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KEGG   DRUG: Norgestrel and ethinylestradiol tablets
Entry
D04463            Mixture   Drug                                   
Name
Norgestrel and ethinylestradiol tablets (JP18);
Low-ogestrel (TN);
Planovar (TN)
Product
  Generic
CRYSELLE (A-S Medication Solutions), CRYSELLE (Preferred Pharmaceuticals), CRYSELLE (Proficient Rx LP), CRYSELLE (RPK Pharmaceuticals), CRYSELLE (Teva Pharmaceuticals USA), ELINEST (Northstar Rx LLC), LOW-OGESTREL (Dr. Reddy's Laboratories), LOW-OGESTREL (Mayne Pharma), LOW-OGESTREL (RPK Pharmaceuticals), TURQOZ (Lupin Pharmaceuticals)
Component
Norgestrel [DR:D00954], Ethinylestradiol [DR:D00554]
Class
Metabolizing enzyme substrate
 DG01642  CYP2C9 substrate
 DG01639  CYP2C19 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 2482
ATC code: G03AA06 G03FA10 G03FB01
Product: D04463<JP/US>
Efficacy
Contraceptive, Menstruation disorder agent
Comment
Combination of estrogen and progestin
Ethinylestradiol is a substrate for CYP3A4, CYP2C9 and CYP2C19.
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP2C9 [HSA:1559], CYP2C19 [HSA:1557]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
   G03A HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
    G03AA Progestogens and estrogens, fixed combinations
     G03AA06 Norgestrel and ethinylestradiol
      D04463  Norgestrel and ethinylestradiol tablets (JP18) <JP/US>
   G03F PROGESTOGENS AND ESTROGENS IN COMBINATION
    G03FA Progestogens and estrogens, fixed combinations
     G03FA10 Norgestrel and estrogen
      D04463  Norgestrel and ethinylestradiol tablets (JP18) <JP/US>
    G03FB Progestogens and estrogens, sequential preparations
     G03FB01 Norgestrel and estrogen
      D04463  Norgestrel and ethinylestradiol tablets (JP18) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   248  Mixed hormone preparations
    2482  Estrogens and progestins
     D04463  Norgestrel and ethinylestradiol tablets (JP18)
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01642  CYP2C9 substrate
   D04463  Norgestrel and ethinylestradiol tablets
  DG01639  CYP2C19 substrate
   D04463  Norgestrel and ethinylestradiol tablets
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D04463  Norgestrel and ethinylestradiol tablets
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D04463  Norgestrel and ethinylestradiol tablets
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D04463
Other DBs
PubChem: 17398116

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