| Entry |
|
|---|
| Name |
Colforsin daropate hydrochloride (JAN);
Nkh 477;
Adehl (TN) |
|---|
| Formula |
C27H43NO8. HCl
|
|---|
| Exact mass |
545.2755
|
|---|
| Mol weight |
546.09
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01703 Cardiotonic
DG01499 Adenylate cyclase activator
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
|
|---|
| Remark |
| Therapeutic category: | 2119 |
| Product (DG02877): | D01697<JP> |
|
|---|
| Efficacy |
Cardiotonic, Adenylate cyclase activator |
|---|
| Comment |
Forskolin [DR: D03584] water-soluble derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
| hsa04270 | Vascular smooth muscle contraction |
|
|---|
| Metabolism |
|
|---|
| Interaction |
|
|---|
| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
211 Cardiotonics
2119 Others
D01697 Colforsin daropate hydrochloride (JAN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01703 Cardiotonic
D01697 Colforsin daropate hydrochloride
DG01499 Adenylate cyclase activator
DG02877 Colforsin
D01697 Colforsin daropate hydrochloride
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02877 Colforsin
D01697 Colforsin daropate hydrochloride
Target-based classification of drugs [BR:br08310]
Enzymes
Lyases (EC4)
Phosphorus-oxygen lyases
ADCY
D01697 Colforsin daropate hydrochloride (JAN) <JP>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01697
Drug groups [BR:br08330]
Cardiovascular agent
DG01499 Adenylate cyclase activator
DG02877 Colforsin
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02877 Colforsin
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 37
1 C1x C 18.3442 -13.2378
2 C1x C 18.3442 -14.7146
3 C1z C 19.5061 -15.3836
4 C1y C 19.5061 -12.5685
5 C1z C 20.6611 -13.2378
6 C1y C 20.6553 -14.7146
7 C1y C 21.8116 -15.3884
8 C1y C 22.9733 -14.7245
9 C1z C 21.8229 -12.5733
10 C1z C 22.9733 -13.2504
11 O2x O 24.1348 -12.5923
12 C1z C 24.1460 -10.6643
13 C1x C 22.9954 -9.9875
14 C5x C 21.8332 -10.6455
15 C2b C 25.2995 -9.9947
16 C2a C 26.4553 -10.6573
17 O7a O 21.8762 -17.9169
18 O7a O 24.1310 -15.3960
19 C1a C 22.9609 -11.9060
20 C1a C 20.6491 -11.8994
21 O1a O 19.4932 -11.2301
22 O1a O 21.8089 -13.9068
23 O5x O 20.6686 -9.9744
24 C1a C 19.5108 -17.0754
25 C1a C 18.3374 -16.0461
26 C7a C 23.0313 -18.5744
27 C1b C 24.1871 -17.9053
28 C1b C 25.3429 -18.5675
29 O6a O 23.0252 -19.9126
30 C7a C 25.2914 -14.7294
31 O6a O 25.2944 -13.3910
32 C1a C 26.4252 -15.3665
33 C1a C 25.3496 -11.6418
34 N1c N 26.5586 -17.8609
35 C1a C 27.7468 -18.5423
36 C1a C 26.5548 -16.4502
37 X Cl 30.5215 -14.9848
BOND 38
1 7 8 1
2 7 17 1 #Up
3 8 10 1
4 8 18 1 #Up
5 9 5 1
6 10 19 1 #Up
7 3 6 1
8 5 20 1 #Up
9 5 4 1
10 4 21 1 #Down
11 4 1 1
12 9 22 1 #Down
13 14 23 2
14 1 2 1
15 3 24 1
16 9 10 1
17 3 25 1
18 10 11 1
19 17 26 1
20 11 12 1
21 26 27 1
22 12 13 1
23 27 28 1
24 13 14 1
25 26 29 2
26 14 9 1
27 18 30 1
28 30 32 1
29 2 3 1
30 30 31 2
31 12 15 1
32 5 6 1
33 15 16 2
34 6 7 1
35 12 33 1 #Up
36 28 34 1
37 34 35 1
38 34 36 1
|
|---|