 | | DRUG: Glyburide | |
| Entry |
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| Name |
Glyburide (USP);
Glibenclamide (JP18/INN);
Diabeta (TN);
Glynase (TN);
Micronase (TN) |
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| Product |
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| Generic |
GLYBURIDE (A-S Medication Solutions), GLYBURIDE (A-S Medication Solutions), GLYBURIDE (A-S Medication Solutions), GLYBURIDE (A-S Medication Solutions), GLYBURIDE (A-S Medication Solutions), GLYBURIDE (Bryant Ranch Prepack), GLYBURIDE (Bryant Ranch Prepack), GLYBURIDE (Cadila Pharmaceuticals Limited), GLYBURIDE (Chartwell RX), GLYBURIDE (Coupler LLC), GLYBURIDE (Coupler LLC), GLYBURIDE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), GLYBURIDE (Modavar Pharmaceuticals LLC), GLYBURIDE (Nivagen Pharmaceuticals), GLYBURIDE (Northwind Pharmaceuticals), GLYBURIDE (Northwind Pharmaceuticals), GLYBURIDE (NuCare Pharmaceuticals), GLYBURIDE (NuCare Pharmaceuticals), GLYBURIDE (NuCare Pharmaceuticals), GLYBURIDE (NuCare Pharmaceuticals), GLYBURIDE (NuCare Pharmaceuticals), GLYBURIDE (NuCare Pharmaceuticals), GLYBURIDE (NuCare Pharmaceuticals), GLYBURIDE (NuCare Pharmaceuticals), GLYBURIDE (NuCare Pharmaceuticals), GLYBURIDE (NuCare Pharmaceuticals), GLYBURIDE (NuCare Pharmaceuticals), GLYBURIDE (NuCare Pharmaceuticals), GLYBURIDE (Preferred Pharmaceuticals), GLYBURIDE (Preferred Pharmaceuticals), GLYBURIDE (Proficient Rx LP), GLYBURIDE (Proficient Rx LP), GLYBURIDE (Proficient Rx LP), GLYBURIDE (Proficient Rx LP), GLYBURIDE (REMEDYREPACK), GLYBURIDE (REMEDYREPACK), GLYBURIDE (REMEDYREPACK), GLYBURIDE (RPK Pharmaceuticals), GLYBURIDE (RPK Pharmaceuticals), GLYBURIDE (TEVA Pharmaceuticals USA), GLYBURIDE (Teva Pharmaceuticals USA), GLYBURIDE (Teva Pharmaceuticals USA), GLYBURIDE (Zydus Lifesciences Limited), GLYBURIDE (Zydus Pharmaceuticals (USA)) |
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| Formula |
C23H28ClN3O5S
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| Exact mass |
493.1438
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| Mol weight |
494.00
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| Structure |
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| Simcomp |
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| Class |
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| Remark |
| Therapeutic category: | 3961 |
| Product (mixture): | D10266<US> |
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| Efficacy |
Antidiabetic, Hypoglycemic |
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| Disease |
Type 2 diabetes mellitus [DS: H00409] |
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| Comment |
Sulfonylurea
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| Target |
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| Pathway |
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| Metabolism |
Enzyme: CYP2C9 [HSA: 1559], CYP3A4 [HSA: 1576]
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| Interaction |
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| Structure map |
| map07018 | Sulfonamide derivatives - hypoglycemic agents |
| map07232 | Potassium channel blocking and opening drugs |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A10 DRUGS USED IN DIABETES
A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
A10BB Sulfonylureas
A10BB01 Glibenclamide
D00336 Glyburide (USP) <JP/US>
USP drug classification [BR:br08302]
Blood Glucose Regulators
Antidiabetic Agents
Sulfonylureas
Glyburide
D00336 Glyburide (USP)
Therapeutic category of drugs in Japan [BR:br08301]
3 Agents affecting metabolism
39 Other agents affecting metabolism
396 Antidiabetic agents
3961 Sulfonylureas
D00336 Glyburide (USP); Glibenclamide (JP18/INN)
Drug groups [BR:br08330]
Antidiabetic agent
DG01508 Sulfonylurea receptor agonist
DG01734 Sulfonylurea
D00336 Glyburide
DG02044 Hypoglycemic agent
DG01734 Sulfonylurea
D00336 Glyburide
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
D00336 Glyburide
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
D00336 Glyburide
Drug classes [BR:br08332]
Antidiabetic agent
DG01734 Sulfonylurea
D00336 Glyburide
DG02044 Hypoglycemic agent
D00336 Glyburide
Target-based classification of drugs [BR:br08310]
Transporters
ABC transporters
ABCC subfamily
ABCC8(SUR1)/KCNJ11(KIR6.2)
D00336 Glyburide (USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00336 Glibenclamide
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D00336
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00336
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
D00336
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| Other DBs |
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| KCF data |
ATOM 33
1 C8y C 7.5600 -22.0500
2 C8y C 7.5600 -23.4500
3 C8x C 6.3700 -21.2800
4 C5a C 8.7500 -21.3500
5 C8x C 6.3700 -24.0800
6 O2a O 8.7500 -24.1500
7 C8y C 5.1100 -21.9800
8 N1b N 9.9400 -22.0500
9 O5a O 8.7500 -19.9500
10 C8x C 5.1100 -23.3800
11 C1a C 8.7500 -25.4800
12 X Cl 3.9200 -21.2800
13 C1b C 11.2000 -21.3500
14 C1b C 12.3900 -22.0500
15 C8y C 13.5800 -21.3500
16 C8x C 13.5800 -19.9500
17 C8x C 14.7700 -22.0500
18 C8x C 14.7700 -19.2500
19 C8x C 16.0300 -21.3500
20 C8y C 16.0300 -19.9500
21 S4a S 17.2200 -19.2500
22 N1b N 18.4100 -19.9500
23 C5a C 19.6000 -19.2500
24 N1b N 20.8600 -19.9500
25 O5a O 19.6000 -17.8500
26 C1y C 22.0500 -19.2500
27 C1x C 22.0500 -17.8500
28 C1x C 23.2400 -19.9500
29 C1x C 23.2400 -17.1500
30 C1x C 24.4300 -19.2500
31 C1x C 24.4300 -17.8500
32 O3c O 17.9200 -18.0376
33 O3c O 16.5200 -18.0376
BOND 35
1 1 2 1
2 1 3 2
3 1 4 1
4 2 5 2
5 2 6 1
6 3 7 1
7 4 8 1
8 4 9 2
9 5 10 1
10 6 11 1
11 7 12 1
12 8 13 1
13 13 14 1
14 14 15 1
15 15 16 2
16 15 17 1
17 16 18 1
18 17 19 2
19 18 20 2
20 20 21 1
21 21 22 1
22 22 23 1
23 23 24 1
24 23 25 2
25 24 26 1
26 26 27 1
27 26 28 1
28 27 29 1
29 28 30 1
30 29 31 1
31 7 10 2
32 19 20 1
33 30 31 1
34 21 32 2
35 21 33 2
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