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KEGG   DRUG: Crinecerfont
Entry
D12366                      Drug                                   
Name
Crinecerfont (USAN);
Crenessity (TN)
Formula
C27H28ClFN2OS
Exact mass
482.1595
Mol weight
483.04
Structure
Efficacy
Corticotropin releasing hormone receptor 1 antagonist
  Disease
Congenital adrenal hyperplasia [DS:H00216]
Comment
Treatment of congenital adrenal hyperplasia
Target
CRHR1 [HSA:1394] [KO:K04578]
Brite
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Secretin receptor family
   Corticotropin-releasing hormone
    CRHR1
     D12366  Crinecerfont (USAN)
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D12366
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D12366
Other DBs
CAS: 752253-39-7
PubChem: 497620779
KCF data

ATOM        33
            1   C8y C    21.5933  -16.2637
            2   C8x C    21.5933  -17.6658
            3   C8y C    22.7851  -18.3668
            4   C8y C    24.0470  -17.6658
            5   C8x C    24.0470  -16.2637
            6   C8y C    22.7851  -15.5626
            7   O2a O    25.2388  -18.3668
            8   C1a C    26.4305  -17.6658
            9   C1a C    22.7851  -19.7689
            10  X   Cl   22.7851  -14.1605
            11  C8y C    20.4015  -15.5626
            12  C8y C    19.9108  -14.2306
            13  S2x S    18.5087  -14.2306
            14  C8y C    18.0881  -15.5626
            15  N5x N    19.2799  -16.4039
            16  C1c C    15.7045  -15.5626
            17  N1c N    16.8963  -16.2637
            18  C1b C    16.8963  -17.6658
            19  C1a C    20.6820  -13.1090
            20  C3b C    18.0881  -18.3668
            21  C3a C    19.3500  -19.0679
            22  C8y C    14.5127  -16.2637
            23  C1b C    15.7045  -14.1605
            24  C1y C    14.5127  -13.4595
            25  C8x C    13.3210  -15.5626
            26  C8y C    12.0591  -16.2637
            27  C8y C    12.0591  -17.6658
            28  C8x C    13.2508  -18.3668
            29  C8x C    14.5127  -17.6658
            30  X   F    10.8673  -15.5626
            31  C1a C    10.8673  -18.3668
            32  C1x C    13.1106  -13.4595
            33  C1x C    13.8117  -12.2677
BOND        36
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     3   9 1
            10    6  10 1
            11    1  11 1
            12   11  12 2
            13   12  13 1
            14   13  14 1
            15   14  15 2
            16   11  15 1
            17   16  17 1
            18   17  14 1
            19   17  18 1
            20   12  19 1
            21   18  20 1
            22   20  21 3
            23   16  22 1
            24   16  23 1 #Down
            25   23  24 1
            26   22  25 2
            27   25  26 1
            28   26  27 2
            29   27  28 1
            30   28  29 2
            31   22  29 1
            32   26  30 1
            33   27  31 1
            34   32  24 1
            35   24  33 1
            36   33  32 1

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Ontology (3)   
   KEGG BRITE (3)   
Disease (1)   
   KEGG DISEASE (1)   
Chemical substance (1)   
   PubChem (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
All databases (7)   

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