| Entry |
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| Name |
Hydrocortisone valerate (USP);
Westcort (TN) |
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| Product |
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| Generic |
|
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| Formula |
C26H38O6
|
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| Exact mass |
446.2668
|
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| Mol weight |
446.58
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| Structure |
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| Simcomp |
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| Class |
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
|
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| Remark |
| Product (DG00012): | D00088<JP/US> D00165<US> D00977<JP> D00978<JP/US> D01619<JP/US> D01886<JP/US> D02288<US> |
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| Efficacy |
Anti-inflammatory, Glucocorticoid receptor agonist |
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| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
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| Metabolism |
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| Interaction |
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| Structure map |
| map07225 | Glucocorticoid and mineralocorticoid receptor agonists/antagonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A01 STOMATOLOGICAL PREPARATIONS
A01A STOMATOLOGICAL PREPARATIONS
A01AC Corticosteroids for local oral treatment
A01AC03 Hydrocortisone
D02288 Hydrocortisone valerate (USP) <US>
A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
A07E INTESTINAL ANTIINFLAMMATORY AGENTS
A07EA Corticosteroids acting locally
A07EA02 Hydrocortisone
D02288 Hydrocortisone valerate (USP) <US>
C CARDIOVASCULAR SYSTEM
C05 VASOPROTECTIVES
C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
C05AA Corticosteroids
C05AA01 Hydrocortisone
D02288 Hydrocortisone valerate (USP) <US>
D DERMATOLOGICALS
D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
D07A CORTICOSTEROIDS, PLAIN
D07AA Corticosteroids, weak (group I)
D07AA02 Hydrocortisone
D02288 Hydrocortisone valerate (USP) <US>
D07X CORTICOSTEROIDS, OTHER COMBINATIONS
D07XA Corticosteroids, weak, other combinations
D07XA01 Hydrocortisone
D02288 Hydrocortisone valerate (USP) <US>
H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
H02 CORTICOSTEROIDS FOR SYSTEMIC USE
H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
H02AB Glucocorticoids
H02AB09 Hydrocortisone
D02288 Hydrocortisone valerate (USP) <US>
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01B ANTIINFLAMMATORY AGENTS
S01BA Corticosteroids, plain
S01BA02 Hydrocortisone
D02288 Hydrocortisone valerate (USP) <US>
S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
S01CB Corticosteroids/antiinfectives/mydriatics in combination
S01CB03 Hydrocortisone
D02288 Hydrocortisone valerate (USP) <US>
S02 OTOLOGICALS
S02B CORTICOSTEROIDS
S02BA Corticosteroids
S02BA01 Hydrocortisone
D02288 Hydrocortisone valerate (USP) <US>
USP drug classification [BR:br08302]
Dermatological Agents
Dermatitis and Pruitus Agents
Glucocorticoids, Medium Potency
Hydrocortisone
D02288 Hydrocortisone valerate (USP)
Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
Hydrocortisone
D02288 Hydrocortisone valerate (USP)
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00012 Hydrocortisone
D02288 Hydrocortisone valerate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG00012 Hydrocortisone
D02288 Hydrocortisone valerate
Drug classes [BR:br08332]
Anti-inflammatory
DG01955 Corticosteroid
D02288 Hydrocortisone valerate
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C1 (GR)
D02288 Hydrocortisone valerate (USP) <US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D02288
Topical steroids potency [br08317.html]
Classification in the USA
D02288
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00012 Hydrocortisone
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG00012 Hydrocortisone
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| Other DBs |
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| KCF data |
ATOM 32
1 C1y C 15.2600 -7.7700
2 C1y C 14.0700 -8.4700
3 C1z C 15.2600 -6.4400
4 C1x C 17.5700 -7.7700
5 C1y C 12.8800 -7.7700
6 C1x C 14.0700 -9.8000
7 C1z C 16.4500 -5.7400
8 C1x C 14.0700 -5.7400
9 C1a C 15.2600 -5.0400
10 C1x C 17.5700 -6.4400
11 C1z C 11.6900 -8.4700
12 C1y C 12.8800 -6.4400
13 C1x C 12.8800 -10.5000
14 C5a C 16.4500 -4.3400
15 C2y C 11.6900 -9.8000
16 C1x C 10.5000 -7.7700
17 C1a C 11.6900 -7.0700
18 O1a O 11.6900 -5.7400
19 C1b C 17.6400 -3.6400
20 O5a O 15.2600 -3.6400
21 C2x C 10.5000 -10.5000
22 C1x C 9.3100 -8.4700
23 O1a O 18.8300 -4.3400
24 C5x C 9.3100 -9.8000
25 O5x O 8.1200 -10.5000
26 O7a O 17.6745 -5.0613
27 C7a C 18.8397 -5.7615
28 C1b C 20.0658 -5.0820
29 C1b C 21.2960 -5.8210
30 C1b C 22.5127 -5.1462
31 C1a C 23.7480 -5.8876
32 O6a O 18.8155 -7.1399
BOND 35
1 1 2 1
2 1 3 1
3 1 4 1
4 2 5 1
5 2 6 1
6 3 7 1
7 3 8 1
8 3 9 1 #Up
9 4 10 1
10 5 11 1
11 5 12 1
12 6 13 1
13 7 14 1 #Up
14 11 15 1
15 11 16 1
16 11 17 1 #Up
17 12 18 1 #Up
18 14 19 1
19 14 20 2
20 15 21 2
21 16 22 1
22 19 23 1
23 21 24 1
24 24 25 2
25 7 10 1
26 8 12 1
27 13 15 1
28 22 24 1
29 7 26 1 #Down
30 26 27 1
31 27 28 1
32 28 29 1
33 29 30 1
34 30 31 1
35 27 32 2
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