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KEGG   DRUG: Ustekinumab
Entry
D09214                      Drug                                   
Name
Ustekinumab (USAN/INN);
Ustekinumab (genetical recombination) (JAN);
Ustekinumab (genetical recombination) [Ustekinumab biosimilar 1] (JAN);
Ustekinumab (genetical recombination) [Ustekinumab biosimilar 2] (JAN);
Stelara (TN)
Product
STELARA (Janssen Biotech)
Formula
C6482H10004N1712O2016S46
Exact mass
145556.0075
Mol weight
145646.12
Class
Immunological agent
 DG02019  Interleukin inhibitor
Remark
Therapeutic category: 3999
ATC code: L04AC05
Product: D09214<JP/US>
Efficacy
Antipsoriatic, Anti-IL12/IL23 antibody
  Disease
Psoriasis [DS:H01656]
Psoriatic arthritis [DS:H01507]
Crohn's disease [DS:H00286]
Ulcerative colitis [DS:H01466]
  Type
Monoclonal antibody, bispecific antibody
Target
IL12 [HSA:3592 3593] [KO:K05406 K05425]
IL23A [HSA:51561] [KO:K05426]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  JAK-STAT signaling pathway
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AC Interleukin inhibitors
     L04AC05 Ustekinumab
      D09214  Ustekinumab (USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Immunological Agents
  Immunological Agents, Other
   Interleukin Blockers
    Ustekinumab
     D09214  Ustekinumab (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D09214  Ustekinumab (USAN/INN); Ustekinumab (genetical recombination) (JAN); Ustekinumab (genetical recombination) [Ustekinumab biosimilar 1] (JAN); Ustekinumab (genetical recombination) [Ustekinumab biosimilar 2] (JAN)
Drug groups [BR:br08330]
 Immunological agent
  DG02019  Interleukin inhibitor
   D09214  Ustekinumab
Drug classes [BR:br08332]
 Immunological agent
  DG02019  Interleukin inhibitor
   D09214  Ustekinumab
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   Interleukins
    IL12
     D09214  Ustekinumab (USAN/INN) <JP/US>
    IL23A
     D09214  Ustekinumab (USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D09214
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D09214
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D09214
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D09214
Other DBs
CAS: 815610-63-0
PubChem: 96025894

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