 | | DRUG: Piroxicam | |
| Entry |
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| Name |
Piroxicam (JP18/USP/INN);
Feldene (TN) |
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| Product |
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| Generic |
PIROXICAM (AvKARE), PIROXICAM (AvKARE), PIROXICAM (Bryant Ranch Prepack), PIROXICAM (Bryant Ranch Prepack), PIROXICAM (Bryant Ranch Prepack), PIROXICAM (Bryant Ranch Prepack), PIROXICAM (Bryant Ranch Prepack), PIROXICAM (Bryant Ranch Prepack), PIROXICAM (Bryant Ranch Prepack), PIROXICAM (Bryant Ranch Prepack), PIROXICAM (Direct_Rx), PIROXICAM (Greenstone LLC), PIROXICAM (Micro Labs Limited), PIROXICAM (Nostrum Laboratories), PIROXICAM (PD-Rx Pharmaceuticals), PIROXICAM (Proficient Rx LP), PIROXICAM (Proficient Rx LP), PIROXICAM (Proficient Rx LP), PIROXICAM (Strides Pharma Science Limited), PIROXICAM (Teva Pharmaceuticals USA), PIROXICAM (Unichem Pharmaceuticals (USA)), PIROXICAM (Vensun Pharmaceuticals), PIROXICAM (Zydus Lifesciences Limited) |
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| Formula |
C15H13N3O4S
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| Exact mass |
331.0627
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| Mol weight |
331.35
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| Structure |
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| Simcomp |
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| Class |
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01910 Anti-inflammatory drug, oxicams
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
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| Remark |
| Product (DG00752): | D00127<JP/US> |
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| Efficacy |
Analgesic, Anti-inflammatory, Antirheumatic, COX inhibitor |
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| Disease |
Rheumatoid arthritis [DS: H00630] |
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| Comment |
Oxicams
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| Target |
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| Pathway |
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| Metabolism |
Enzyme: CYP2C9 [HSA: 1559]
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| Interaction |
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
M MUSCULO-SKELETAL SYSTEM
M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
M01AC Oxicams
M01AC01 Piroxicam
D00127 Piroxicam (JP18/USP/INN) <JP/US>
M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
M02AA Antiinflammatory preparations, non-steroids for topical use
M02AA07 Piroxicam
D00127 Piroxicam (JP18/USP/INN) <JP/US>
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01B ANTIINFLAMMATORY AGENTS
S01BC Antiinflammatory agents, non-steroids
S01BC06 Piroxicam
D00127 Piroxicam (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Analgesics
Nonsteroidal Anti-inflammatory Drugs
Piroxicam
D00127 Piroxicam (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
114 Antipyretics and analgesics, anti-inflammatory agents
1149 Others
D00127 Piroxicam (JP18/USP/INN)
2 Agents affecting individual organs
26 Epidermides
264 Analgesics, anti-itchings, astringents, anti-inflammatory agents
2649 Others
D00127 Piroxicam (JP18/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
Agents for integumentary system
57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
D00127 Piroxicam (JP18/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
Second-class OTC drugs
Inorganic and organic chemicals
Piroxicam
D00127 Piroxicam (JP18/USP/INN)
Drug groups [BR:br08330]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01910 Anti-inflammatory drug, oxicams
DG00752 Piroxicam
D00127 Piroxicam
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG00752 Piroxicam
D00127 Piroxicam
Drug classes [BR:br08332]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
D00127 Piroxicam
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Prostaglandin synthase
PTGS1 (COX1)
D00127 Piroxicam (JP18/USP/INN) <JP/US>
PTGS2 (COX2)
D00127 Piroxicam (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00127 Piroxicam
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00127
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
D00127
Prodrugs [br08324.html]
D00127
Rx-to-OTC switch list in Japan [br08314.html]
D00127
Drug groups [BR:br08330]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01910 Anti-inflammatory drug, oxicams
DG00752 Piroxicam
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG00752 Piroxicam
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| Other DBs |
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| KCF data |
ATOM 23
1 C8y C 21.6417 -19.0786
2 C8y C 21.6417 -20.4557
3 C8y C 22.8309 -18.3776
4 C8x C 20.4462 -18.3965
5 S2x S 22.8434 -21.1442
6 C8x C 20.4462 -21.1504
7 C8y C 24.0327 -19.0724
8 O1a O 22.8247 -17.0194
9 C8x C 19.2695 -19.0786
10 N4y N 23.9752 -20.4619
11 O3c O 21.2912 -22.1144
12 O3c O 24.2329 -22.0643
13 C8x C 19.2695 -20.4557
14 C5a C 25.2092 -18.3840
15 C1a C 25.2218 -21.1378
16 O5a O 25.2031 -17.0257
17 N1b N 26.3932 -19.0594
18 C8y C 27.5703 -18.3716
19 N5x N 28.7479 -19.0436
20 C8x C 29.9249 -18.3558
21 C8x C 29.9178 -16.9927
22 C8x C 28.7338 -16.3171
23 C8x C 27.5569 -17.0049
BOND 25
1 3 8 1
2 4 9 2
3 5 10 1
4 5 11 2
5 5 12 2
6 6 13 2
7 7 14 1
8 10 15 1
9 14 16 2
10 7 10 1
11 9 13 1
12 14 17 1
13 1 2 2
14 17 18 1
15 1 3 1
16 1 4 1
17 2 5 1
18 2 6 1
19 3 7 2
20 18 19 2
21 19 20 1
22 20 21 2
23 21 22 1
24 22 23 2
25 23 18 1
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