 | | DRUG: Prazosin hydrochloride | |
| Entry |
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| Name |
Prazosin hydrochloride (JP18/USP);
Minipress (TN) |
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| Product |
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| Generic |
PRAZOSIN (Lannett Company), PRAZOSIN HCL (Direct_Rx), PRAZOSIN HCL (Direct_Rx), PRAZOSIN HCL (Direct_Rx), PRAZOSIN HYDROCHLORIDE (A-S Medication Solutions), PRAZOSIN HYDROCHLORIDE (Alembic Pharmaceuticals Limited), PRAZOSIN HYDROCHLORIDE (Alembic Pharmaceuticals), PRAZOSIN HYDROCHLORIDE (American Health Packaging), PRAZOSIN HYDROCHLORIDE (American Health Packaging), PRAZOSIN HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), PRAZOSIN HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), PRAZOSIN HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), PRAZOSIN HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), PRAZOSIN HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), PRAZOSIN HYDROCHLORIDE (Aurobindo Pharma Limited), PRAZOSIN HYDROCHLORIDE (Biocon Pharma), PRAZOSIN HYDROCHLORIDE (Bryant Ranch Prepack), PRAZOSIN HYDROCHLORIDE (Bryant Ranch Prepack), PRAZOSIN HYDROCHLORIDE (Bryant Ranch Prepack), PRAZOSIN HYDROCHLORIDE (Bryant Ranch Prepack), PRAZOSIN HYDROCHLORIDE (Bryant Ranch Prepack), PRAZOSIN HYDROCHLORIDE (Bryant Ranch Prepack), PRAZOSIN HYDROCHLORIDE (Bryant Ranch Prepack), PRAZOSIN HYDROCHLORIDE (Bryant Ranch Prepack), PRAZOSIN HYDROCHLORIDE (Cardinal Health 107), PRAZOSIN HYDROCHLORIDE (Cardinal Health 107), PRAZOSIN HYDROCHLORIDE (Exelan Pharmaceuticals), PRAZOSIN HYDROCHLORIDE (Golden State Medical Supply), PRAZOSIN HYDROCHLORIDE (Granules Pharmaceuticals), PRAZOSIN HYDROCHLORIDE (Greenstone LLC), PRAZOSIN HYDROCHLORIDE (Lifestar Pharma LLC), PRAZOSIN HYDROCHLORIDE (Major Pharmaceuticals), PRAZOSIN HYDROCHLORIDE (Marlex Pharmaceuticals), PRAZOSIN HYDROCHLORIDE (Mylan Institutional), PRAZOSIN HYDROCHLORIDE (Mylan Pharmaceuticals), PRAZOSIN HYDROCHLORIDE (NCS HealthCare of KY), PRAZOSIN HYDROCHLORIDE (Novitium Pharma LLC), PRAZOSIN HYDROCHLORIDE (NuCare Pharmaceuticals), PRAZOSIN HYDROCHLORIDE (NuCare Pharmaceuticals), PRAZOSIN HYDROCHLORIDE (NuCare Pharmaceuticals), PRAZOSIN HYDROCHLORIDE (NuCare Pharmaceuticals), PRAZOSIN HYDROCHLORIDE (NuCare Pharmaceuticals), PRAZOSIN HYDROCHLORIDE (PD-Rx Pharmaceuticals), PRAZOSIN HYDROCHLORIDE (PD-Rx Pharmaceuticals), PRAZOSIN HYDROCHLORIDE (PD-Rx Pharmaceuticals), PRAZOSIN HYDROCHLORIDE (Prasco Laboratories), PRAZOSIN HYDROCHLORIDE (Preferred Pharmaceuticals), PRAZOSIN HYDROCHLORIDE (Preferred Pharmaceuticals), PRAZOSIN HYDROCHLORIDE (Preferred Pharmaceuticals), PRAZOSIN HYDROCHLORIDE (Preferred Pharmaceuticals), PRAZOSIN HYDROCHLORIDE (Preferred Pharmaceuticals), PRAZOSIN HYDROCHLORIDE (Proficient Rx LP), PRAZOSIN HYDROCHLORIDE (Proficient Rx LP), PRAZOSIN HYDROCHLORIDE (Proficient Rx LP), PRAZOSIN HYDROCHLORIDE (REMEDYREPACK), PRAZOSIN HYDROCHLORIDE (REMEDYREPACK), PRAZOSIN HYDROCHLORIDE (REMEDYREPACK), PRAZOSIN HYDROCHLORIDE (REMEDYREPACK), PRAZOSIN HYDROCHLORIDE (REMEDYREPACK), PRAZOSIN HYDROCHLORIDE (REMEDYREPACK), PRAZOSIN HYDROCHLORIDE (REMEDYREPACK), PRAZOSIN HYDROCHLORIDE (REMEDYREPACK), PRAZOSIN HYDROCHLORIDE (REMEDYREPACK), PRAZOSIN HYDROCHLORIDE (REMEDYREPACK), PRAZOSIN HYDROCHLORIDE (Teva Pharmaceuticals USA) |
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| Formula |
C19H21N5O4. HCl
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| Exact mass |
419.1360
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| Mol weight |
419.86
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| Structure |
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| Simcomp |
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| Class |
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
DG01457 alpha1-Adrenergic receptor antagonist
DG01739 Peripherally-acting antiadrenergic
DG03231 Antihypertensive
Transporter inhibitor
DG02881 SLC22A3 inhibitor
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| Remark |
| Therapeutic category: | 2149 |
| Product (DG00253): | D00609<JP/US> |
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| Efficacy |
Antihypertensive, alpha1-Adrenergic receptor antagonist |
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| Disease |
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| Comment |
Prazosin derivative
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| Target |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
| hsa04270 | Vascular smooth muscle contraction |
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| Interaction |
Transporter inhibition: SLC22A3 [HSA: 6581]
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| Structure map |
| map07215 | alpha-Adrenergic receptor agonists/antagonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C02 ANTIHYPERTENSIVES
C02C ANTIADRENERGIC AGENTS, PERIPHERALLY ACTING
C02CA Alpha-adrenoreceptor antagonists
C02CA01 Prazosin
D00609 Prazosin hydrochloride (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Cardiovascular Agents
Alpha-adrenergic Blocking Agents
Prazosin
D00609 Prazosin hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
214 Antihypertensives
2149 Others
D00609 Prazosin hydrochloride (JP18/USP)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
DG01457 alpha1-Adrenergic receptor antagonist
DG00253 Prazosin
D00609 Prazosin hydrochloride
DG01739 Peripherally-acting antiadrenergic
DG00253 Prazosin
D00609 Prazosin hydrochloride
DG03231 Antihypertensive
DG00253 Prazosin
D00609 Prazosin hydrochloride
Transporter inhibitor
DG02881 SLC22A3 inhibitor
DG00253 Prazosin
D00609 Prazosin hydrochloride
Drug classes [BR:br08332]
Cardiovascular agent
DG03231 Antihypertensive
D00609 Prazosin hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRA1
D00609 Prazosin hydrochloride (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00609 Prazosin hydrochloride
Drug metabolizing enzymes and transporters [br08309.html]
Drug transporters
D00609
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
DG01457 alpha1-Adrenergic receptor antagonist
DG00253 Prazosin
DG01739 Peripherally-acting antiadrenergic
DG00253 Prazosin
DG03231 Antihypertensive
DG00253 Prazosin
Transporter inhibitor
DG02881 SLC22A3 inhibitor
DG00253 Prazosin
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| Other DBs |
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| KCF data |
ATOM 29
1 C8y C 33.1529 -18.8898
2 C8y C 33.1529 -17.4829
3 C8x C 34.3789 -19.5962
4 C8y C 31.9444 -19.5962
5 N5x N 31.9444 -16.7997
6 C8x C 34.3789 -16.7997
7 C8y C 35.5815 -18.8898
8 N5x N 30.7358 -18.8898
9 N1a N 31.9444 -20.9974
10 C8y C 30.7358 -17.4829
11 C8y C 35.5815 -17.4829
12 O2a O 36.8134 -19.5962
13 N1y N 29.5273 -16.7997
14 O2a O 36.8134 -16.7997
15 C1a C 38.0162 -18.8839
16 C1x C 29.5273 -15.4044
17 C1x C 28.3071 -17.4829
18 C1a C 38.0162 -17.4944
19 C1x C 28.3071 -14.6979
20 C1x C 27.0985 -16.7997
21 N1y N 27.0985 -15.4044
22 C5a C 25.8726 -14.6979
23 C8y C 24.6581 -15.4044
24 O5a O 25.8726 -13.2909
25 C8x C 24.2844 -16.7355
26 O2x O 23.5022 -14.6220
27 C8x C 22.8541 -16.7063
28 C8x C 22.3929 -15.4803
29 X Cl 41.7809 -18.0958
BOND 31
1 1 2 2
2 1 3 1
3 1 4 1
4 2 5 1
5 2 6 1
6 3 7 2
7 4 8 2
8 4 9 1
9 5 10 2
10 6 11 2
11 7 12 1
12 10 13 1
13 11 14 1
14 12 15 1
15 13 16 1
16 13 17 1
17 14 18 1
18 16 19 1
19 17 20 1
20 19 21 1
21 21 22 1
22 22 23 1
23 22 24 2
24 23 25 2
25 23 26 1
26 25 27 1
27 26 28 1
28 7 11 1
29 8 10 1
30 20 21 1
31 27 28 2
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