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KEGG   DRUG: Sotatercept
Entry
D09670                      Drug                                   
Name
Sotatercept (USAN/INN);
Sotatercept (genetical recombination) (JAN);
sotatercept-csrk;
Winrevair (TN)
Product
WINREVAIR (Merck Sharp & Dohme LLC)
Formula
C3448H5264N920O1058S42
Exact mass
77829.4657
Mol weight
77879.04
Sequence
ILGRSETQEC LFFNANWEKD RTNQTGVEPC YGDKDKRRHC FATWKNISGS IEIVKQGCWL
DDINCYDRTD CVEKKDSPEV YFCCCEGNMC NEKFSYFPEM EVTQPTSNPV TPKPPTGGGT
HTCPPCPAPE LLGGPSVFLF PPKPKDTLMI SRTPEVTCVV VDVSHEDPEV KFNWYVDGVE
VHNAKTKPRE EQYNSTYRVV SVLTVLHQDW LNGKEYKCKV SNKALPVPIE KTISKAKGQP
REPQVYTLPP SREEMTKNQV SLTCLVKGFY PSDIAVEWES NGQPENNYKT TPPVLDSDGS
FFLYSKLTVD KSRWQQGNVF SCSVMHEALH NHYTQKSLSL SPGK
(Disulfide bridge: 10-40, 30-58, 65-84, 71-83, 85-90, 158-218, 264-322, 123-123', 126-126')
  Type
Peptide
Remark
ATC code: C02KX06
Product: D09670<US>
Efficacy
Anti-anemic, Bone anabolic
  Disease
Pulmonary arterial hypertension [DS:H01621]
Comment
Fusion protein (extracellular domain of the activin receptor 2A and Fc of IgG1)
Red cell maturation agent for the treatment of anemia, and bone anabolic agent for the treatment of cancer-related bone loss
Target
ACVR2A [HSA:92] [KO:K04670]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04350  TGF-beta signaling pathway
hsa04550  Signaling pathways regulating pluripotency of stem cells
hsa05418  Fluid shear stress and atherosclerosis
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C02 ANTIHYPERTENSIVES
   C02K OTHER ANTIHYPERTENSIVES
    C02KX Antihypertensives for pulmonary arterial hypertension
     C02KX06 Sotatercept
      D09670  Sotatercept (USAN/INN) <US>
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Pulmonary Antihypertensives
   Activin A Receptor IIA Ligands
    Sotatercept
     D09670  Sotatercept (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor serine/threonine kinases (RSTK)
   TGFBR2 family
    ACVR2A
     D09670  Sotatercept (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D09670
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D09670
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D09670
Other DBs
CAS: 1001080-50-7
PubChem: 124490410

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Ontology (6)   
   KEGG BRITE (6)   
Disease (1)   
   KEGG DISEASE (1)   
Chemical substance (1)   
   PubChem (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
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