| Entry |
|
|---|
| Name |
Ketoprofen sodium;
Orudis (TN) |
|---|
| Formula |
C16H13O3. Na
|
|---|
| Exact mass |
276.0762
|
|---|
| Mol weight |
276.26
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01908 Anti-inflammatory drug, propionic acid derivatives
Transporter inhibitor
DG02883 SLC22A7 inhibitor
|
|---|
| Remark |
| Product (DG00753): | D00132<JP/US> |
|
|---|
| Efficacy |
Analgesic, Anti-inflammatory, Antipyretic, COX inhibitor |
|---|
| Comment |
Propionic acid derivative
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Interaction |
Transporter inhibition: SLC22A7 [HSA: 10864]
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
M MUSCULO-SKELETAL SYSTEM
M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
M01AE Propionic acid derivatives
M01AE03 Ketoprofen
D08103 Ketoprofen sodium
M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
M02AA Antiinflammatory preparations, non-steroids for topical use
M02AA10 Ketoprofen
D08103 Ketoprofen sodium
Drug groups [BR:br08330]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01908 Anti-inflammatory drug, propionic acid derivatives
DG00753 Ketoprofen
D08103 Ketoprofen sodium
Transporter inhibitor
DG02883 SLC22A7 inhibitor
DG00753 Ketoprofen
D08103 Ketoprofen sodium
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Prostaglandin synthase
PTGS1 (COX1)
D08103 Ketoprofen sodium
PTGS2 (COX2)
D08103 Ketoprofen sodium
Drug metabolizing enzymes and transporters [br08309.html]
Drug transporters
D08103
Drug groups [BR:br08330]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01908 Anti-inflammatory drug, propionic acid derivatives
DG00753 Ketoprofen
Transporter inhibitor
DG02883 SLC22A7 inhibitor
DG00753 Ketoprofen
|
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| Other DBs |
|
|---|
| KCF data |
ATOM 20
1 C8x C 18.7600 -17.9200
2 C8x C 18.7600 -19.3200
3 C8x C 19.9500 -20.0200
4 C8x C 21.2100 -19.3200
5 C8y C 21.2100 -17.9200
6 C8x C 19.9500 -17.2200
7 C8x C 23.5900 -19.3200
8 C8y C 23.5900 -17.9200
9 C5a C 22.4000 -17.2200
10 C8x C 24.8500 -20.0200
11 C8x C 26.0400 -19.3200
12 C8y C 26.0400 -17.9200
13 C8x C 24.8500 -17.2200
14 O5a O 22.4000 -15.8200
15 C1c C 27.2300 -17.2200
16 C6a C 28.4200 -17.9200
17 C1a C 27.2300 -15.8200
18 O6a O 29.6100 -17.2200 #-
19 O6a O 28.4200 -19.3200
20 Z Na 32.6900 -17.9900 #+
BOND 20
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 7 8 1
8 8 9 1
9 5 9 1
10 7 10 2
11 10 11 1
12 11 12 2
13 12 13 1
14 8 13 2
15 9 14 2
16 12 15 1
17 15 16 1
18 15 17 1
19 16 18 1
20 16 19 2
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