[go: up one dir, main page]
More Web Proxy on the site http://driver.im/
KEGG   DRUG: Vonoprazan, amoxicillin and clarithromycin
Entry
D10775            Mixture   Drug                                   
Name
Vonoprazan, amoxicillin and clarithromycin;
Vonosap (TN);
Voquenza (TN)
Component
Vonoprazan fumarate [DR:D10466], (Amoxicillin hydrate [DR:D00229] | Amoxicillin [DR:D07452]), Clarithromycin [DR:D00276]
Class
Metabolizing enzyme substrate
 DG02919  CYP2B6 substrate
 DG01639  CYP2C19 substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Metabolizing enzyme inhibitor
 DG02852  CYP3A/CYP3A4 inhibitor
  DG01522  CYP3A4 inhibitor
Transporter inhibitor
 DG01622  ABCB1 inhibitor
Remark
Therapeutic category: 6199
ATC code: A02BD14
Product: D10775<JP>
Efficacy
Antibacterial
  Disease
Helicobacter pylori infection [DS:H00320]
Comment
Vonoprazan is metabolized by CYP3A4 with some contribution from CYP2B6, CYP2C19 and CYP2D6.
Clarithromycin is an inhibitor and a substrate of CYP3A4, and it is an inhibitor of P-gp.
Metabolism
Enzyme: CYP3A4 [HSA:1576]; CYP2B6 [HSA:1555], CYP2C19 [HSA:1557], CYP2D6 [HSA:1565]
Interaction
CYP inhibition: CYP3A4 [HSA:1576]
Transporter inhibition: ABCB1 [HSA:5243]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A02 DRUGS FOR ACID RELATED DISORDERS
   A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
    A02BD Combinations for eradication of Helicobacter pylori
     A02BD14 Vonoprazan, amoxicillin and clarithromycin
      D10775  Vonoprazan, amoxicillin and clarithromycin <JP>
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Gastrointestinal Agents, Other
   Amoxicillin/ Clarithromycin/ Vonoprazan
    D10775  Vonoprazan, amoxicillin and clarithromycin
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   619  Miscellaneous
    6199  Miscellaneous
     D10775  Vonoprazan, amoxicillin and clarithromycin
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG02919  CYP2B6 substrate
   D10775  Vonoprazan, amoxicillin and clarithromycin
  DG01639  CYP2C19 substrate
   D10775  Vonoprazan, amoxicillin and clarithromycin
  DG01644  CYP2D6 substrate
   D10775  Vonoprazan, amoxicillin and clarithromycin
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D10775  Vonoprazan, amoxicillin and clarithromycin
 Metabolizing enzyme inhibitor
  DG02852  CYP3A/CYP3A4 inhibitor
   DG01522  CYP3A4 inhibitor
    D10775  Vonoprazan, amoxicillin and clarithromycin
 Transporter inhibitor
  DG01622  ABCB1 inhibitor
   D10775  Vonoprazan, amoxicillin and clarithromycin
Antimicrobials [BR:br08307]
 Antibacterials
  Cell wall biosynthesis inhibitor, beta-lactam
   Combination for eradication of H. pylori
    D10775  Vonoprazan, amoxicillin and clarithromycin <JP>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D10775
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D10775
 Drug transporters
  D10775
Other DBs
PubChem: 313046633

» Japanese version   » Back

  All links  
Ontology (7)   
   KEGG BRITE (7)   
Disease (1)   
   KEGG DISEASE (1)   
Drug (6)   
   KEGG DGROUP (6)   
Chemical substance (1)   
   PubChem (1)   
All databases (15)   

Download RDF
DBGET integrated database retrieval system