| Entry |
|
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| Name |
Flunisolide (JAN/USP);
Aerospan (TN);
Nasalide (TN) |
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| Product |
|
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| Generic |
|
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| Formula |
(C24H31FO6)2. H2O
|
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| Exact mass |
886.4315
|
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| Mol weight |
887.01
|
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| Structure |
|
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| Class |
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
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| Remark |
| Product (DG01040): | D00324<US> |
|
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| Efficacy |
Anti-inflammatory, Glucocorticoid receptor agonist |
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| Disease |
|
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| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
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| Interaction |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
R01 NASAL PREPARATIONS
R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
R01AD Corticosteroids
R01AD04 Flunisolide
D00324 Flunisolide (JAN/USP) <US>
R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
R03B OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
R03BA Glucocorticoids
R03BA03 Flunisolide
D00324 Flunisolide (JAN/USP) <US>
USP drug classification [BR:br08302]
Respiratory Tract/Pulmonary Agents
Anti-inflammatories, Inhaled Corticosteroids
Flunisolide
D00324 Flunisolide (JAN/USP)
Risk category of Japanese OTC drugs [BR:br08312]
Designated second-class OTC drugs
Inorganic and organic chemicals
Flunisolide
D00324 Flunisolide (JAN/USP)
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG01040 Flunisolide
D00324 Flunisolide
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG01040 Flunisolide
D00324 Flunisolide
Drug classes [BR:br08332]
Anti-inflammatory
DG01955 Corticosteroid
D00324 Flunisolide
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C1 (GR)
D00324 Flunisolide (JAN/USP) <US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00324
Rx-to-OTC switch list in Japan [br08314.html]
D00324
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG01040 Flunisolide
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG01040 Flunisolide
|
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| Other DBs |
|
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| KCF data |
ATOM 63
1 O0 O 35.9800 -28.5600
2 C2x C 19.6000 -29.2600
3 C5x C 19.6000 -30.5900
4 C2x C 20.7900 -31.2900
5 C2y C 21.9800 -30.5900
6 C1z C 21.9800 -29.2600
7 C2x C 20.7900 -28.5600
8 C1y C 23.1700 -31.2900
9 C1x C 24.3600 -30.5900
10 C1y C 24.3600 -29.2600
11 C1y C 23.1700 -28.5600
12 C1y C 25.4800 -28.5600
13 C1z C 25.4800 -27.2300
14 C1x C 24.3600 -26.5300
15 C1y C 23.1700 -27.2300
16 C1x C 27.8600 -28.5600
17 C1y C 27.8600 -27.2300
18 C1z C 26.6700 -26.5300
19 O5x O 18.4800 -31.2900
20 C1a C 21.9800 -27.8600
21 O1a O 21.9800 -26.5300
22 C1a C 25.4800 -25.8300
23 C5a C 26.6700 -24.9200
24 O2x O 28.0700 -25.6200
25 O5a O 27.8600 -24.2200
26 C1b C 25.4800 -24.2200
27 O1a O 24.3600 -24.9200
28 O2x O 29.2600 -27.2300
29 C1z C 29.4700 -25.6200
30 C1a C 30.8700 -25.6200
31 C1a C 29.4700 -24.2200
32 X F 23.1700 -32.6900
33 C2x C 19.6000 -29.2600
34 C5x C 19.6000 -30.5900
35 C2x C 20.7900 -31.2900
36 C2y C 21.9800 -30.5900
37 C1z C 21.9800 -29.2600
38 C2x C 20.7900 -28.5600
39 C1y C 23.1700 -28.5600
40 C1y C 24.3600 -29.2600
41 C1x C 24.3600 -30.5900
42 C1y C 23.1700 -31.2900
43 X F 23.1700 -32.6900
44 C1y C 25.4800 -28.5600
45 C1z C 25.4800 -27.2300
46 C1x C 24.3600 -26.5300
47 C1y C 23.1700 -27.2300
48 O1a O 21.9800 -26.5300
49 C1z C 26.6700 -26.5300
50 C1y C 27.8600 -27.2300
51 C1x C 27.8600 -28.5600
52 O2x O 29.2600 -27.2300
53 C1z C 29.4700 -25.6200
54 O2x O 28.0700 -25.6200
55 C1a C 30.8700 -25.6200
56 C1a C 29.4700 -24.2200
57 C5a C 26.6700 -24.9200
58 O5a O 27.8600 -24.2200
59 C1b C 25.4800 -24.2200
60 O1a O 24.3600 -24.9200
61 C1a C 25.4800 -25.8300
62 C1a C 21.9800 -27.8600
63 O5x O 18.4800 -31.2900
BOND 70
1 2 3 1
2 3 4 1
3 4 5 2
4 5 6 1
5 6 7 1
6 2 7 2
7 5 8 1
8 8 9 1
9 9 10 1
10 10 11 1
11 6 11 1
12 10 12 1
13 12 13 1
14 13 14 1
15 14 15 1
16 11 15 1
17 12 16 1
18 16 17 1
19 17 18 1
20 13 18 1
21 3 19 2
22 6 20 1 #Up
23 15 21 1 #Up
24 13 22 1 #Up
25 18 23 1 #Up
26 18 24 1 #Down
27 23 25 2
28 23 26 1
29 26 27 1
30 17 28 1 #Down
31 24 29 1
32 29 28 1
33 29 30 1
34 29 31 1
35 8 32 1 #Down
36 33 34 1
37 34 35 1
38 35 36 2
39 36 37 1
40 37 38 1
41 33 38 2
42 36 42 1
43 42 41 1
44 41 40 1
45 40 39 1
46 37 39 1
47 40 44 1
48 44 45 1
49 45 46 1
50 46 47 1
51 39 47 1
52 44 51 1
53 51 50 1
54 50 49 1
55 45 49 1
56 34 63 2
57 37 62 1 #Up
58 47 48 1 #Up
59 45 61 1 #Up
60 49 57 1 #Up
61 49 54 1 #Down
62 57 58 2
63 57 59 1
64 59 60 1
65 50 52 1 #Down
66 54 53 1
67 53 52 1
68 53 55 1
69 53 56 1
70 42 43 1 #Down
BRACKET 1 17.2200 -33.6700 17.2200 -23.0300
1 32.8300 -23.0300 32.8300 -33.6700
1 2
ORIGINAL 1 2 3 4 5 6 7 11 10 9 8 35 12 13 14 15 23
1 18 17 16 31 32 27 33 34 26 28 29 30 25 24 22 21
1 20 19
REPEAT 1 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51
1 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67
1 68 69
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