| Entry |
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| Name |
Dexamethasone palmitate (JAN);
Dexamethasone 21-palmitate;
Limethason (TN) |
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| Formula |
C38H59FO6
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| Exact mass |
630.4296
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| Mol weight |
630.87
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| Structure |
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| Simcomp |
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| Class |
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
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| Remark |
| Therapeutic category: | 2454 |
| Product (DG00011): | D00292<JP/US> D00975<JP/US> D01510<JP> D01615<JP> D01632<JP> D01948<JP> D07073<JP> |
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| Efficacy |
Anti-inflammatory, Antirheumatic, Glucocorticoid receptor agonist |
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| Target |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
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| Interaction |
CYP induction: CYP3A4 [HSA: 1576]
|
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| Structure map |
| map07225 | Glucocorticoid and mineralocorticoid receptor agonists/antagonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A01 STOMATOLOGICAL PREPARATIONS
A01A STOMATOLOGICAL PREPARATIONS
A01AC Corticosteroids for local oral treatment
A01AC02 Dexamethasone
D01615 Dexamethasone palmitate (JAN) <JP>
C CARDIOVASCULAR SYSTEM
C05 VASOPROTECTIVES
C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
C05AA Corticosteroids
C05AA09 Dexamethasone
D01615 Dexamethasone palmitate (JAN) <JP>
D DERMATOLOGICALS
D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
D07A CORTICOSTEROIDS, PLAIN
D07AB Corticosteroids, moderately potent (group II)
D07AB19 Dexamethasone
D01615 Dexamethasone palmitate (JAN) <JP>
D07X CORTICOSTEROIDS, OTHER COMBINATIONS
D07XB Corticosteroids, moderately potent, other combinations
D07XB05 Dexamethasone
D01615 Dexamethasone palmitate (JAN) <JP>
D10 ANTI-ACNE PREPARATIONS
D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
D10AA Corticosteroids, combinations for treatment of acne
D10AA03 Dexamethasone
D01615 Dexamethasone palmitate (JAN) <JP>
H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
H02 CORTICOSTEROIDS FOR SYSTEMIC USE
H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
H02AB Glucocorticoids
H02AB02 Dexamethasone
D01615 Dexamethasone palmitate (JAN) <JP>
R RESPIRATORY SYSTEM
R01 NASAL PREPARATIONS
R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
R01AD Corticosteroids
R01AD03 Dexamethasone
D01615 Dexamethasone palmitate (JAN) <JP>
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01B ANTIINFLAMMATORY AGENTS
S01BA Corticosteroids, plain
S01BA01 Dexamethasone
D01615 Dexamethasone palmitate (JAN) <JP>
S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
S01CB Corticosteroids/antiinfectives/mydriatics in combination
S01CB01 Dexamethasone
D01615 Dexamethasone palmitate (JAN) <JP>
S02 OTOLOGICALS
S02B CORTICOSTEROIDS
S02BA Corticosteroids
S02BA06 Dexamethasone
D01615 Dexamethasone palmitate (JAN) <JP>
S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
S03B CORTICOSTEROIDS
S03BA Corticosteroids
S03BA01 Dexamethasone
D01615 Dexamethasone palmitate (JAN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
24 Hormones
245 Adrenal hormone preparations
2454 Fluorinated adrenocorticotropic hormones
D01615 Dexamethasone palmitate (JAN)
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00011 Dexamethasone
D01615 Dexamethasone palmitate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00011 Dexamethasone
D01615 Dexamethasone palmitate
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
DG00011 Dexamethasone
D01615 Dexamethasone palmitate
Drug classes [BR:br08332]
Anti-inflammatory
DG01955 Corticosteroid
D01615 Dexamethasone palmitate
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C1 (GR)
D01615 Dexamethasone palmitate (JAN) <JP>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01615
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00011 Dexamethasone
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00011 Dexamethasone
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
DG00011 Dexamethasone
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| Other DBs |
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| KCF data |
ATOM 45
1 C1z C 11.5428 -18.6613
2 C1y C 12.6894 -19.3399
3 C1z C 10.3788 -19.3282
4 C1y C 11.5545 -17.3219
5 X F 11.5136 -19.9425
6 C1y C 13.8535 -18.6790
7 C1x C 12.6894 -20.6736
8 C2y C 10.3730 -20.6619
9 C2x C 9.2263 -18.6556
10 C1a C 10.3670 -17.8307
11 C1x C 12.7128 -16.6667
12 O1a O 10.3962 -16.6491
13 C1z C 13.8653 -17.3393
14 C1x C 16.1525 -18.7081
15 C1x C 11.5311 -21.3406
16 C2x C 9.2263 -21.3348
17 C2x C 8.0622 -19.3282
18 C1z C 15.0234 -16.6959
19 C1a C 13.8944 -16.0113
20 C1y C 16.1700 -17.3685
21 C5x C 8.0622 -20.6619
22 C5a C 15.0351 -14.7947
23 O1a O 16.6673 -15.7423
24 C1a C 17.3401 -16.7133
25 O5x O 6.9039 -21.3348
26 C1b C 16.1875 -14.1043
27 O5a O 13.8944 -14.1863
28 O7a O 17.3516 -14.7537
29 C7a C 18.5545 -14.0501
30 C1b C 19.7633 -14.7498
31 C1b C 20.9720 -14.0501
32 C1b C 22.1807 -14.7498
33 C1b C 23.3894 -14.0501
34 C1b C 24.5981 -14.7498
35 C1b C 25.8068 -14.0501
36 C1b C 27.0155 -14.7498
37 C1b C 28.2242 -14.0501
38 C1b C 29.4330 -14.7498
39 C1b C 30.6417 -14.0501
40 C1b C 31.8504 -14.7498
41 C1b C 33.0591 -14.0501
42 C1b C 34.2678 -14.7498
43 C1b C 35.4765 -14.0501
44 C1a C 36.6852 -14.7498
45 O6a O 18.5772 -12.6721
BOND 48
1 18 23 1 #Down
2 20 24 1 #Down
3 21 25 2
4 22 26 1
5 22 27 2
6 26 28 1
7 8 15 1
8 11 13 1
9 17 21 1
10 18 20 1
11 1 2 1
12 1 3 1
13 1 4 1
14 1 5 1 #Down
15 2 6 1
16 28 29 1
17 2 7 1
18 29 30 1
19 3 8 1
20 30 31 1
21 3 9 1
22 31 32 1
23 3 10 1 #Up
24 32 33 1
25 4 11 1
26 33 34 1
27 4 12 1 #Up
28 34 35 1
29 6 13 1
30 35 36 1
31 6 14 1
32 36 37 1
33 7 15 1
34 37 38 1
35 8 16 2
36 38 39 1
37 9 17 2
38 39 40 1
39 13 18 1
40 40 41 1
41 13 19 1 #Up
42 41 42 1
43 14 20 1
44 42 43 1
45 16 21 1
46 43 44 1
47 18 22 1 #Up
48 29 45 2
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