| Entry |
|
|---|
| Name |
Lesinurad sodium (USAN) |
|---|
| Formula |
C17H13BrN3O2S. Na
|
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| Exact mass |
424.9810
|
|---|
| Mol weight |
426.26
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Musculo-skeletal system agent
DG02042 Uricosurics
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
|
|---|
| Remark |
|
|---|
| Efficacy |
Gout suppressant, Uricosuric, Urate transporter inhibitor |
|---|
| Target |
|
|---|
| Metabolism |
Enzyme: CYP2C9 [HSA: 1559]
|
|---|
| Interaction |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
M MUSCULO-SKELETAL SYSTEM
M04 ANTIGOUT PREPARATIONS
M04A ANTIGOUT PREPARATIONS
M04AB Preparations increasing uric acid excretion
M04AB05 Lesinurad
D09922 Lesinurad sodium (USAN)
Drug groups [BR:br08330]
Musculo-skeletal system agent
DG02042 Uricosurics
DG01388 Lesinurad
D09922 Lesinurad sodium
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG01388 Lesinurad
D09922 Lesinurad sodium
Target-based classification of drugs [BR:br08310]
Transporters
Solute carrier family
SLC22
OAT4
D09922 Lesinurad sodium (USAN)
URAT1
D09922 Lesinurad sodium (USAN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D09922
Drug groups [BR:br08330]
Musculo-skeletal system agent
DG02042 Uricosurics
DG01388 Lesinurad
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG01388 Lesinurad
|
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| Other DBs |
|
|---|
| KCF data |
ATOM 25
1 C8x C 14.6980 -25.6865
2 C8x C 14.6980 -27.0864
3 C8y C 15.8879 -27.7863
4 C8y C 17.1477 -27.0864
5 C8y C 17.1477 -25.6865
6 C8y C 15.8879 -24.9866
7 C8x C 18.4075 -27.7863
8 C8x C 19.5974 -27.0864
9 C8x C 19.5974 -25.6865
10 C8x C 18.4075 -24.9866
11 N4y N 15.8879 -23.5868
12 C8y C 17.0077 -22.7469
13 N5x N 16.5878 -21.4871
14 N5x N 15.1880 -21.4871
15 C8y C 14.7680 -22.7469
16 S2a S 18.2675 -23.4468
17 C1b C 19.4574 -22.7469
18 C6a C 20.6472 -23.4468
19 O6a O 21.8371 -22.7469 #-
20 O6a O 20.6472 -24.8467
21 X Br 13.4382 -23.1669
22 C1y C 15.8879 -29.1861
23 C1x C 15.1880 -30.4459
24 C1x C 16.5878 -30.4459
25 Z Na 23.3769 -22.7469 #+
BOND 27
1 1 2 1
2 2 3 2
3 3 4 1
4 4 5 2
5 5 6 1
6 1 6 2
7 4 7 1
8 7 8 2
9 8 9 1
10 9 10 2
11 5 10 1
12 6 11 1
13 11 12 1
14 12 13 2
15 13 14 1
16 14 15 2
17 11 15 1
18 12 16 1
19 16 17 1
20 17 18 1
21 18 19 1
22 18 20 2
23 15 21 1
24 3 22 1
25 22 23 1
26 22 24 1
27 23 24 1
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