[go: up one dir, main page]
More Web Proxy on the site http://driver.im/
KEGG   DRUG: Lumateperone tosylate
Entry
D11170                      Drug                                   
Name
Lumateperone tosylate (USAN);
Caplyta (TN)
Product
CAPLYTA (Intra-Cellular Therapies)
Formula
C24H28FN3O. C7H8O3S
Exact mass
565.2411
Mol weight
565.70
Structure
Remark
ATC code: N05AD10
Chemical structure group: DG02937
Product (DG02937): D11170<US>
Efficacy
Antipsychotic
  Disease
Schizophrenia [DS:H01649]
Bipolar I or II disorder [DS:H01653]
Comment
Treatment of schizophrenia, bipolar disorder and behavioral and sleep disturbances
Target
HTR2A [HSA:3356] [KO:K04157]
DRD2 [HSA:1813] [KO:K04145]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AD Butyrophenone derivatives
     N05AD10 Lumateperone
      D11170  Lumateperone tosylate (USAN) <US>
USP drug classification [BR:br08302]
 Antipsychotics
  2nd Generation/Atypical
   Lumateperone
    D11170  Lumateperone tosylate (USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD2
     D11170  Lumateperone tosylate (USAN) <US>
   Serotonin
    HTR2A
     D11170  Lumateperone tosylate (USAN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11170
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11170
Other DBs
CAS: 1187020-80-9
PubChem: 376219094
KCF data

ATOM        40
            1   C8x C     3.9844  -16.7214
            2   C8y C     3.9844  -18.1207
            3   C8x C     5.1739  -18.8204
            4   C8x C     6.4332  -18.1207
            5   C8y C     6.4332  -16.7214
            6   C8x C     5.1739  -16.0218
            7   C5a C     7.6226  -16.0218
            8   C1b C     8.8820  -16.7214
            9   C1b C    10.0714  -16.0218
            10  C1b C    11.2608  -16.7214
            11  N1y N    12.4502  -16.0218
            12  C1x C    13.7096  -16.7214
            13  C1y C    14.8990  -16.0218
            14  C1y C    14.8990  -14.6225
            15  C1x C    13.7096  -13.9228
            16  C1x C    12.4502  -14.6225
            17  X   F     2.7950  -18.8204
            18  O5a O     7.6226  -14.6225
            19  C8y C    16.2283  -16.4416
            20  C8y C    16.9979  -15.3221
            21  N1y N    16.2283  -14.2027
            22  C8y C    18.3972  -15.3221
            23  N1y N    19.0269  -14.1327
            24  C1x C    18.3272  -12.8734
            25  C1x C    16.9979  -12.8734
            26  C8x C    16.9280  -17.7709
            27  C8x C    18.3272  -17.7709
            28  C8x C    19.0269  -16.5815
            29  C1a C    20.3562  -13.9928
            30  C8x C    23.8700  -16.0300
            31  C8x C    23.8700  -17.4300
            32  C8y C    25.0824  -18.1300
            33  C8x C    26.2949  -17.4300
            34  C8x C    26.2949  -16.0300
            35  C8y C    25.0824  -15.3300
            36  C1a C    25.0824  -19.5298
            37  S4a S    25.0824  -13.9302
            38  O1d O    23.6824  -13.9302
            39  O1d O    26.4824  -13.9302
            40  O1d O    25.0824  -12.5302
BOND        44
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15   14  15 1
            16   15  16 1
            17   11  16 1
            18    2  17 1
            19    7  18 2
            20   13  19 1
            21   19  20 1
            22   20  21 1
            23   14  21 1
            24   20  22 2
            25   22  23 1
            26   23  24 1
            27   24  25 1
            28   21  25 1
            29   19  26 2
            30   26  27 1
            31   27  28 2
            32   28  22 1
            33   23  29 1
            34   30  31 2
            35   31  32 1
            36   32  33 2
            37   33  34 1
            38   34  35 2
            39   30  35 1
            40   32  36 1
            41   35  37 1
            42   37  38 2
            43   37  39 2
            44   37  40 1

» Japanese version   » Back

  All links  
Ontology (5)   
   KEGG BRITE (5)   
Disease (2)   
   KEGG DISEASE (2)   
Drug (1)   
   KEGG DGROUP (1)   
Chemical substance (1)   
   PubChem (1)   
Gene (4)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (2)   
All databases (13)   

Download RDF
DBGET integrated database retrieval system