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KEGG   DRUG: Drospirenone and ethinylestradiol
Entry
D09741            Mixture   Drug                                   
Name
Drospirenone and ethinylestradiol;
Drospirenone and ethinylestradiol betadex;
Angeliq (TN);
Yaz (TN);
Flexyess (TN)
Product
YASMIN (Bayer HealthCare Pharmaceuticals), YAZ (Bayer HealthCare Pharmaceuticals)
  Generic
DROSPIRENONE AND ETHINYL ESTRADIOL (A-S Medication Solutions), DROSPIRENONE AND ETHINYL ESTRADIOL (A-S Medication Solutions), DROSPIRENONE AND ETHINYL ESTRADIOL (Camber Pharmaceuticals), DROSPIRENONE AND ETHINYL ESTRADIOL (Camber Pharmaceuticals), DROSPIRENONE AND ETHINYL ESTRADIOL (Glenmark Pharmaceuticals), DROSPIRENONE AND ETHINYL ESTRADIOL (Glenmark Pharmaceuticals), DROSPIRENONE AND ETHINYL ESTRADIOL (Lupin Pharmaceuticals), DROSPIRENONE AND ETHINYL ESTRADIOL (Mylan Pharmaceuticals), DROSPIRENONE AND ETHINYL ESTRADIOL (Mylan Pharmaceuticals), DROSPIRENONE AND ETHINYL ESTRADIOL (Naari Pte. Limited), DROSPIRENONE AND ETHINYL ESTRADIOL (Nivagen Pharmaceuticals), DROSPIRENONE AND ETHINYL ESTRADIOL (Nivagen Pharmaceuticals), DROSPIRENONE AND ETHINYL ESTRADIOL (Proficient Rx LP), DROSPIRENONE AND ETHINYL ESTRADIOL (RPK Pharmaceuticals), JASMIEL (Afaxys Pharma), JASMIEL (RPK Pharmaceuticals), LO-ZUMANDIMINE (Aurobindo Pharma Limited), LORYNA (Bryant Ranch Prepack), LORYNA (Xiromed), NIKKI (Lupin Pharmaceuticals), OCELLA (RPK Pharmaceuticals), OCELLA (TEVA PHARMACEUTICALS USA), SYEDA (Bryant Ranch Prepack), SYEDA (Xiromed), VESTURA (Teva Pharmaceuticals USA), VESTURA (Teva Pharmaceuticals), ZUMANDIMINE (Aurobindo Pharma Limited)
Component
Drospirenone [DR:D03917], (Ethinyl estradiol [DR:D00554] | Ethinylestradiol betadex)
Class
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 2482
ATC code: G03AA12
Product: D09741<JP/US>
Efficacy
Menstruation disorder agent
Comment
Drospirenone is a substrate of CYP3A4.
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
   G03A HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
    G03AA Progestogens and estrogens, fixed combinations
     G03AA12 Drospirenone and ethinylestradiol
      D09741  Drospirenone and ethinylestradiol <JP/US>
USP drug classification [BR:br08302]
 Contraceptives
  Oral Contraceptives Combinations
   Drospirenone/ Ethinyl Estradiol
    D09741  Drospirenone and ethinylestradiol
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   248  Mixed hormone preparations
    2482  Estrogens and progestins
     D09741  Drospirenone and ethinylestradiol
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D09741  Drospirenone and ethinylestradiol
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D09741
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D09741
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D09741
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D09741
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D09741
Other DBs
PubChem: 124490481

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