| Entry |
|
|---|
| Name |
Bufetolol hydrochloride (JP18);
Adobiol (TN) |
|---|
| Formula |
C18H29NO4. HCl
|
|---|
| Exact mass |
359.1863
|
|---|
| Mol weight |
359.89
|
|---|
| Structure |
|
|---|
| Class |
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
DG01653 Antiarrhythmics
DG01806 Class II antiarrhythmic agent
|
|---|
| Remark |
| Therapeutic category: | 2123 |
|
|---|
| Efficacy |
Antiarrhythmic, Vasodilator, beta-Adrenergic receptor antagonist |
|---|
| Comment |
Propranolol derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
|
|---|
| Interaction |
|
|---|
| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
212 Antiarrhythmic agents
2123 Beta blockers
D01504 Bufetolol hydrochloride (JP18)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
D01504 Bufetolol hydrochloride
DG01653 Antiarrhythmics
DG01806 Class II antiarrhythmic agent
D01504 Bufetolol hydrochloride
Drug classes [BR:br08332]
Cardiovascular agent
DG01653 Antiarrhythmics
D01504 Bufetolol hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRB
D01504 Bufetolol hydrochloride (JP18) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01504 Bufetolol hydrochloride
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 24
1 X Cl 24.7800 -25.8300
2 C1d C 24.1500 -21.1400
3 C1a C 25.3624 -21.8400
4 N1b N 22.9376 -21.8400
5 C1b C 21.7421 -21.1496
6 C1c C 20.5547 -21.8351
7 C1b C 19.3635 -21.1471
8 O1a O 20.5545 -23.2398
9 O2a O 18.1740 -21.8338
10 C8y C 18.1740 -23.2338
11 C8y C 16.9786 -23.9242
12 C8x C 16.9789 -25.3242
13 C8x C 18.1914 -26.0240
14 C8x C 19.3868 -25.3336
15 C8x C 19.3866 -23.9336
16 O2a O 15.7964 -23.2420
17 C1b C 14.6027 -23.9316
18 C1y C 13.4143 -23.2457
19 O2x O 13.4055 -21.8404
20 C1x C 12.0688 -21.4150
21 C1x C 11.2511 -22.5547
22 C1x C 12.0824 -23.6846
23 C1a C 24.1500 -19.7400
24 C1a C 25.3624 -20.4400
BOND 24
1 2 3 1
2 2 4 1
3 4 5 1
4 5 6 1
5 6 7 1
6 6 8 1
7 7 9 1
8 9 10 1
9 10 11 2
10 11 12 1
11 12 13 2
12 13 14 1
13 14 15 2
14 10 15 1
15 11 16 1
16 16 17 1
17 17 18 1
18 18 19 1
19 19 20 1
20 20 21 1
21 21 22 1
22 18 22 1
23 2 23 1
24 2 24 1
|
|---|