| Entry |
|
|---|
| Name |
Cloranolol (INN) |
|---|
| Formula |
C13H19Cl2NO2
|
|---|
| Exact mass |
291.0793
|
|---|
| Mol weight |
292.20
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
DG01653 Antiarrhythmics
DG01806 Class II antiarrhythmic agent
|
|---|
| Remark |
|
|---|
| Efficacy |
beta-Adrenergic receptor antagonist |
|---|
| Comment |
Propranolol derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C07 BETA BLOCKING AGENTS
C07A BETA BLOCKING AGENTS
C07AA Beta blocking agents, non-selective
C07AA27 Cloranolol
D07183 Cloranolol (INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
D07183 Cloranolol
DG01653 Antiarrhythmics
DG01806 Class II antiarrhythmic agent
D07183 Cloranolol
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRB
D07183 Cloranolol (INN)
|
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| Other DBs |
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|---|
| KCF data |
ATOM 18
1 O2a O 16.8000 -17.5700
2 C1b C 18.0600 -16.8700
3 C1c C 19.2500 -17.5700
4 C1b C 20.4400 -16.8700
5 N1b N 21.6300 -17.5700
6 C1d C 22.8900 -16.8700
7 O1a O 19.2500 -18.9700
8 C1a C 24.0907 -17.5899
9 C1a C 22.9131 -15.4702
10 C1a C 24.1024 -16.1700
11 C8y C 16.7828 -18.9699
12 C8y C 15.5749 -19.6476
13 C8x C 15.5578 -21.0475
14 C8x C 16.7616 -21.7623
15 C8y C 17.9694 -21.0846
16 C8x C 17.9865 -19.6847
17 X Cl 14.3558 -18.9232
18 X Cl 19.1817 -21.8047
BOND 18
1 1 2 1
2 2 3 1
3 3 4 1
4 4 5 1
5 5 6 1
6 3 7 1
7 6 8 1
8 6 9 1
9 6 10 1
10 1 11 1
11 11 12 2
12 12 13 1
13 13 14 2
14 14 15 1
15 15 16 2
16 11 16 1
17 12 17 1
18 15 18 1
|
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