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KEGG   DRUG: Voriconazole
Entry
D00578                      Drug                                   
Name
Voriconazole (JP18/USP/INN);
Vfend (TN)
  Abbr
VRC
Product
VFEND (Roerig), VFEND (Roerig), VFEND (Roerig), VORICONAZOLE (XGen Pharmaceuticals DJB), VORICONAZOLE (Xellia Pharmaceuticals USA LLC)
  Generic
VORICONAZOLE (Ajanta Pharma USA), VORICONAZOLE (Alvogen), VORICONAZOLE (American Health Packaging), VORICONAZOLE (Amneal Pharmaceuticals LLC), VORICONAZOLE (Aurobindo Pharma Limited), VORICONAZOLE (AvPAK), VORICONAZOLE (Bryant Ranch Prepack), VORICONAZOLE (Camber Pharmaceuticals), VORICONAZOLE (Civica), VORICONAZOLE (Eugia US LLC), VORICONAZOLE (Fosun Pharma USA), VORICONAZOLE (Fresenius Kabi USA), VORICONAZOLE (Gland Pharma Limited), VORICONAZOLE (Glenmark Pharmaceuticals), VORICONAZOLE (Greenstone LLC), VORICONAZOLE (Hainan Poly Pharm.), VORICONAZOLE (Lupin Pharmaceuticals), VORICONAZOLE (Lupin Pharmaceuticals), VORICONAZOLE (Major Pharmaceuticals), VORICONAZOLE (Major Pharmaceuticals), VORICONAZOLE (Mckesson Corporation DBA SKY Packaginng), VORICONAZOLE (Meitheal Pharmaceuticals), VORICONAZOLE (Mylan Institutional), VORICONAZOLE (Mylan Pharmaceuticals), VORICONAZOLE (NorthStar Rx LLC), VORICONAZOLE (Novel Laboratories), VORICONAZOLE (Sandoz), VORICONAZOLE (Sandoz), VORICONAZOLE (Slate Run Pharmaceuticals), VORICONAZOLE (Slate Run Pharmaceuticals), VORICONAZOLE (Solco Healthcare U.S.), VORICONAZOLE (UBI Pharma), VORICONAZOLE (Viona Pharmaceuticals), VORICONAZOLE (Zydus Lifesciences Limited), VORICONAZOLE (Zydus Lifesciences Limited), VORICONAZOLE (Zydus Pharmaceuticals USA)
Formula
C16H14F3N5O
Exact mass
349.1150
Mol weight
349.31
Structure
Simcomp
Class
Antifungal
 DG01523  Triazole antifungal
Metabolizing enzyme inhibitor
 DG02852  CYP3A/CYP3A4 inhibitor
Remark
Same as: C07622
Therapeutic category: 6179
ATC code: J02AC03
Product: D00578<JP/US>
Efficacy
Antifungal, Ergosterol biosynthesis inhibitor
  Disease
Invasive aspergillosis [DS:H01328]
Esophageal candidiasis [DS:H00363]
Scedosporiosis [DS:H02392]
Target
sterol 14alpha-demethylase [KO:K05917]
  Pathway
ko00100  Steroid biosynthesis
Interaction
CYP inhibition: CYP3A [HSA:1576 1577 1551]
Structure map
map07026  Antifungal agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J02 ANTIMYCOTICS FOR SYSTEMIC USE
   J02A ANTIMYCOTICS FOR SYSTEMIC USE
    J02AC Triazole and tetrazole derivatives
     J02AC03 Voriconazole
      D00578  Voriconazole (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Antifungals
  Voriconazole
   D00578  Voriconazole (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   617  Acting mainly on mold
    6179  Others
     D00578  Voriconazole (JP18/USP/INN)
Drug groups [BR:br08330]
 Antifungal
  DG01523  Triazole antifungal
   D00578  Voriconazole
 Metabolizing enzyme inhibitor
  DG02852  CYP3A/CYP3A4 inhibitor
   D00578  Voriconazole
Drug classes [BR:br08332]
 Antifungal
  DG01523  Triazole antifungal
   D00578  Voriconazole
Antimicrobials [BR:br08307]
 Antifungals
  Ergosterol biosynthesis inhibitor
   Triazole
    D00578  Voriconazole (JP18/USP/INN) <JP/US>
Antimicrobials abbreviations [BR:br08327]
 Antifungals
  Ergosterol biosynthesis inhibitor
   Triazole
    D00578  Voriconazole (JP17/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00578  Voriconazole
  D00578  Voriconazole tablets
  D00578  Voriconazole for injection
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D00578
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00578
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00578
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D00578
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00578
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D00578
Other DBs
CAS: 137234-62-9
PubChem: 7847644
ChEBI: 10023
PDB-CCD: VOR[PDBj]
LigandBox: D00578
NIKKAJI: J709.476K
KCF data

ATOM        25
            1   C1d C    25.0014  -20.8416
            2   C8y C    25.0014  -18.5274
            3   C1c C    23.8241  -21.5118
            4   C1b C    26.1673  -21.5178
            5   O1a O    25.0014  -22.1939
            6   C8y C    26.1614  -17.8513
            7   C8x C    23.8241  -17.8513
            8   C8y C    22.6232  -20.8240
            9   C1a C    23.8181  -22.8992
            10  N4y N    27.3447  -20.8357
            11  C8x C    26.1614  -16.5049
            12  X   F    27.3389  -18.5274
            13  C8x C    23.8241  -16.5049
            14  C8y C    21.4225  -21.5118
            15  N5x N    22.6349  -19.4367
            16  C8x C    27.4030  -19.4950
            17  N5x N    28.5688  -21.3895
            18  C8y C    25.0014  -15.8228
            19  C8x C    20.2216  -20.8183
            20  X   F    21.4225  -22.8992
            21  C8x C    21.4283  -18.7374
            22  N5x N    28.7960  -19.2095
            23  C8x C    29.4839  -20.3869
            24  X   F    25.0014  -14.4647
            25  N5x N    20.2216  -19.4310
BOND        27
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1 #Down
            5     2   6 2
            6     2   7 1
            7     3   8 1
            8     3   9 1 #Up
            9     4  10 1
            10    6  11 1
            11    6  12 1
            12    7  13 2
            13    8  14 1
            14    8  15 2
            15   10  16 1
            16   10  17 1
            17   11  18 2
            18   14  19 2
            19   14  20 1
            20   15  21 1
            21   16  22 2
            22   17  23 2
            23   18  24 1
            24   19  25 1
            25   13  18 1
            26   21  25 2
            27   22  23 1

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