| Entry |
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| Name |
Maprotiline hydrochloride (JP18/USP);
Ludiomil (TN) |
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| Formula |
C20H23N. HCl
|
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| Exact mass |
313.1597
|
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| Mol weight |
313.86
|
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| Structure |
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| Simcomp |
|
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| Class |
Neuropsychiatric agent
DG01730 Non-selective monoamine reuptake inhibitor
DG01729 Tetracyclic antidepressant
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
|
|---|
| Remark |
| Therapeutic category: | 1179 |
| Product (DG00941): | D00818<JP> |
|
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| Efficacy |
Antidepressant, Selective noradrenaline reuptake inhibitor (NRI) |
|---|
| Disease |
Major depressive disorder [DS: H01646] |
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| Target |
|
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| Pathway |
|
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| Metabolism |
Enzyme: CYP2D6 [HSA: 1565]
|
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| Interaction |
|
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| Structure map |
| map07234 | Neurotransmitter transporter inhibitors |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N06 PSYCHOANALEPTICS
N06A ANTIDEPRESSANTS
N06AA Non-selective monoamine reuptake inhibitors
N06AA21 Maprotiline
D00818 Maprotiline hydrochloride (JP18/USP) <JP>
USP drug classification [BR:br08302]
Antidepressants
Antidepressants, Other
Maprotiline
D00818 Maprotiline hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
117 Psychotropics
1179 Others
D00818 Maprotiline hydrochloride (JP18/USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01730 Non-selective monoamine reuptake inhibitor
DG00941 Maprotiline
D00818 Maprotiline hydrochloride
DG01729 Tetracyclic antidepressant
DG00941 Maprotiline
D00818 Maprotiline hydrochloride
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00941 Maprotiline
D00818 Maprotiline hydrochloride
Drug classes [BR:br08332]
Neuropsychiatric agent
DG01730 Non-selective monoamine reuptake inhibitor
D00818 Maprotiline hydrochloride
Target-based classification of drugs [BR:br08310]
Transporters
Solute carrier family
SLC6
SLC6A2 (NAT1)
D00818 Maprotiline hydrochloride (JP18/USP) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00818 Maprotiline hydrochloride
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00818
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01730 Non-selective monoamine reuptake inhibitor
DG00941 Maprotiline
DG01729 Tetracyclic antidepressant
DG00941 Maprotiline
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00941 Maprotiline
|
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| Other DBs |
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| KCF data |
ATOM 22
1 X Cl 29.2600 -16.5200
2 C1x C 20.3000 -16.7300
3 C1x C 20.3000 -17.8500
4 C1z C 19.8100 -15.8200
5 C8y C 18.5500 -16.5200
6 C8y C 21.0700 -16.5200
7 C1b C 19.8100 -14.3500
8 C8y C 18.5500 -17.9200
9 C8x C 17.3600 -15.7500
10 C8y C 21.0700 -17.9900
11 C8x C 22.3300 -15.8200
12 C1b C 21.0700 -13.6500
13 C1y C 19.8100 -18.6900
14 C8x C 17.2900 -18.6200
15 C8x C 16.1000 -16.4500
16 C8x C 22.2600 -18.6900
17 C8x C 23.5200 -16.5900
18 C1b C 22.2600 -14.4200
19 C8x C 16.1000 -17.9200
20 C8x C 23.5200 -17.9900
21 N1b N 23.5200 -13.7200
22 C1a C 24.7800 -14.4200
BOND 24
1 2 3 1
2 4 5 1
3 4 6 1
4 4 7 1
5 5 8 1
6 5 9 2
7 6 10 2
8 6 11 1
9 7 12 1
10 8 13 1
11 8 14 2
12 9 15 1
13 10 16 1
14 11 17 2
15 12 18 1
16 14 19 1
17 16 20 2
18 18 21 1
19 21 22 1
20 10 13 1
21 15 19 2
22 17 20 1
23 3 13 1
24 2 4 1
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