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KEGG   DRUG: Elosulfase alfa
Entry
D10333                      Drug                                   
Name
Elosulfase alfa (USAN);
Elosulfase alfa (genetical recombination) (JAN);
Vimizim (TN)
Product
VIMIZIM (BioMarin Pharmaceutical)
Formula
C5020H7572N1364O1420S32
Exact mass
110707.3291
Mol weight
110776.26
Sequence
APQPPNILLL LMDDMGWGDL GVYGEPSRET PNLDRMAAEG LLFPNFYSAN PLCSPSRAAL
LTGRLPIRNG FYTTNAHARN AYTPQEIVGG IPDSEQLLPE LLKKAGYVSK IVGKWHLGHR
PQFHPLKHGF DEWFGSPNCH FGPYDNKARP NIPVYRDWEM VGRYYEEFPI NLKTGEANLT
QIYLQEALDF IKRQARHHPF FLYWAVDATH APVYASKPFL GTSQRGRYGD AVREIDDSIG
KILELLQDLH VADNTFVFFT SDNGAALISA PEQGGSNGPF LCGKQTTFEG GMREPALAWW
PGHVTAGQVS HQLGSIMDLF TTSLALAGLT PPSDRAIDGL NLLPTLLQGR LMDRPIFYYR
GDTLMAATLG QHKAHFWTWT NSWENFRQGI DFCPGQNVSG VTTHNLEDHT KLPLIFHLGR
DPGERFPLSF ASAEYQEALS RITSVVQQHQ EALVPAQPQL NVCNWAVMNW APPGCEKLGK
CLTPPESIPK KCLWSH
(Disulfide bridge: 282-393, 282'-393', 463-492, 463'-492', 475-481, 475'-481')
  Type
Peptide
Remark
Therapeutic category: 3959
ATC code: A16AB12
Product: D10333<JP/US>
Efficacy
Lysosomal storage disease treatment, Enzyme replacement (N-acetylgalactosamine-6-sulfatase)
  Disease
Mucopolysaccharidosis type IVA [DS:H00123]
  Type
Enzyme replacement therapy product
Target
GALNS* [HSA_VAR:2588v1] [HSA:2588] [KO:K01132]
  Pathway
hsa00531  Glycosaminoglycan degradation
hsa04142  Lysosome
  Network
nt06012  Glycosaminoglycan degradation
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A16 OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
   A16A OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
    A16AB Enzymes
     A16AB12 Elosulfase alfa
      D10333  Elosulfase alfa (USAN) <JP/US>
USP drug classification [BR:br08302]
 Genetic, Enzyme, or Protein Disorder: Replacement, Modifiers, Treatment
  Elosulfase Alfa
   D10333  Elosulfase alfa (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   395  Enzyme preparations
    3959  Others
     D10333  Elosulfase alfa (USAN); Elosulfase alfa (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Sulfatases
    GALNS* [HSA_VAR:2588v1]
     D10333  Elosulfase alfa (USAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D10333
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10333
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10333
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10333
Pharmacogenomic biomarkers [br08341.html]
 Germline mutations in genetic disorder treatments
  D10333
Other DBs
CAS: 9025-60-9
PubChem: 172232427

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Ontology (9)   
   KEGG BRITE (9)   
Network (1)   
   KEGG VARIANT (1)   
Disease (1)   
   KEGG DISEASE (1)   
Chemical substance (1)   
   PubChem (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
All databases (14)   

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