KEGG DRUG: Irbesartan and trichlormethiazide

DRUG: Irbesartan and trichlormethiazide

Entry

D10480            Mixture   Drug

Name

Irbesartan and trichlormethiazide;
Irtra (TN)

Component

Irbesartan [DR:D00523], Trichlormethiazide [DR:D00658]

Class

Cardiovascular agent
DG01925  Renin-angiotensin system inhibitor
DG03231  Antihypertensive
Metabolizing enzyme substrate
DG01642  CYP2C9 substrate
DG02924  UGT substrate

Remark

Therapeutic category:

2149

ATC code:

C09DA04

Product:

D10480<JP>

Efficacy

Antihypertensive

Comment

Irbesartan is metabolized via glucuronide conjugation and CYP2C9.

Metabolism

Enzyme: CYP2C9 [HSA:1559], UGT [KO:K00699]

Interaction

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
  C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
   C09D ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
    C09DA Angiotensin II receptor blockers (ARBs) and diuretics
     C09DA04 Irbesartan and diuretics
      D10480  Irbesartan and trichlormethiazide <JP>
Therapeutic category of drugs in Japan [BR:br08301]
2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D10480  Irbesartan and trichlormethiazide
Drug groups [BR:br08330]
Cardiovascular agent
  DG01925  Renin-angiotensin system inhibitor
   D10480  Irbesartan and trichlormethiazide
  DG03231  Antihypertensive
   D10480  Irbesartan and trichlormethiazide
Metabolizing enzyme substrate
  DG01642  CYP2C9 substrate
   D10480  Irbesartan and trichlormethiazide
  DG02924  UGT substrate
   D10480  Irbesartan and trichlormethiazide
Drug classes [BR:br08332]
Cardiovascular agent
  DG03231  Antihypertensive
   D10480  Irbesartan and trichlormethiazide
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D10480

Other DBs

PubChem:

172232573

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Ontology (5)   
   KEGG BRITE (5)   
Disease (1)   
   KEGG DISEASE (1)   
Drug (4)   
   KEGG DGROUP (4)   
Chemical substance (1)   
   PubChem (1)   
All databases (11)   

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