[go: up one dir, main page]
More Web Proxy on the site http://driver.im/
KEGG   DRUG: Lopinavir and ritonavir
Entry
D02498            Mixture   Drug                                   
Name
Lopinavir and ritonavir;
Kaletra (TN)
  Abbr
LPV/r
Product
KALETRA (AbbVie), KALETRA (NuCare Pharmaceuticals)
  Generic
LOPINAVIR AND RITONAVIR (Camber Pharmaceuticals), LOPINAVIR AND RITONAVIR (Laurus Labs Limited), LOPINAVIR AND RITONAVIR (Macleods Pharmaceuticals Limited), LOPINAVIR AND RITONAVIR (NuCare Pharmaceuticals), LOPINAVIR-RITONAVIR (Lannett Company)
Formula
C37H48N6O5S2. C37H48N4O5
Exact mass
1348.6752
Mol weight
1349.75
Structure
Component
Lopinavir [DR:D01425], Ritnavir [DR:D00427]
Class
Antiviral
 DG03107  Anti-HIV agent
  DG01647  HIV protease inhibitor
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
Metabolizing enzyme inhibitor
 DG02852  CYP3A/CYP3A4 inhibitor
Remark
Therapeutic category: 6250
ATC code: J05AR10
Product: D02498<JP/US>
Efficacy
Antiviral
  Disease
HIV-1 infection [DS:H01563]
Target
HIV protease [KO:K22599]
  Pathway
ko03230  Viral genome structure
ko03250  Viral life cycle - HIV-1
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
CYP inhibition: CYP3A [HSA:1576 1577 1551]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AR Antivirals for treatment of HIV infections, combinations
     J05AR10 Lopinavir and ritonavir
      D02498  Lopinavir and ritonavir <JP/US>
USP drug classification [BR:br08302]
 Antivirals
  Anti-HIV Combinations
   Lopinavir/ Ritonavir
    D02498  Lopinavir and ritonavir
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D02498  Lopinavir and ritonavir
Drug groups [BR:br08330]
 Antiviral
  DG03107  Anti-HIV agent
   DG01647  HIV protease inhibitor
    D02498  Lopinavir and ritonavir
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   D02498  Lopinavir and ritonavir
 Metabolizing enzyme inhibitor
  DG02852  CYP3A/CYP3A4 inhibitor
   D02498  Lopinavir and ritonavir
Drug classes [BR:br08332]
 Antiviral
  DG03107  Anti-HIV agent
   D02498  Lopinavir and ritonavir
Antimicrobials [BR:br08307]
 Antivirals
  Polyprotein cleavage inhibitor
   HIV protease inhibitor
    D02498  Lopinavir and ritonavir <JP/US>
Antimicrobials abbreviations [BR:br08327]
 Antivirals
  Polyprotein cleavage inhibitor
   HIV protease inhibitor
    D02498  Lopinavir and ritonavir
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D02498
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D02498
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D02498
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D02498
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D02498
Other DBs
CAS: 369372-47-4
PubChem: 17396672
ChEBI: 145924
LigandBox: D02498
KCF data

ATOM        96
            1   C1c C    33.1595  -13.2660
            2   C1b C    33.1667  -14.6594
            3   C1b C    34.3723  -12.5730
            4   N1b N    31.9539  -12.5803
            5   C8y C    34.1485  -15.6485
            6   C1c C    35.5778  -13.2589
            7   C5a C    30.7482  -13.2734
            8   C1c C    36.7763  -12.5660
            9   O1a O    35.5851  -14.6522
            10  C1c C    29.5429  -12.5875
            11  O5a O    30.7482  -14.6666
            12  C1b C    36.7763  -11.1654
            13  N1b N    37.9817  -13.2516
            14  N1b N    28.3301  -13.2805
            15  C1c C    29.5355  -10.7691
            16  C8y C    35.5632  -10.4651
            17  C7a C    39.1944  -12.5586
            18  C5a C    27.1244  -12.5947
            19  C1a C    30.7482  -10.0688
            20  C1a C    28.3228  -10.0688
            21  C8x C    35.5632   -9.0720
            22  C8x C    34.3650  -11.1725
            23  O7a O    40.4002  -13.2445
            24  O6a O    39.1869  -11.1581
            25  N1c N    25.9261  -13.2878
            26  O5a O    27.1244  -11.1943
            27  C8x C    34.3578   -8.3790
            28  C8x C    33.1523  -10.4722
            29  C1b C    41.6057  -12.5515
            30  C1b C    24.7204  -12.6021
            31  C1a C    25.9261  -14.6811
            32  C8x C    33.1523   -9.0791
            33  C8y C    42.8111  -13.2372
            34  C8y C    23.5077  -13.2949
            35  C8x C    42.8741  -14.6306
            36  S2x S    44.1396  -12.8184
            37  N5x N    22.1649  -12.9341
            38  C8x C    23.5099  -14.6882
            39  N5x N    44.1251  -15.0636
            40  C8x C    44.9479  -13.9448
            41  C8y C    21.3927  -14.1035
            42  S2x S    22.2734  -15.1864
            43  C1c C    19.9994  -14.0990
            44  C1a C    19.2485  -12.9293
            45  C1a C    19.3640  -15.3477
            46  C8x C    35.5479  -15.6485
            47  C8x C    33.4488  -16.8604
            48  C8x C    34.1485  -18.0723
            49  C8x C    35.5479  -18.0723
            50  C8x C    36.2476  -16.8604
            51  C8x C    29.3761  -24.4774
            52  C8x C    28.6867  -25.6808
            53  C8x C    27.2998  -25.6851
            54  C8x C    26.6024  -24.4864
            55  C8y C    27.2920  -23.2830
            56  C8x C    28.6788  -23.2786
            57  C1b C    26.5914  -22.0787
            58  C8y C    36.2179  -20.6854
            59  O2a O    35.0145  -19.9887
            60  C1b C    33.8113  -20.6854
            61  C5a C    32.6080  -19.9887
            62  N1b N    31.4046  -20.6854
            63  C1c C    30.2013  -19.9887
            64  C1c C    28.9981  -20.6854
            65  C1b C    27.7947  -19.9887
            66  C1c C    26.5914  -20.6854
            67  N1b N    25.3881  -19.9887
            68  C5a C    24.1849  -20.6854
            69  C1c C    22.9816  -19.9887
            70  N1y N    21.7783  -20.6854
            71  C8y C    37.4228  -19.9916
            72  C8x C    38.6261  -20.6882
            73  C8x C    38.6244  -22.0787
            74  C8x C    37.4194  -22.7725
            75  C8y C    36.2162  -22.0758
            76  C1a C    37.4245  -18.5983
            77  C1a C    35.0088  -22.7710
            78  O5a O    32.6080  -18.5955
            79  C1b C    30.2013  -18.5955
            80  C8y C    28.9949  -17.8988
            81  C8x C    27.7966  -18.5948
            82  C8x C    26.5901  -17.8981
            83  C8x C    26.5901  -16.5049
            84  C8x C    27.7966  -15.8082
            85  C8x C    29.0033  -16.5049
            86  O1a O    29.0028  -22.0751
            87  O5a O    24.1849  -22.0787
            88  C1c C    22.9816  -18.1782
            89  C1a C    21.7750  -17.4816
            90  C1a C    24.1883  -17.4816
            91  C1x C    21.7800  -22.0758
            92  C1x C    20.5766  -22.7725
            93  C1x C    19.3717  -22.0787
            94  N1x N    19.3700  -20.6882
            95  C5x C    20.5732  -19.9916
            96  O5x O    20.5718  -18.5983
BOND        102
            1     1   2 1 #Down
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     4   7 1
            7     6   8 1
            8     6   9 1 #Up
            9     7  10 1
            10    7  11 2
            11    8  12 1 #Down
            12    8  13 1
            13   10  14 1
            14   10  15 1 #Up
            15   12  16 1
            16   13  17 1
            17   14  18 1
            18   15  19 1
            19   15  20 1
            20   16  21 2
            21   16  22 1
            22   17  23 1
            23   17  24 2
            24   18  25 1
            25   18  26 2
            26   21  27 1
            27   22  28 2
            28   23  29 1
            29   25  30 1
            30   25  31 1
            31   27  32 2
            32   29  33 1
            33   30  34 1
            34   33  35 2
            35   33  36 1
            36   34  37 1
            37   34  38 2
            38   35  39 1
            39   36  40 1
            40   37  41 2
            41   38  42 1
            42   41  43 1
            43   43  44 1
            44   43  45 1
            45   28  32 1
            46   39  40 2
            47   41  42 1
            48    5  46 1
            49    5  47 2
            50   47  48 1
            51   48  49 2
            52   49  50 1
            53   46  50 2
            54   71  72 1
            55   72  73 2
            56   73  74 1
            57   74  75 2
            58   75  58 1
            59   62  63 1
            60   71  76 1
            61   75  77 1
            62   63  64 1
            63   61  78 2
            64   55  57 1
            65   63  79 1 #Down
            66   64  65 1
            67   79  80 1
            68   51  52 2
            69   65  66 1
            70   52  53 1
            71   66  67 1
            72   58  59 1
            73   80  81 2
            74   81  82 1
            75   82  83 2
            76   83  84 1
            77   84  85 2
            78   85  80 1
            79   64  86 1 #Up
            80   66  57 1 #Down
            81   67  68 1
            82   53  54 2
            83   68  87 2
            84   68  69 1
            85   69  88 1 #Up
            86   59  60 1
            87   88  89 1
            88   69  70 1
            89   88  90 1
            90   54  55 1
            91   60  61 1
            92   55  56 2
            93   61  62 1
            94   56  51 1
            95   70  91 1
            96   91  92 1
            97   92  93 1
            98   93  94 1
            99   94  95 1
            100  95  70 1
            101  58  71 2
            102  95  96 2

» Japanese version   » Back

  All links  
Ontology (12)   
   KEGG BRITE (12)   
Disease (1)   
   KEGG DISEASE (1)   
Drug (4)   
   KEGG DGROUP (3)   
   LigandBox (1)   
Chemical substance (2)   
   PubChem (1)   
   ChEBI (1)   
Gene (1)   
   KEGG ORTHOLOGY (1)   
All databases (20)   

Download RDF
DBGET integrated database retrieval system