[go: up one dir, main page]
More Web Proxy on the site http://driver.im/
KEGG   DRUG: Clopidogrel sulfate and aspirin
Entry
D10513            Mixture   Drug                                   
Name
Clopidogrel sulfate and aspirin;
Clopidogrel and acetylsalicyclic acid;
Complavin (TN)
Component
(Clopidogrel sulfate [DR:D00769] | Clopidogrel [DR:D07729]), Aspirin [DR:D00109]
Class
Metabolizing enzyme substrate
 DG01892  CYP1A2 substrate
 DG02919  CYP2B6 substrate
 DG01639  CYP2C19 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Metabolizing enzyme inhibitor
 DG01641  CYP2C8 inhibitor
Remark
Therapeutic category: 3399
ATC code: B01AC30
Product: D10513<JP>
Efficacy
Antiplatelet
Comment
Clopidogrel is metabolized to an active metabolite mainly by CYP2C19, and CYP1A2, CYP2B6 and CYP3A4 contribute to the generation of the active metabolite, and Clopidogrel glucuronate conjugate is an inhibitor of CYP2C8.
Metabolism
Enzyme: CYP2C19 [HSA:1557]; CYP1A2 [HSA:1544], CYP2B6 [HSA:1555], CYP3A4 [HSA:1576]
Interaction
CYP inhibition: CYP2C8 [HSA:1558]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B01 ANTITHROMBOTIC AGENTS
   B01A ANTITHROMBOTIC AGENTS
    B01AC Platelet aggregation inhibitors excl. heparin
     B01AC30 Combinations
      D10513  Clopidogrel sulfate and aspirin <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  33  Blood and body fluid agents
   339  Miscellaneous
    3399  Others
     D10513  Clopidogrel sulfate and aspirin
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   D10513  Clopidogrel sulfate and aspirin
  DG02919  CYP2B6 substrate
   D10513  Clopidogrel sulfate and aspirin
  DG01639  CYP2C19 substrate
   D10513  Clopidogrel sulfate and aspirin
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D10513  Clopidogrel sulfate and aspirin
 Metabolizing enzyme inhibitor
  DG01641  CYP2C8 inhibitor
   D10513  Clopidogrel sulfate and aspirin
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10513
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D10513
Other DBs
PubChem: 172232606

» Japanese version   » Back

  All links  
Ontology (5)   
   KEGG BRITE (5)   
Disease (1)   
   KEGG DISEASE (1)   
Drug (5)   
   KEGG DGROUP (5)   
Chemical substance (1)   
   PubChem (1)   
All databases (12)   

Download RDF
DBGET integrated database retrieval system