| Entry |
|
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| Name |
Pilocarpine nitrate (USP);
Pilagan (TN) |
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| Formula |
C11H16N2O2. HNO3
|
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| Exact mass |
271.1168
|
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| Mol weight |
271.27
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Neuropsychiatric agent
DG01490 Muscarinic cholinergic receptor agonist
DG01719 Parasympathomimetic agent
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
Metabolizing enzyme substrate
DG01638 CYP2A6 substrate
|
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| Remark |
| Product (DG00992): | D02200<JP/US> |
|
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| Efficacy |
Miotic, Muscarinic acetylcholine receptor agonist |
|---|
| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Metabolism |
Enzyme: CYP2A6 [HSA: 1548]
|
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| Interaction |
|
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| Structure map |
| map07220 | Cholinergic and anticholinergic drugs |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N07 OTHER NERVOUS SYSTEM DRUGS
N07A PARASYMPATHOMIMETICS
N07AX Other parasympathomimetics
N07AX01 Pilocarpine
D05478 Pilocarpine nitrate (USP)
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
S01EB Parasympathomimetics
S01EB01 Pilocarpine
D05478 Pilocarpine nitrate (USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01490 Muscarinic cholinergic receptor agonist
DG00992 Pilocarpine
D05478 Pilocarpine nitrate
DG01719 Parasympathomimetic agent
DG00992 Pilocarpine
D05478 Pilocarpine nitrate
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
DG00992 Pilocarpine
D05478 Pilocarpine nitrate
Metabolizing enzyme substrate
DG01638 CYP2A6 substrate
DG00992 Pilocarpine
D05478 Pilocarpine nitrate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Acetylcholine (muscarinic)
CHRM2
D05478 Pilocarpine nitrate (USP)
CHRM3
D05478 Pilocarpine nitrate (USP)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D05478
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01490 Muscarinic cholinergic receptor agonist
DG00992 Pilocarpine
DG01719 Parasympathomimetic agent
DG00992 Pilocarpine
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
DG00992 Pilocarpine
Metabolizing enzyme substrate
DG01638 CYP2A6 substrate
DG00992 Pilocarpine
|
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| Other DBs |
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| KCF data |
ATOM 19
1 C1y C 28.6049 -17.6741
2 C1y C 27.1960 -17.6741
3 C1b C 29.8268 -18.3174
4 C1x C 29.0492 -16.3294
5 C7x C 26.7576 -16.3294
6 C1b C 26.3656 -18.8143
7 C8y C 30.8967 -17.6799
8 O7x O 27.9034 -15.4992
9 O6a O 25.4128 -15.8909
10 C1a C 24.9625 -18.8082
11 N4y N 32.3115 -17.6799
12 C8x C 30.4524 -16.3353
13 C8x C 32.7443 -16.3353
14 C1a C 33.1359 -18.8200
15 N5x N 31.6043 -15.5050
16 N2b N 37.8531 -17.0458 #+
17 O3a O 37.8472 -15.6499
18 O3a O 39.0961 -17.7559 #-
19 O1b O 36.6419 -17.7522
BOND 19
1 1 2 1
2 1 3 1 #Down
3 1 4 1
4 2 5 1
5 2 6 1 #Down
6 3 7 1
7 4 8 1
8 5 9 2
9 6 10 1
10 7 11 1
11 7 12 2
12 11 13 1
13 11 14 1
14 12 15 1
15 5 8 1
16 13 15 2
17 16 17 2
18 16 18 1
19 16 19 1
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