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KEGG   DRUG: Besifloxacin hydrochloride
Entry
D08872                      Drug                                   
Name
Besifloxacin hydrochloride (USAN);
Besivance (TN)
Product
BESIVANCE (A-S Medication Solutions), BESIVANCE (Bausch & Lomb Incorporated)
Formula
C19H21ClFN3O3. HCl
Exact mass
429.1022
Mol weight
430.30
Structure
Simcomp
Class
Antibacterial
 DG01550  Quinolone
  DG01549  Fluoroquinolone
Remark
ATC code: S01AE08
Product: D08872<US>
Efficacy
Antibacterial, Nucleic acid biosynthesis inhibitor
  Disease
Bacterial conjunctivitis [DS:H01366]
Comment
Fluoroquinolones
Target
DNA gyrase [KO:K02469 K02470]
topoisomerase IV [KO:K02621 K02622]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AE Fluoroquinolones
     S01AE08 Besifloxacin
      D08872  Besifloxacin hydrochloride (USAN) <US>
USP drug classification [BR:br08302]
 Ophthalmic Agents
  Ophthalmic Anti-Infectives
   Antibacterials, Ophthalmic
    Besifloxacin
     D08872  Besifloxacin hydrochloride (USAN)
Drug groups [BR:br08330]
 Antibacterial
  DG01550  Quinolone
   DG01549  Fluoroquinolone
    D08872  Besifloxacin hydrochloride
Drug classes [BR:br08332]
 Antibacterial
  DG01549  Fluoroquinolone
   D08872  Besifloxacin hydrochloride
Antimicrobials [BR:br08307]
 Antibacterials
  Nucleic acid synthesis inhibitor
   Fluoroquinolone
    D08872  Besifloxacin hydrochloride (USAN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D08872
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D08872
Other DBs
CAS: 405165-61-9
PubChem: 96025555
LigandBox: D08872
KCF data

ATOM        28
            1   C8y C    23.5900  -15.6100
            2   C8y C    23.5900  -17.0100
            3   C8y C    24.7800  -17.7100
            4   C8y C    26.0400  -17.0100
            5   C8y C    26.0400  -15.6100
            6   C8x C    24.7800  -14.9100
            7   N4y N    27.2300  -17.7100
            8   C8x C    28.4200  -17.0100
            9   C8y C    28.4200  -15.6100
            10  C8y C    27.2300  -14.9100
            11  X   F    22.4000  -14.9100
            12  O5x O    27.2300  -13.5100
            13  C6a C    29.6100  -14.9100
            14  O6a O    30.8000  -15.6100
            15  O6a O    29.6100  -13.5100
            16  C1y C    27.2300  -19.1100
            17  C1x C    27.9300  -20.3000
            18  C1x C    26.5300  -20.3000
            19  X   Cl   24.7628  -19.1099
            20  C1y C    20.1000  -18.3247
            21  C1x C    21.1967  -17.4610
            22  N1y N    22.5621  -17.7724
            23  C1x C    23.1640  -19.0256
            24  C1x C    20.1000  -19.7337
            25  C1x C    22.5630  -20.2929
            26  C1x C    21.1967  -20.6045
            27  N1a N    18.8385  -17.7124
            28  X   Cl   33.6000  -17.5000
BOND        30
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 2
            10    9  10 1
            11    5  10 1
            12    1  11 1
            13   10  12 2
            14    9  13 1
            15   13  14 1
            16   13  15 2
            17    7  16 1
            18   16  17 1
            19   16  18 1
            20   17  18 1
            21    3  19 1
            22   22  23 1
            23   20  24 1
            24   23  25 1
            25   21  22 1
            26   24  26 1
            27   20  21 1
            28   25  26 1
            29    2  22 1
            30   20  27 1 #Up

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Ontology (7)   
   KEGG BRITE (7)   
Disease (1)   
   KEGG DISEASE (1)   
Drug (2)   
   KEGG DGROUP (1)   
   LigandBox (1)   
Chemical substance (1)   
   PubChem (1)   
Gene (4)   
   KEGG ORTHOLOGY (4)   
All databases (15)   

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