| Entry |
|
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| Name |
Formoterol fumarate hydrate (JP18);
Formoterol fumarate dihydrate;
Atock (TN);
Foradil (TN) |
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| Product |
|
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| Generic |
|
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| Formula |
(C19H24N2O4)2. C4H4O4. 2H2O
|
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| Exact mass |
840.3793
|
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| Mol weight |
840.91
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Cardiovascular agent
DG01456 Adrenergic receptor agonist
DG01455 beta-Adrenergic receptor agonist
DG01452 beta2-Adrenergic receptor agonist
Metabolizing enzyme substrate
DG02924 UGT substrate
|
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| Remark |
| Therapeutic category: | 2259 |
| Product (DG01052): | D01373<US> D05277<JP/US> |
| Product (mixture): | D09595<JP/US> D10295<US> D10506<JP> D11036<JP/US> D11584<JP/US> |
|
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| Efficacy |
Bronchodilator, beta2-Adrenergic receptor agonist |
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| Disease |
Chronic obstructive pulmonary disease [DS: H01714] |
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| Comment |
Phenethylamine derivative
|
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| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Metabolism |
|
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| Interaction |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
R03A ADRENERGICS, INHALANTS
R03AC Selective beta-2-adrenoreceptor agonists
R03AC13 Formoterol
D05277 Formoterol fumarate hydrate (JP18) <JP/US>
R03C ADRENERGICS FOR SYSTEMIC USE
R03CC Selective beta-2-adrenoreceptor agonists
R03CC15 Formoterol
D05277 Formoterol fumarate hydrate (JP18) <JP/US>
USP drug classification [BR:br08302]
Respiratory Tract/Pulmonary Agents
Bronchodilators, Sympathomimetic
Formoterol
D05277 Formoterol fumarate hydrate (JP18)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
22 Respiratory organ agents
225 Bronchodilators
2259 Others
D05277 Formoterol fumarate hydrate (JP18)
Drug groups [BR:br08330]
Cardiovascular agent
DG01456 Adrenergic receptor agonist
DG01455 beta-Adrenergic receptor agonist
DG01452 beta2-Adrenergic receptor agonist
DG01052 Formoterol
D05277 Formoterol fumarate hydrate
Metabolizing enzyme substrate
DG02924 UGT substrate
DG01052 Formoterol
D05277 Formoterol fumarate hydrate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRB2
D05277 Formoterol fumarate hydrate (JP18) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D05277 Formoterol fumarate hydrate
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D05277
Drug groups [BR:br08330]
Cardiovascular agent
DG01456 Adrenergic receptor agonist
DG01455 beta-Adrenergic receptor agonist
DG01452 beta2-Adrenergic receptor agonist
DG01052 Formoterol
Metabolizing enzyme substrate
DG02924 UGT substrate
DG01052 Formoterol
|
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| Other DBs |
|
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| KCF data |
ATOM 60
1 O0 O 46.7600 -20.0900
2 C6a C 38.0100 -20.8600
3 C2b C 39.2000 -21.5600
4 O6a O 36.7500 -21.5600
5 O6a O 38.0100 -19.4600
6 C2b C 40.3900 -20.8600
7 C6a C 41.5800 -21.5600
8 O6a O 42.8400 -20.8600
9 O6a O 41.5800 -22.8900
10 C8y C 20.0200 -21.5600
11 C8x C 18.8300 -22.2600
12 C8x C 20.0200 -20.1600
13 C1c C 21.2100 -22.2600
14 C8y C 17.5700 -21.5600
15 C8x C 18.8300 -19.4600
16 C1b C 22.4700 -21.5600
17 O1a O 21.2100 -23.6600
18 C8y C 17.5700 -20.1600
19 N1b N 16.3800 -22.2600
20 N1b N 23.6600 -22.2600
21 O1a O 16.3800 -19.4600
22 C4a C 15.1900 -21.5600
23 C1c C 24.8500 -21.5600
24 O4a O 13.9300 -22.2600
25 C1b C 26.0400 -22.2600
26 C1a C 24.8500 -20.1600
27 C8y C 27.3000 -21.5600
28 C8x C 27.3000 -20.1600
29 C8x C 28.4900 -22.2600
30 C8x C 28.4900 -19.4600
31 C8x C 29.6800 -21.5600
32 C8y C 29.6800 -20.1600
33 O2a O 30.9400 -19.3900
34 C1a C 32.1300 -20.0900
35 O0 O 46.6900 -21.9100
36 C8y C 20.0200 -21.5600
37 C8x C 18.8300 -22.2600
38 C8y C 17.5700 -21.5600
39 C8y C 17.5700 -20.1600
40 O1a O 16.3800 -19.4600
41 C8x C 18.8300 -19.4600
42 C8x C 20.0200 -20.1600
43 N1b N 16.3800 -22.2600
44 C4a C 15.1900 -21.5600
45 O4a O 13.9300 -22.2600
46 C1c C 21.2100 -22.2600
47 C1b C 22.4700 -21.5600
48 N1b N 23.6600 -22.2600
49 C1c C 24.8500 -21.5600
50 C1b C 26.0400 -22.2600
51 C8y C 27.3000 -21.5600
52 C8x C 27.3000 -20.1600
53 C8x C 28.4900 -19.4600
54 C8y C 29.6800 -20.1600
55 O2a O 30.9400 -19.3900
56 C1a C 32.1300 -20.0900
57 C8x C 29.6800 -21.5600
58 C8x C 28.4900 -22.2600
59 C1a C 24.8500 -20.1600
60 O1a O 21.2100 -23.6600
BOND 59
1 2 3 1
2 2 4 1
3 2 5 2
4 3 6 2
5 6 7 1
6 7 8 1
7 7 9 2
8 10 11 2
9 10 12 1
10 10 13 1
11 11 14 1
12 12 15 2
13 13 16 1
14 13 17 1
15 14 18 2
16 14 19 1
17 16 20 1
18 18 21 1
19 19 22 1
20 20 23 1
21 22 24 2
22 23 25 1
23 23 26 1
24 25 27 1
25 27 28 2
26 27 29 1
27 28 30 1
28 29 31 2
29 30 32 2
30 32 33 1
31 33 34 1
32 15 18 1
33 31 32 1
34 36 37 2
35 36 42 1
36 36 46 1
37 37 38 1
38 42 41 2
39 46 47 1
40 46 60 1
41 38 39 2
42 38 43 1
43 47 48 1
44 39 40 1
45 43 44 1
46 48 49 1
47 44 45 2
48 49 50 1
49 49 59 1
50 50 51 1
51 51 52 2
52 51 58 1
53 52 53 1
54 58 57 2
55 53 54 2
56 54 55 1
57 55 56 1
58 41 39 1
59 57 54 1
BRACKET 1 12.7400 -24.3600 12.7400 -17.9900
1 34.3000 -17.9900 34.3000 -24.3600
1 2
ORIGINAL 1 10 11 14 18 21 15 12 19 22 24 13 16 20 23 25 27
1 28 30 32 33 34 31 29 26 17
REPEAT 1 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51
1 52 53 54 55 56 57 58 59 60
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