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KEGG   DRUG: Pozelimab
Entry
D11477                      Drug                                   
Name
Pozelimab (USAN);
Pozelimab-bbfg;
Veopoz (TN)
Product
Formula
C6418H9898N1690O2026S42
Exact mass
144405.1712
Mol weight
144494.17
Sequence
(Heqvy chain)
QVQLQESGPG LVKPSETLSL TCTVSGDSVS SSYWTWIRQP PGKGLEWIGY IYYSGSSNYN
PSLKSRATIS VDTSKNQFSL KLSSVTAADT AVYYCAREGN VDTTMIFDYW GQGTLVTVSS
ASTKGPSVFP LAPCSRSTSE STAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS
GLYSLSSVVT VPSSSLGTKT YTCNVDHKPS NTKVDKRVES KYGPPCPPCP APEFLGGPSV
FLFPPKPKDT LMISRTPEVT CVVVDVSQED PEVQFNWYVD GVEVHNAKTK PREEQFNSTY
RVVSVLTVLH QDWLNGKEYK CKVSNKGLPS SIEKTISKAK GQPREPQVYT LPPSQEEMTK
NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLYSRL TVDKSRWQEG
NVFSCSVMHE ALHNHYTQKS LSLSLG
(Light chain)
AIQMTQSPSS LSASVGDRVT ITCRASQGIR NDLGWYQQKP GKAPKLLIYA ASSLQSGVPS
RFAGRGSGTD FTLTISSLQP EDFATYYCLQ DFNYPWTFGQ GTKVEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide bridge: H22-H95, H134-L214, H147-H203, H226-H'226, H229-H'229, H261-H321, H367-H425, H'22-H'95, H'134-L'214, H'147-H'203, H'261-H'321, H'367-H'425, L23-L88, L134-L194, L'23-L'88, L'134-L'194)
  Type
Peptide
Remark
ATC code: L04AJ11
Product: D11477<US>
Efficacy
Anti-inflammatory, Anti-complement C5 antibody
  Disease
CD55-deficient protein-losing enteropathy [DS:H00106]
  Type
Monoclonal antibody
Comment
Treatment of paroxysmal nocturnal hemoglobinuria
Target
C5 [HSA:727] [KO:K03994]
  Pathway
hsa04610  Complement and coagulation cascades
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AJ Complement inhibitors
     L04AJ11 Pozelimab
      D11477  Pozelimab (USAN) <US>
USP drug classification [BR:br08302]
 Immunological Agents
  Immunological Agents, Other
   Complement Inhibitors
    Pozelimab
     D11477  Pozelimab (USAN)
Target-based classification of drugs [BR:br08310]
 Peptidases and inhibitors
  Peptidase inhibitors
   alpha2M family
    C5
     D11477  Pozelimab (USAN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11477
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11477
Other DBs
CAS: 2096328-94-6
PubChem: 384585453

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