacaftor and deutivacaftor
Target-based classification of drugs [BR:br08310]
 Transporters
  ABC transporters
   ABCC subfamily
    CFTR* [HSA_VAR:1080v1]
     D13024  Vanzacaftor, tezacaftor and deutivacaftor
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D13024
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D13024
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D13024
Pharmacogenomic biomarkers [br08341.html]
 Germline mutations in genetic disorder treatments
  D13024

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