| Entry |
|
|---|
| Name |
Paltusotine (USAN/INN) |
|---|
| Formula |
C27H22F2N4O
|
|---|
| Exact mass |
456.1762
|
|---|
| Mol weight |
456.49
|
|---|
| Structure |
|
|---|
| Class |
Hormonal agent
DG01588 Somatostatin receptor agonist
|
|---|
| Remark |
|
|---|
| Efficacy |
Antineoplastic, Somatostatin receptor agonist |
|---|
| Comment |
Treatment of acromegaly, carcinoid syndrome and neuroendocrine tumors
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04935 | Growth hormone synthesis, secretion and action |
|
|---|
| Interaction |
|
|---|
| Brite |
Drug groups [BR:br08330]
Hormonal agent
DG01588 Somatostatin receptor agonist
DG03248 Paltusotine
D12477 Paltusotine
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Somatostatin
SSTR2
D12477 Paltusotine (USAN/INN)
Drug groups [BR:br08330]
Hormonal agent
DG01588 Somatostatin receptor agonist
DG03248 Paltusotine
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 34
1 C8y C 9.6600 -16.3800
2 C8x C 9.6600 -17.7800
3 C8x C 10.8724 -18.4800
4 C8y C 12.0849 -17.7800
5 C8y C 12.0849 -16.3800
6 C8x C 10.8724 -15.6800
7 N5x N 13.2973 -18.4800
8 C8x C 14.5097 -17.7800
9 C8y C 14.5097 -16.3800
10 C8y C 13.2973 -15.6800
11 C8y C 15.7073 -15.6885
12 C8x C 16.8956 -16.3745
13 C8y C 18.1080 -15.6745
14 C8x C 18.1080 -14.2745
15 C8y C 16.9197 -13.5885
16 C8x C 15.7073 -14.2885
17 C8y C 8.4476 -15.6800
18 C8x C 8.4476 -14.2802
19 C8x C 7.2351 -13.5802
20 C8x C 6.0227 -14.2802
21 C8y C 6.0227 -15.6800
22 C8y C 7.2351 -16.3800
23 O1a O 7.2351 -17.7798
24 C3b C 4.8082 -16.3812
25 N3a N 3.5958 -17.0812
26 X F 19.3392 -16.3855
27 X F 16.9196 -12.1801
28 N1y N 13.2973 -14.2800
29 C1x C 14.5118 -13.5788
30 C1x C 14.5118 -12.1788
31 C1y C 13.2993 -11.4788
32 C1x C 12.0849 -12.1800
33 C1x C 12.0849 -13.5800
34 N1a N 13.2993 -10.0800
BOND 38
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 4 7 1
8 7 8 2
9 8 9 1
10 9 10 2
11 5 10 1
12 9 11 1
13 11 12 2
14 12 13 1
15 13 14 2
16 14 15 1
17 15 16 2
18 11 16 1
19 1 17 1
20 17 18 2
21 18 19 1
22 19 20 2
23 20 21 1
24 21 22 2
25 17 22 1
26 22 23 1
27 21 24 1
28 24 25 3
29 13 26 1
30 15 27 1
31 10 28 1
32 28 29 1
33 29 30 1
34 30 31 1
35 31 32 1
36 32 33 1
37 28 33 1
38 31 34 1
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