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KEGG   DRUG: Pregabalin
Entry
D02716                      Drug                                   
Name
Pregabalin (JAN/USAN/INN);
Lyrica (TN)
Product
LYRICA (Aphena Pharma Solutions - Tennessee), LYRICA (Aphena Pharma Solutions - Tennessee), LYRICA (Parke-Davis Div of Pfizer), LYRICA (Viatris Specialty LLC), LYRICA CR (Parke-Davis Div of Pfizer), LYRICA CR (Viatris Specialty LLC)
  Generic
PREGABALIN (A-S Medication Solutions), PREGABALIN (A-S Medication Solutions), PREGABALIN (A-S Medication Solutions), PREGABALIN (A-S Medication Solutions), PREGABALIN (A-S Medication Solutions), PREGABALIN (A-S Medication Solutions), PREGABALIN (ADVANCED RX PHARMACY OF TENNESSEE), PREGABALIN (Actavis Pharma), PREGABALIN (Advagen Pharma), PREGABALIN (Advanced Rx Pharmacy of Tennessee), PREGABALIN (Advanced Rx Pharmacy of Tennessee), PREGABALIN (Advanced Rx Pharmacy of Tennessee), PREGABALIN (Advanced Rx Pharmacy of Tennessee), PREGABALIN (Advanced Rx Pharmacy of Tennessee), PREGABALIN (Advanced Rx Pharmacy of Tennessee), PREGABALIN (Advanced Rx Pharmacy of Tennessee), PREGABALIN (Advanced Rx Pharmacy of Tennessee), PREGABALIN (Advanced Rx Pharmacy of Tennessee), PREGABALIN (Advanced Rx Pharmacy of Tennessee), PREGABALIN (Advanced Rx Pharmacy of Tennessee), PREGABALIN (Advanced Rx Pharmacy of Tennessee), PREGABALIN (Advanced Rx Pharmacy of Tennessee), PREGABALIN (Advanced Rx Pharmacy of Tennessee), PREGABALIN (Advanced Rx Pharmacy of Tennessee), PREGABALIN (Advanced Rx Pharmacy of Tennessee), PREGABALIN (Advanced Rx Pharmacy of Tennessee), PREGABALIN (Advanced Rx Pharmacy of Tennessee), PREGABALIN (Advanced Rx Pharmacy of Tennessee), PREGABALIN (Advanced Rx Pharmacy of Tennessee), PREGABALIN (Advanced Rx Pharmacy of Tennessee), PREGABALIN (Advanced Rx of Tennessee), PREGABALIN (Alembic Pharmaceuticals Limited), PREGABALIN (Alembic Pharmaceuticals), PREGABALIN (American Health Packaging), PREGABALIN (Amneal Pharmaceuticals NY LLC), PREGABALIN (Amneal Pharmaceuticals NY LLC), PREGABALIN (Aphena Pharma Solutions - Tennessee), PREGABALIN (Aphena Pharma Solutions - Tennessee), PREGABALIN (Aphena Pharma Solutions - Tennessee), PREGABALIN (Aphena Pharma Solutions - Tennessee), PREGABALIN (Aphena Pharma Solutions - Tennessee), PREGABALIN (Aphena Pharma Solutions - Tennessee), PREGABALIN (Aphena Pharma Solutions - Tennessee), PREGABALIN (Aphena Pharma Solutions - Tennessee), PREGABALIN (Aphena Pharma Solutions - Tennessee), PREGABALIN (Aphena Pharma Solutions - Tennessee), PREGABALIN (Aphena Pharma Solutions - Tennessee), PREGABALIN (Aphena Pharma Solutions - Tennessee), PREGABALIN (Aphena Pharma Solutions - Tennessee), PREGABALIN (Aphena Pharma Solutions - Tennessee), PREGABALIN (Aphena Pharma Solutions - Tennessee), PREGABALIN (Aphena Pharma Solutions - Tennessee), PREGABALIN (Aphena Pharma Solutions - Tennessee), PREGABALIN (Aphena Pharma Solutions - Tennessee), PREGABALIN (Aphena Pharma Solutions - Tennessee), PREGABALIN (ApotexCorp), PREGABALIN (Ascend Laboratories), PREGABALIN (Ascend Laboratories), PREGABALIN (Asclemed USA), PREGABALIN (Asclemed USA), PREGABALIN (Asclemed USA), PREGABALIN (Asclemed USA), PREGABALIN (Aurobindo Pharma Limited), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Cadila Pharmaceuticals Limited), PREGABALIN (Camber Pharmaceuticals), PREGABALIN (Cardinal Health 107), PREGABALIN (Chartwell RX), PREGABALIN (Cipla USA), PREGABALIN (Creekwood Pharmaceuticals LLC), PREGABALIN (Direct Rx), PREGABALIN (Direct_Rx), PREGABALIN (Direct_Rx), PREGABALIN (Direct_Rx), PREGABALIN (Direct_Rx), PREGABALIN (Direct_Rx), PREGABALIN (Dr.Reddys Laboratories), PREGABALIN (Eskayef Pharmaceuticals Limited), PREGABALIN (Exelan Pharmaceuticals), PREGABALIN (Golden State Medical Supply), PREGABALIN (Greenstone LLC), PREGABALIN (Indoco Remedies Limited), PREGABALIN (MARKSANS PHARMA LIMITED), PREGABALIN (MSN LABORATORIES PRIVATE LIMITED), PREGABALIN (MSN LABORATORIES PRIVATE LIMITED), PREGABALIN (Major Pharmaceuticals), PREGABALIN (Medsource Pharmaceuticals), PREGABALIN (Medsource Pharmaceuticals), PREGABALIN (Medsource Pharmaceuticals), PREGABALIN (Medsource Pharmaceuticals), PREGABALIN (Nivagen Pharmaceuticals), PREGABALIN (Novadoz Pharmaceuticals LLC), PREGABALIN (Novadoz Pharmaceuticals LLC), PREGABALIN (NuCare Pharmaceuticals), PREGABALIN (NuCare Pharmaceuticals), PREGABALIN (Patrin Pharma), PREGABALIN (Preferred Pharmaceuticals), PREGABALIN (Preferred Pharmaceuticals), PREGABALIN (Preferred Pharmaceuticals), PREGABALIN (Preferred Pharmaceuticals), PREGABALIN (Preferred Pharmaceuticals), PREGABALIN (Preferred Pharmaceuticals), PREGABALIN (Preferred Pharmaceuticals), PREGABALIN (Preferred Pharmaceuticals), PREGABALIN (Preferred Pharmaceuticals), PREGABALIN (Preferred Pharmaceuticals), PREGABALIN (Preferred Pharmaceuticals), PREGABALIN (Preferred Pharmaceuticals), PREGABALIN (Preferred Pharmaceuticals), PREGABALIN (Proficient Rx LP), PREGABALIN (Proficient Rx LP), PREGABALIN (Proficient Rx LP), PREGABALIN (Proficient Rx LP), PREGABALIN (Proficient Rx LP), PREGABALIN (Proficient Rx LP), PREGABALIN (Proficient Rx LP), PREGABALIN (Proficient Rx LP), PREGABALIN (Proficient Rx LP), PREGABALIN (Proficient Rx LP), PREGABALIN (Proficient Rx LP), PREGABALIN (Proficient Rx LP), PREGABALIN (Proficient Rx LP), PREGABALIN (Proficient Rx LP), PREGABALIN (Proficient Rx LP), PREGABALIN (Proficient Rx LP), PREGABALIN (Proficient Rx LP), PREGABALIN (Quality Care Products), PREGABALIN (Quality Care Products), PREGABALIN (Quality Care Products), PREGABALIN (Quality Care Products), PREGABALIN (Quality Care Products), PREGABALIN (REMEDYREPACK), PREGABALIN (REMEDYREPACK), PREGABALIN (REMEDYREPACK), PREGABALIN (REMEDYREPACK), PREGABALIN (REMEDYREPACK), PREGABALIN (REMEDYREPACK), PREGABALIN (REMEDYREPACK), PREGABALIN (REMEDYREPACK), PREGABALIN (REMEDYREPACK), PREGABALIN (REMEDYREPACK), PREGABALIN (REMEDYREPACK), PREGABALIN (REMEDYREPACK), PREGABALIN (REMEDYREPACK), PREGABALIN (REMEDYREPACK), PREGABALIN (REMEDYREPACK), PREGABALIN (REMEDYREPACK), PREGABALIN (REMEDYREPACK), PREGABALIN (REMEDYREPACK), PREGABALIN (Rising Pharma Holdings), PREGABALIN (ST. MARY'S MEDICAL PARK PHARMACY), PREGABALIN (ScieGen Pharmaceuticals), PREGABALIN (Sinotherapeutics), PREGABALIN (Solco Healthcare US), PREGABALIN (St Mary's Medical Park Pharmacy), PREGABALIN (St. Mary's Medical Park Pharmacy), PREGABALIN (St. Mary's Medical Park Pharmacy), PREGABALIN (St. Mary's Medical Park Pharmacy), PREGABALIN (St. Mary's Medical Park Pharmacy), PREGABALIN (Sun Pharmaceutical Industries), PREGABALIN (Sun Pharmaceutical Industries), PREGABALIN (Tris Pharma), PREGABALIN (Westminster Pharmaceuticals), PREGABALIN CAPSULES, CV (Cipla USA), PREGABALIN EXTENDED RELEASE (ScieGen Pharmaceuticals)
Formula
C8H17NO2
Exact mass
159.1259
Mol weight
159.23
Structure
Class
Neuropsychiatric agent
 DG01574  Calcium channel alpha-2 delta blocker
 DG03199  Antiepileptic agent
  DG02037  GABA mimetic antiepileptic
Remark
Therapeutic category: 1190
ATC code: N02BF02
Product: D02716<JP/US>
Efficacy
Anticonvulsant, Pain relief
  Disease
Diabetic peripheral neuropathy [DS:H01459]
Postherpetic neuralgia [DS:H01624]
Fibromyalgia [DS:H01636]
Comment
GABA [CPD:C00334] analog
Target
CACNA2D [HSA:781 9254 55799 93589] [KO:K04858 K04859 K04860 K04861]
  Pathway
hsa04010  MAPK signaling pathway
Interaction
Structure map
map07033  Anticonvulsants
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02B OTHER ANALGESICS AND ANTIPYRETICS
    N02BF Gabapentinoids
     N02BF02 Pregabalin
      D02716  Pregabalin (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Anticonvulsants
  Gamma-aminobutyric Acid (GABA) Augmenting Agents
   GABA Agents, Other
    Pregabalin
     D02716  Pregabalin (JAN/USAN/INN)
 Central Nervous System Agents
  Fibromyalgia Agents
   Pregabalin
    D02716  Pregabalin (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   119  Miscellaneous
    1190  Miscellaneous
     D02716  Pregabalin (JAN/USAN/INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01574  Calcium channel alpha-2 delta blocker
   D02716  Pregabalin
  DG03199  Antiepileptic agent
   DG02037  GABA mimetic antiepileptic
    D02716  Pregabalin
Drug classes [BR:br08332]
 Neuropsychiatric agent
  DG03199  Antiepileptic agent
   D02716  Pregabalin
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Calcium channels
    CACNA2D
     D02716  Pregabalin (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D02716
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D02716
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D02716
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D02716
Other DBs
CAS: 148553-50-8
PubChem: 17396883
ChEBI: 64356
LigandBox: D02716
NIKKAJI: J702.547E
KCF data

ATOM        11
            1   C1c C    20.4400  -16.3100
            2   C1b C    21.6300  -17.0800
            3   C6a C    22.8900  -16.3100
            4   O6a O    24.0100  -17.0800
            5   O6a O    22.8900  -14.9800
            6   C1b C    19.2500  -17.0100
            7   N1a N    18.0347  -16.3149
            8   C1b C    20.4698  -14.9103
            9   C1c C    19.2508  -14.1713
            10  C1a C    18.0363  -14.8379
            11  C1a C    19.2816  -12.7404
BOND        10
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     3   5 2
            5     1   6 1 #Up
            6     6   7 1
            7     1   8 1
            8     8   9 1
            9     9  10 1
            10    9  11 1

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Ontology (10)   
   KEGG BRITE (10)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (4)   
   KEGG DISEASE (4)   
Drug (4)   
   KEGG DGROUP (2)   
   LigandBox (1)   
   SIDER (1)   
Chemical substance (5)   
   PubChem (1)   
   ChEBI (1)   
   HMDB (1)   
   HSDB (1)   
   NIKKAJI (1)   
Gene (8)   
   KEGG ORTHOLOGY (4)   
   KEGG GENES (4)   
All databases (32)   

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