 | | DRUG: Simvastatin | |
| Entry |
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| Name |
Simvastatin (JP18/USP/INN);
MK-733;
Zocor (TN) |
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| Product |
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| Generic |
SIMVASTATIN (A-S Medication Solutions), SIMVASTATIN (A-S Medication Solutions), SIMVASTATIN (A-S Medication Solutions), SIMVASTATIN (A-S Medication Solutions), SIMVASTATIN (A-S Medication Solutions), SIMVASTATIN (A-S Medication Solutions), SIMVASTATIN (A-S Medication Solutions), SIMVASTATIN (A-S Medication Solutions), SIMVASTATIN (A-S Medication Solutions), SIMVASTATIN (A-S Medication Solutions), SIMVASTATIN (A-S Medication Solutions), SIMVASTATIN (A-S Medication Solutions), SIMVASTATIN (A-S Medication Solutions), SIMVASTATIN (A-S Medication Solutions), SIMVASTATIN (A-S Medication Solutions), SIMVASTATIN (A-S Medication Solutions), SIMVASTATIN (Accord Healthcare), SIMVASTATIN (American Health Packaging), SIMVASTATIN (American Health Packaging), SIMVASTATIN (Aphena Pharma Solutions - Tennessee), SIMVASTATIN (Aphena Pharma Solutions - Tennessee), SIMVASTATIN (Aphena Pharma Solutions - Tennessee), SIMVASTATIN (Aphena Pharma Solutions - Tennessee), SIMVASTATIN (Aphena Pharma Solutions - Tennessee), SIMVASTATIN (Aurobindo Pharma Limited), SIMVASTATIN (Biocon Pharma Inc,), SIMVASTATIN (Bryant Ranch Prepack), SIMVASTATIN (Bryant Ranch Prepack), SIMVASTATIN (Bryant Ranch Prepack), SIMVASTATIN (Bryant Ranch Prepack), SIMVASTATIN (Bryant Ranch Prepack), SIMVASTATIN (Bryant Ranch Prepack), SIMVASTATIN (Bryant Ranch Prepack), SIMVASTATIN (Bryant Ranch Prepack), SIMVASTATIN (Bryant Ranch Prepack), SIMVASTATIN (Bryant Ranch Prepack), SIMVASTATIN (Bryant Ranch Prepack), SIMVASTATIN (Bryant Ranch Prepack), SIMVASTATIN (Bryant Ranch Prepack), SIMVASTATIN (Bryant Ranch Prepack), SIMVASTATIN (Camber Pharmaceuticals), SIMVASTATIN (Cardinal Health 107), SIMVASTATIN (Cardinal Health 107), SIMVASTATIN (Coupler LLC), SIMVASTATIN (DIRECT RX), SIMVASTATIN (Direct Rx), SIMVASTATIN (Direct_Rx), SIMVASTATIN (Direct_Rx), SIMVASTATIN (Direct_Rx), SIMVASTATIN (Dr. Reddy's Laboratories Limited), SIMVASTATIN (Legacy Pharmaceutical Packaging), SIMVASTATIN (Lupin Pharmaceuticals), SIMVASTATIN (McKesson Corporation dba SKY Packaging), SIMVASTATIN (Micro Labs Limited), SIMVASTATIN (NCS HealthCare of KY), SIMVASTATIN (NCS HealthCare of KY), SIMVASTATIN (NorthStar Rx LLC), SIMVASTATIN (Northwind Pharmaceuticals), SIMVASTATIN (Northwind Pharmaceuticals), SIMVASTATIN (Northwind Pharmaceuticals), SIMVASTATIN (Northwind Pharmaceuticals), SIMVASTATIN (Northwind Pharmaceuticals), SIMVASTATIN (Northwind Pharmaceuticals), SIMVASTATIN (Northwind Pharmaceuticals), SIMVASTATIN (NuCare Pharmaceuticals), SIMVASTATIN (NuCare Pharmaceuticals), SIMVASTATIN (NuCare Pharmaceuticals), SIMVASTATIN (NuCare Pharmaceuticals), SIMVASTATIN (NuCare Pharmaceuticals), SIMVASTATIN (NuCare Pharmaceuticals), SIMVASTATIN (NuCare Pharmaceuticals), SIMVASTATIN (NuCare Pharmaceuticals), SIMVASTATIN (NuCare Pharmaceuticals), SIMVASTATIN (NuCare Pharmaceuticals), SIMVASTATIN (NuCare Pharmaceuticals), SIMVASTATIN (NuCare Pharmaceuticals), SIMVASTATIN (NuCare Pharmaceuticals), SIMVASTATIN (NuCare Pharmaceuticals), SIMVASTATIN (PD-Rx Pharmaceuticals), SIMVASTATIN (PD-Rx Pharmaceuticals), SIMVASTATIN (PD-Rx Pharmaceuticals), SIMVASTATIN (PD-Rx Pharmaceuticals), SIMVASTATIN (PD-Rx Pharmaceuticals), SIMVASTATIN (PD-Rx Pharmaceuticals), SIMVASTATIN (PD-Rx Pharmaceuticals), SIMVASTATIN (PD-Rx Pharmaceuticals), SIMVASTATIN (Preferred Pharmaceuticals), SIMVASTATIN (Preferred Pharmaceuticals), SIMVASTATIN (Preferred Pharmaceuticals), SIMVASTATIN (Preferred Pharmaceuticals), SIMVASTATIN (Preferred Pharmaceuticals), SIMVASTATIN (Proficient Rx LP), SIMVASTATIN (Proficient Rx LP), SIMVASTATIN (Proficient Rx LP), SIMVASTATIN (Proficient Rx LP), SIMVASTATIN (Proficient Rx LP), SIMVASTATIN (Proficient Rx LP), SIMVASTATIN (PuraCap Laboratories), SIMVASTATIN (QPharma), SIMVASTATIN (QPharma), SIMVASTATIN (QPharma), SIMVASTATIN (Quallent Pharmaceuticals Health LLC), SIMVASTATIN (REMEDYREPACK), SIMVASTATIN (REMEDYREPACK), SIMVASTATIN (REMEDYREPACK), SIMVASTATIN (REMEDYREPACK), SIMVASTATIN (REMEDYREPACK), SIMVASTATIN (RPK Pharmaceuticals), SIMVASTATIN (RPK Pharmaceuticals), SIMVASTATIN (ST. MARY'S MEDICAL PARK PHARMACY), SIMVASTATIN (ST. MARY'S MEDICAL PARK PHARMACY), SIMVASTATIN (ST. MARY'S MEDICAL PARK PHARMACY), SIMVASTATIN (St Marys Medical Park Pharmacy), SIMVASTATIN (Zydus Lifesciences Limited), SIMVASTATIN (Zydus Pharmaceuticals USA) |
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| Formula |
C25H38O5
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| Exact mass |
418.2719
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| Mol weight |
418.57
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| Structure |
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| Simcomp |
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| Class |
Hypolipidemic agent
DG01946 Hypolipidemic agent
DG01660 HMG-CoA reductase inhibitor
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
Transporter substrate
DG02856 SLCO1B1 substrate
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| Remark |
| Therapeutic category: | 2189 |
| Product (mixture): | D10257<US> |
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| Efficacy |
Antihyperlipidemic, HMG-CoA reductase inhibitor |
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| Disease |
Hyperlipidemia [DS: H01635] Heterozygous familial hypercholesterolemia [DS: H00155] |
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| Comment |
mixture of Juvisync (TN)
Active form of prodrug: Simvastatin acid [CPD: C21581]
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| Target |
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| Pathway |
| hsa00900 | Terpenoid backbone biosynthesis |
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
Transporter: SLCO1B1 [HSA: 10599]
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| Interaction |
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C10 LIPID MODIFYING AGENTS
C10A LIPID MODIFYING AGENTS, PLAIN
C10AA HMG CoA reductase inhibitors
C10AA01 Simvastatin
D00434 Simvastatin (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Cardiovascular Agents
Dyslipidemics, HMG CoA Reductase Inhibitors
Simvastatin
D00434 Simvastatin (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
218 Hyperlipidemia agents
2189 Others
D00434 Simvastatin (JP18/USP/INN)
Drug groups [BR:br08330]
Hypolipidemic agent
DG01946 Hypolipidemic agent
DG01660 HMG-CoA reductase inhibitor
D00434 Simvastatin
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
D00434 Simvastatin
Transporter substrate
DG02856 SLCO1B1 substrate
D00434 Simvastatin
Drug classes [BR:br08332]
Cardiovascular agent
DG01946 Hypolipidemic agent
D00434 Simvastatin
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Dehydrogenases
HMGCR
D00434 Simvastatin (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00434 Simvastatin
D00434 Simvastatin tablets
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00434
Drug transporters
D00434
Prodrugs [br08324.html]
D00434
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| Other DBs |
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| KCF data |
ATOM 30
1 C1y C 19.2474 -18.6526
2 C1y C 18.0208 -17.9416
3 C2y C 19.2415 -20.0690
4 C1y C 20.4741 -17.9476
5 O7a O 18.0208 -16.5254
6 C1x C 16.7882 -18.6526
7 C2x C 20.4622 -20.7862
8 C2x C 18.0208 -20.7801
9 C1b C 20.4801 -16.5312
10 C1y C 21.7008 -18.6646
11 C7a C 16.7941 -15.8142
12 C1y C 16.7882 -20.0690
13 C2x C 21.6950 -20.0809
14 C1d C 15.5674 -16.5254
15 O6a O 16.8001 -14.3977
16 C1a C 15.5615 -20.7801
17 C1b C 14.3406 -15.8142
18 C1a C 16.0356 -17.4793
19 C1a C 14.8248 -17.5491
20 C1a C 13.1140 -16.5194
21 C1a C 22.9237 -17.9663
22 C1b C 21.6950 -15.8392
23 C1y C 21.7333 -14.4397
24 O7x O 22.9478 -13.7290
25 C7x C 22.9396 -12.3297
26 C1x C 21.7236 -11.6371
27 C1y C 20.5558 -12.3479
28 C1x C 20.5639 -13.7472
29 O1a O 19.3289 -11.6357
30 O6a O 24.1539 -11.6188
BOND 32
1 1 2 1
2 1 3 1
3 1 4 1
4 2 5 1 #Down
5 2 6 1
6 3 7 1
7 3 8 2
8 4 9 1 #Up
9 4 10 1
10 5 11 1
11 6 12 1
12 7 13 2
13 11 14 1
14 11 15 2
15 12 16 1 #Down
16 14 17 1
17 14 18 1
18 14 19 1
19 17 20 1
20 8 12 1
21 10 13 1
22 10 21 1 #Up
23 9 22 1
24 23 22 1 #Down
25 23 24 1
26 24 25 1
27 25 26 1
28 26 27 1
29 27 28 1
30 23 28 1
31 27 29 1 #Up
32 25 30 2
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