| Entry |
|
|---|
| Name |
Carteolol hydrochloride (JP18/USP);
Cartrol (TN);
Ocupress (TN) |
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C16H24N2O3. HCl
|
|---|
| Exact mass |
328.1554
|
|---|
| Mol weight |
328.83
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
DG01653 Antiarrhythmics
DG01806 Class II antiarrhythmic agent
DG03231 Antihypertensive
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
|
|---|
| Remark |
| Product (DG00308): | D00599<JP/US> |
| Product (mixture): | D10804<JP> |
|
|---|
| Efficacy |
Antiglaucoma, Antiarrhythmic, Antihypertensive, beta-Adrenergic receptor antagonist |
|---|
| Disease |
Chronic open-angle glaucoma [DS: H00612] |
|---|
| Comment |
Propranolol derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
|
|---|
| Metabolism |
Enzyme: CYP2D6 [HSA: 1565]
|
|---|
| Interaction |
|
|---|
| Structure map |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C07 BETA BLOCKING AGENTS
C07A BETA BLOCKING AGENTS
C07AA Beta blocking agents, non-selective
C07AA15 Carteolol
D00599 Carteolol hydrochloride (JP18/USP) <JP/US>
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
S01ED Beta blocking agents
S01ED05 Carteolol
D00599 Carteolol hydrochloride (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Ophthalmic Agents
Intraocular Pressure Lowering Agents
Beta-adrenergic Blocking Agents, Ophthalmic
Carteolol
D00599 Carteolol hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
13 Agents affecting sensory organs
131 Ophthalmic agents
1319 Others
D00599 Carteolol hydrochloride (JP18/USP)
2 Agents affecting individual organs
21 Cardiovascular agents
212 Antiarrhythmic agents
2123 Beta blockers
D00599 Carteolol hydrochloride (JP18/USP)
214 Antihypertensives
2149 Others
D00599 Carteolol hydrochloride (JP18/USP)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
DG00308 Carteolol
D00599 Carteolol hydrochloride
DG01653 Antiarrhythmics
DG01806 Class II antiarrhythmic agent
DG00308 Carteolol
D00599 Carteolol hydrochloride
DG03231 Antihypertensive
DG00308 Carteolol
D00599 Carteolol hydrochloride
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
DG00308 Carteolol
D00599 Carteolol hydrochloride
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00308 Carteolol
D00599 Carteolol hydrochloride
Drug classes [BR:br08332]
Cardiovascular agent
DG03231 Antihypertensive
D00599 Carteolol hydrochloride
DG01653 Antiarrhythmics
D00599 Carteolol hydrochloride
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
D00599 Carteolol hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRB
D00599 Carteolol hydrochloride (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00599 Carteolol hydrochloride
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00599
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
DG00308 Carteolol
DG01653 Antiarrhythmics
DG01806 Class II antiarrhythmic agent
DG00308 Carteolol
DG03231 Antihypertensive
DG00308 Carteolol
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
DG00308 Carteolol
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00308 Carteolol
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 22
1 X Cl 34.1717 -16.9041
2 C1x C 24.1844 -15.2181
3 C5x C 24.1844 -16.6229
4 N1x N 25.4010 -17.3254
5 C8y C 26.6177 -16.6229
6 C8y C 26.6177 -15.2181
7 C1x C 25.4010 -14.5157
8 C8x C 27.8343 -17.3254
9 C8x C 29.0509 -16.6229
10 C8x C 29.0509 -15.2181
11 C8y C 27.8343 -14.5157
12 O5x O 22.9678 -17.3254
13 O2a O 27.8343 -13.1108
14 C1b C 29.0530 -12.4072
15 C1c C 30.2536 -13.1006
16 C1b C 31.4445 -12.4130
17 O1a O 30.2537 -14.5154
18 N1b N 32.6401 -13.1036
19 C1d C 33.8337 -12.4145
20 C1a C 35.0333 -11.7219
21 C1a C 34.5265 -13.6153
22 C1a C 33.1223 -11.1820
BOND 22
1 2 3 1
2 3 4 1
3 4 5 1
4 5 6 1
5 6 7 1
6 2 7 1
7 5 8 2
8 8 9 1
9 9 10 2
10 10 11 1
11 6 11 2
12 3 12 2
13 11 13 1
14 13 14 1
15 14 15 1
16 15 16 1
17 15 17 1
18 16 18 1
19 18 19 1
20 19 20 1
21 19 21 1
22 19 22 1
|
|---|