| Entry |
|
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| Name |
Erythromycin propionate (USAN) |
|---|
| Formula |
C40H71NO14
|
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| Exact mass |
789.4875
|
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| Mol weight |
789.99
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Antibacterial
DG01551 Macrolide antibiotic
DG01874 14-membered ring macrolide antibiotic
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
Transporter inhibitor
DG01622 ABCB1 inhibitor
|
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| Remark |
| Product (DG00436): | D00140<JP/US> D01361<JP/US> D02009<JP/US> D02184<JP> |
|
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| Efficacy |
Antibacterial, Protein biosynthesis inhibitor |
|---|
| Comment |
Active form of prodrug: Erythromycin [DR: D00140]
|
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| Target |
50S ribosomal subunit |
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| Pathway |
|
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| Metabolism |
|
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| Interaction |
CYP inhibition: CYP3A [HSA: 1576 1577 1551]
Transporter inhibition: ABCB1 [HSA: 5243]
|
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D10 ANTI-ACNE PREPARATIONS
D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
D10AF Antiinfectives for treatment of acne
D10AF02 Erythromycin
D02525 Erythromycin propionate (USAN)
J ANTIINFECTIVES FOR SYSTEMIC USE
J01 ANTIBACTERIALS FOR SYSTEMIC USE
J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
J01FA Macrolides
J01FA01 Erythromycin
D02525 Erythromycin propionate (USAN)
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01A ANTIINFECTIVES
S01AA Antibiotics
S01AA17 Erythromycin
D02525 Erythromycin propionate (USAN)
Drug groups [BR:br08330]
Antibacterial
DG01551 Macrolide antibiotic
DG01874 14-membered ring macrolide antibiotic
DG00436 Erythromycin
D02525 Erythromycin propionate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG00436 Erythromycin
D02525 Erythromycin propionate
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG00436 Erythromycin
D02525 Erythromycin propionate
Transporter inhibitor
DG01622 ABCB1 inhibitor
DG00436 Erythromycin
D02525 Erythromycin propionate
Antimicrobials [BR:br08307]
Antibacterials
Protein biosynthesis inhibitor
Macrolide
D02525 Erythromycin propionate (USAN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D02525
Drug transporters
D02525
Prodrugs [br08324.html]
D02525
Drug groups [BR:br08330]
Antibacterial
DG01551 Macrolide antibiotic
DG01874 14-membered ring macrolide antibiotic
DG00436 Erythromycin
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG00436 Erythromycin
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG00436 Erythromycin
Transporter inhibitor
DG01622 ABCB1 inhibitor
DG00436 Erythromycin
Antimicrobials abbreviations [BR:br08327]
Antibacterials
Protein biosynthesis inhibitor
Macrolide
DG00436 Erythromycin
|
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| Other DBs |
|
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| KCF data |
ATOM 55
1 C1y C 27.5803 -10.5165
2 C1z C 27.5803 -9.1533
3 C1y C 26.3962 -11.1924
4 O2a O 30.1215 -11.5828
5 C1x C 26.3962 -8.4717
6 O1a O 28.6084 -8.1656
7 C1a C 28.8626 -9.5864
8 C1y C 26.3962 -12.5556
9 C1a C 25.4255 -10.1707
10 C1y C 31.3493 -8.8380
11 C1y C 26.3962 -7.1027
12 O2a O 27.1356 -13.9130
13 C1y C 25.2236 -13.2373
14 C1y C 32.5174 -9.5292
15 O2x O 31.3613 -7.4753
16 C5x C 25.2236 -6.4268
17 C1a C 27.5803 -6.4268
18 C1y C 28.6516 -14.3309
19 C7x C 24.0395 -12.5556
20 C1a C 25.2236 -14.6003
21 C1y C 33.7729 -8.8676
22 O7a O 32.5783 -11.7369
23 C1y C 32.5517 -6.8110
24 C1y C 24.0395 -7.1027
25 O5x O 25.2236 -5.0636
26 C1x C 28.6516 -15.6884
27 O2x O 29.8358 -13.6494
28 O7x O 24.0395 -11.1924
29 O6a O 22.9824 -13.5029
30 C1x C 33.7173 -7.5100
31 N1c N 34.8758 -9.5560
32 C1a C 32.5714 -5.4505
33 C1y C 24.0395 -8.4717
34 C1a C 22.8612 -6.4268
35 C1z C 29.8358 -16.3758
36 C1y C 31.0082 -14.3309
37 C1y C 22.8612 -10.5165
38 C1z C 22.8612 -9.1533
39 O1a O 25.2236 -9.1533
40 C1y C 31.0082 -15.6884
41 O2a O 29.8358 -17.6986
42 C1a C 31.2798 -17.3578
43 C1a C 32.1924 -13.6552
44 C1b C 21.6827 -11.1924
45 C1a C 21.6135 -9.7192
46 O1a O 21.6135 -8.4660
47 O1a O 32.1924 -16.3758
48 C1a C 30.9332 -18.6575
49 C1a C 21.7177 -12.3129
50 C1a C 36.1221 -8.8485
51 C7a C 33.7745 -12.4386
52 O6a O 33.7745 -13.8386
53 C1b C 34.9542 -11.7630
54 C1a C 36.1447 -12.4561
55 C1a C 34.8758 -10.9560
BOND 57
1 1 2 1
2 1 3 1
3 1 4 1 #Down
4 2 5 1
5 2 6 1 #Up
6 2 7 1 #Down
7 3 8 1
8 3 9 1 #Down
9 10 4 1 #Down
10 5 11 1
11 8 12 1 #Down
12 8 13 1
13 10 14 1
14 10 15 1
15 11 16 1
16 11 17 1 #Down
17 18 12 1 #Down
18 13 19 1
19 13 20 1 #Up
20 14 21 1
21 14 22 1 #Up
22 15 23 1
23 16 24 1
24 16 25 2
25 18 26 1
26 18 27 1
27 19 28 1
28 19 29 2
29 21 30 1
30 21 31 1 #Down
31 23 32 1 #Down
32 24 33 1
33 24 34 1 #Up
34 26 35 1
35 27 36 1
36 28 37 1
37 33 38 1
38 33 39 1 #Up
39 35 40 1
40 35 41 1 #Down
41 35 42 1
42 36 43 1 #Up
43 37 44 1 #Down
44 38 45 1 #Down
45 38 46 1 #Up
46 40 47 1 #Down
47 41 48 1
48 44 49 1
49 23 30 1
50 36 40 1
51 37 38 1
52 31 50 1
53 22 51 1
54 51 52 2
55 51 53 1
56 53 54 1
57 31 55 1
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