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KEGG   DRUG: Amifampridine
Entry
D10228                      Drug                                   
Name
Amifampridine (USAN/INN);
Ruzurgi (TN)
Formula
C5H7N3
Exact mass
109.0640
Mol weight
109.13
Structure
Simcomp
Class
Metabolizing enzyme substrate
 DG02928  NAT substrate
Remark
ATC code: N07XX05
Chemical structure group: DG02003
Product (DG02003): D10689<JP/US>
Efficacy
Autoimmune disease treatment, Potassium channel blocker
  Disease
Lambert-Eaton myasthenic syndrome [DS:H01596]
Comment
Symptomatic treatment of Lambert-Eaton myasthenic syndrome (LEMS) in adults
Target
KCNA [HSA:3736 3737 3738 3739 3741 3742 3743 3744] [KO:K04874 K04875 K04876 K04877 K04878 K04879 K04880 K04881]
KCNB [HSA:3745 9312] [KO:K04885 K04886]
KCNC [HSA:3746 3747 3748 3749] [KO:K04887 K04888 K04889 K04890]
KCND [HSA:3750 3751 3752] [KO:K04891 K04892 K04893]
Metabolism
Enzyme: NAT [HSA:9 10]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07X OTHER NERVOUS SYSTEM DRUGS
    N07XX Other nervous system drugs
     N07XX05 Amifampridine
      D10228  Amifampridine (USAN/INN)
USP drug classification [BR:br08302]
 Central Nervous System Agents
  Central Nervous System, Other
   Amifampridine
    D10228  Amifampridine (USAN/INN)
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG02928  NAT substrate
   DG02003  Amifampridine
    D10228  Amifampridine
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Potassium channels
    KCNA
     D10228  Amifampridine (USAN/INN)
    KCNB
     D10228  Amifampridine (USAN/INN)
    KCNC
     D10228  Amifampridine (USAN/INN)
    KCND
     D10228  Amifampridine (USAN/INN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D10228
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG02928  NAT substrate
   DG02003  Amifampridine
Other DBs
CAS: 54-96-6
PubChem: 163312259
PDB-CCD: L89[PDBj]
KCF data

ATOM        8
            1   C8y C    11.0600  -18.8300
            2   C8x C    11.0600  -20.2300
            3   N5x N    12.2724  -20.9300
            4   C8x C    13.4849  -20.2300
            5   C8x C    13.4849  -18.8300
            6   C8y C    12.2724  -18.1300
            7   N1a N    12.2724  -16.7302
            8   N1a N     9.8476  -18.1300
BOND        8
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     6   7 1
            8     1   8 1

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