| Entry |
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| Name |
Mebhydrolin napadisilate (JAN) |
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| Formula |
(C19H20N2)2. C10H8O6S2
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| Exact mass |
840.3015
|
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| Mol weight |
841.05
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| Structure |
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| Simcomp |
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| Class |
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
|
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| Remark |
|
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| Efficacy |
Antiallergic, H1 receptor antagonist |
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| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04750 | Inflammatory mediator regulation of TRP channels |
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| Interaction |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
R06 ANTIHISTAMINES FOR SYSTEMIC USE
R06A ANTIHISTAMINES FOR SYSTEMIC USE
R06AX Other antihistamines for systemic use
R06AX15 Mebhydrolin
D01786 Mebhydrolin napadisilate (JAN)
Risk category of Japanese OTC drugs [BR:br08312]
Second-class OTC drugs
Inorganic and organic chemicals
Mebhydrolin
D01786 Mebhydrolin napadisilate (JAN)
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG01113 Mebhydrolin
D01786 Mebhydrolin napadisilate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Histamine
HRH1
D01786 Mebhydrolin napadisilate (JAN)
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG01113 Mebhydrolin
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| Other DBs |
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| KCF data |
ATOM 60
1 C8x C 16.2400 -14.0700
2 C8x C 16.2400 -15.4700
3 C8x C 17.4300 -16.1700
4 C8x C 17.4300 -13.3700
5 C8y C 18.6900 -14.0700
6 C8y C 18.6900 -15.4700
7 N4y N 20.0200 -15.9600
8 C8y C 20.0200 -13.6500
9 C8y C 20.7900 -14.8400
10 C1x C 22.1900 -14.7000
11 C1x C 22.8200 -13.3700
12 N1y N 21.9800 -12.2500
13 C1x C 20.5800 -12.3900
14 C1a C 22.5400 -10.9900
15 C1b C 20.0200 -17.3600
16 C8y C 21.2324 -18.0600
17 C8x C 21.2324 -19.4598
18 C8x C 22.4449 -20.1598
19 C8x C 23.6573 -19.4598
20 C8x C 23.6573 -18.0600
21 C8x C 22.4449 -17.3600
22 C8x C 26.7400 -14.6300
23 C8x C 26.7400 -16.0300
24 C8x C 27.9524 -16.7300
25 C8y C 29.1649 -16.0300
26 C8y C 29.1649 -14.6300
27 C8y C 27.9524 -13.9300
28 C8y C 30.3773 -16.7300
29 C8x C 31.5897 -16.0300
30 C8x C 31.5897 -14.6300
31 C8x C 30.3773 -13.9300
32 S4a S 27.9524 -12.5302
33 S4a S 30.3773 -18.1300
34 O1d O 30.3773 -19.5300
35 O1d O 31.7800 -18.1300
36 O1d O 28.9800 -18.1300
37 O1d O 27.9524 -11.1302
38 O1d O 26.5300 -12.5302
39 O1d O 29.3300 -12.5302
40 C8x C 16.2400 -14.0700
41 C8x C 17.4300 -13.3700
42 C8y C 18.6900 -14.0700
43 C8y C 18.6900 -15.4700
44 N4y N 20.0200 -15.9600
45 C8y C 20.7900 -14.8400
46 C8y C 20.0200 -13.6500
47 C1x C 20.5800 -12.3900
48 N1y N 21.9800 -12.2500
49 C1a C 22.5400 -10.9900
50 C1x C 22.8200 -13.3700
51 C1x C 22.1900 -14.7000
52 C1b C 20.0200 -17.3600
53 C8y C 21.2324 -18.0600
54 C8x C 21.2324 -19.4598
55 C8x C 22.4449 -20.1598
56 C8x C 23.6573 -19.4598
57 C8x C 23.6573 -18.0600
58 C8x C 22.4449 -17.3600
59 C8x C 17.4300 -16.1700
60 C8x C 16.2400 -15.4700
BOND 67
1 22 23 2
2 23 24 1
3 24 25 2
4 25 26 1
5 26 27 2
6 22 27 1
7 25 28 1
8 28 29 2
9 29 30 1
10 30 31 2
11 26 31 1
12 27 32 1
13 28 33 1
14 33 34 1
15 33 35 2
16 33 36 2
17 32 37 1
18 32 38 2
19 32 39 2
20 5 6 1
21 6 7 1
22 7 9 1
23 8 5 1
24 3 6 2
25 12 14 1
26 5 4 2
27 4 1 1
28 1 2 2
29 2 3 1
30 8 9 2
31 9 10 1
32 10 11 1
33 11 12 1
34 12 13 1
35 13 8 1
36 7 15 1
37 15 16 1
38 16 17 2
39 17 18 1
40 18 19 2
41 19 20 1
42 20 21 2
43 16 21 1
44 42 43 1
45 43 44 1
46 44 45 1
47 46 42 1
48 59 43 2
49 48 49 1
50 42 41 2
51 41 40 1
52 40 60 2
53 60 59 1
54 46 45 2
55 45 51 1
56 51 50 1
57 50 48 1
58 48 47 1
59 47 46 1
60 44 52 1
61 52 53 1
62 53 54 2
63 54 55 1
64 55 56 2
65 56 57 1
66 57 58 2
67 53 58 1
BRACKET 1 15.9600 -20.8600 15.9600 -10.2900
1 24.2900 -10.2900 24.2900 -20.8600
1 2
ORIGINAL 1 1 4 5 6 7 9 8 13 12 14 11 10 15 16 17 18
1 19 20 21 3 2
REPEAT 1 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55
1 56 57 58 59 60
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