| Entry |
|
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| Name |
Erythromycin stinoprate (INN);
Erysec (TN) |
|---|
| Formula |
C40H71NO14. C5H9NO3S
|
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| Exact mass |
952.5178
|
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| Mol weight |
953.19
|
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| Structure |
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| Simcomp |
|
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| Class |
Antibacterial
DG01551 Macrolide antibiotic
DG01874 14-membered ring macrolide antibiotic
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
Transporter inhibitor
DG01622 ABCB1 inhibitor
|
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| Remark |
| Product (DG00436): | D00140<JP/US> D01361<JP/US> D02009<JP/US> D02184<JP> |
|
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| Efficacy |
Antibacterial, Protein biosynthesis inhibitor |
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| Comment |
Active form of prodrug: Erythromycin [DR: D00140]
|
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| Target |
50S ribosomal subunit |
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| Pathway |
|
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| Metabolism |
|
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| Interaction |
CYP inhibition: CYP3A [HSA: 1576 1577 1551]
Transporter inhibition: ABCB1 [HSA: 5243]
|
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D10 ANTI-ACNE PREPARATIONS
D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
D10AF Antiinfectives for treatment of acne
D10AF02 Erythromycin
D07910 Erythromycin stinoprate (INN)
J ANTIINFECTIVES FOR SYSTEMIC USE
J01 ANTIBACTERIALS FOR SYSTEMIC USE
J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
J01FA Macrolides
J01FA01 Erythromycin
D07910 Erythromycin stinoprate (INN)
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01A ANTIINFECTIVES
S01AA Antibiotics
S01AA17 Erythromycin
D07910 Erythromycin stinoprate (INN)
Drug groups [BR:br08330]
Antibacterial
DG01551 Macrolide antibiotic
DG01874 14-membered ring macrolide antibiotic
DG00436 Erythromycin
D07910 Erythromycin stinoprate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG00436 Erythromycin
D07910 Erythromycin stinoprate
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG00436 Erythromycin
D07910 Erythromycin stinoprate
Transporter inhibitor
DG01622 ABCB1 inhibitor
DG00436 Erythromycin
D07910 Erythromycin stinoprate
Antimicrobials [BR:br08307]
Antibacterials
Protein biosynthesis inhibitor
Macrolide
D07910 Erythromycin stinoprate (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D07910
Drug transporters
D07910
Drug groups [BR:br08330]
Antibacterial
DG01551 Macrolide antibiotic
DG01874 14-membered ring macrolide antibiotic
DG00436 Erythromycin
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG00436 Erythromycin
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG00436 Erythromycin
Transporter inhibitor
DG01622 ABCB1 inhibitor
DG00436 Erythromycin
Antimicrobials abbreviations [BR:br08327]
Antibacterials
Protein biosynthesis inhibitor
Macrolide
DG00436 Erythromycin
|
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| Other DBs |
|
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| KCF data |
ATOM 65
1 C1y C 13.4813 -14.8764
2 C1z C 13.4813 -13.5435
3 C1y C 12.2887 -15.5780
4 O2a O 15.4456 -15.5780
5 C1x C 12.2887 -12.8420
6 O1a O 14.5336 -12.5613
7 C1a C 14.7441 -13.9644
8 C1y C 12.2887 -16.9109
9 C1a C 11.3066 -14.5256
10 C1y C 17.0592 -14.8764
11 C1y C 12.2887 -11.4389
12 O2a O 13.0604 -18.3139
13 C1y C 11.0961 -17.6124
14 C1y C 18.2518 -15.5780
15 O2x O 17.0592 -13.5435
16 C5x C 11.0961 -10.8075
17 C1a C 13.4813 -10.8075
18 C1y C 14.2536 -20.4849
19 C7x C 9.9035 -16.9109
20 C1a C 11.0961 -19.0155
21 C1y C 19.3041 -14.9466
22 O7a O 18.1816 -16.9810
23 C1y C 18.2518 -12.8420
24 C1y C 9.9035 -11.4389
25 O5x O 11.0961 -9.4044
26 C1x C 14.2536 -21.8178
27 O2x O 15.4462 -19.7833
28 O7x O 9.9035 -15.5780
29 O6a O 8.8512 -17.8930
30 C1x C 19.3742 -13.5435
31 N1c N 20.4967 -15.6481
32 C1a C 18.2518 -11.5090
33 C1y C 9.9035 -12.8420
34 C1a C 8.7810 -10.8075
35 C1z C 15.4462 -22.5193
36 C1y C 16.6389 -20.4849
37 C1y C 8.7810 -14.8764
38 C1z C 8.7810 -13.5435
39 O1a O 11.0961 -13.5435
40 C1y C 16.6389 -21.8178
41 O2a O 15.4462 -23.7821
42 C1a C 16.9195 -23.4313
43 C1a C 17.8315 -19.7833
44 C1b C 7.5884 -15.5780
45 C1a C 7.5183 -14.1047
46 O1a O 7.5183 -12.8420
47 O1a O 17.8315 -22.5193
48 C1a C 16.5687 -24.7642
49 C1a C 7.5884 -16.7004
50 C1a C 21.7595 -14.8764
51 C7a C 19.3839 -17.7572
52 O6a O 19.3839 -19.1572
53 C1a C 21.7416 -16.3458
54 C1b C 20.6084 -17.0904
55 C1a C 21.7776 -17.8050
56 C1b C 26.1791 -13.7540
57 C1c C 27.3942 -14.4555
58 S1a S 24.9641 -14.4555
59 C6a C 28.5923 -13.7636
60 O6a O 29.7823 -14.4506
61 O6a O 28.5924 -12.3512
62 N1b N 27.3943 -15.8584
63 C5a C 28.5925 -16.5503
64 C1a C 29.7822 -15.8634
65 O5a O 28.5926 -17.9629
BOND 66
1 1 2 1
2 1 3 1
3 1 4 1 #Down
4 2 5 1
5 2 6 1 #Up
6 2 7 1 #Down
7 3 8 1
8 3 9 1 #Down
9 10 4 1 #Down
10 5 11 1
11 8 12 1 #Down
12 8 13 1
13 10 14 1
14 10 15 1
15 11 16 1
16 11 17 1 #Down
17 18 12 1 #Down
18 13 19 1
19 13 20 1 #Up
20 14 21 1
21 14 22 1 #Up
22 15 23 1
23 16 24 1
24 16 25 2
25 18 26 1
26 18 27 1
27 19 28 1
28 19 29 2
29 21 30 1
30 21 31 1 #Down
31 23 32 1 #Down
32 24 33 1
33 24 34 1 #Up
34 26 35 1
35 27 36 1
36 28 37 1
37 33 38 1
38 33 39 1 #Up
39 35 40 1
40 35 41 1 #Down
41 35 42 1
42 36 43 1 #Up
43 37 44 1 #Down
44 38 45 1 #Down
45 38 46 1 #Up
46 40 47 1 #Down
47 41 48 1
48 44 49 1
49 23 30 1
50 36 40 1
51 37 38 1
52 31 50 1
53 22 51 1
54 51 52 2
55 31 53 1
56 51 54 1
57 54 55 1
58 56 57 1
59 56 58 1
60 57 59 1
61 59 60 1
62 59 61 2
63 57 62 1 #Up
64 62 63 1
65 63 64 1
66 63 65 2
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