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KEGG   NETWORK: N01858
Entry
N01858                      Network                                
Name
EFNB1-MAPT axon guidance signaling
Definition
EFNB1 -> EPHB2 -> PI3K -> PIP3 -> AKT -| GSK3B -> MAPT == (TUBA+TUBB)
  Expanded
1947 -> 2048 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -| 2932 -> 4137 == ((7846,10376,84790,7278,113457,112714,7277,51807)+(203068,81027,7280,347733,10381,10382,10383,84617,347688))
Class
nt06541 Cytoskeleton in neurons
Type
Reference
Gene
1947  EFNB1; ephrin B1
2048  EPHB2; EPH receptor B2
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
2932  GSK3B; glycogen synthase kinase 3 beta
4137  MAPT; microtubule associated protein tau
7846  TUBA1A; tubulin alpha 1a
10376  TUBA1B; tubulin alpha 1b
84790  TUBA1C; tubulin alpha 1c
7278  TUBA3C; tubulin alpha 3c
113457  TUBA3D; tubulin alpha 3d
112714  TUBA3E; tubulin alpha 3e
7277  TUBA4A; tubulin alpha 4a
51807  TUBA8; tubulin alpha 8
203068  TUBB; tubulin beta class I
81027  TUBB1; tubulin beta 1 class VI
7280  TUBB2A; tubulin beta 2A class IIa
347733  TUBB2B; tubulin beta 2B class IIb
10381  TUBB3; tubulin beta 3 class III
10382  TUBB4A; tubulin beta 4A class IVa
10383  TUBB4B; tubulin beta 4B class IVb
84617  TUBB6; tubulin beta 6 class V
347688  TUBB8; tubulin beta 8 class VIII
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:34924953
  Authors
Sanchez-Huertas C, Herrera E
  Title
With the Permission of Microtubules: An Updated Overview on Microtubule Function During Axon Pathfinding.
  Journal
Front Mol Neurosci 14:759404 (2021)
DOI:10.3389/fnmol.2021.759404
Reference
PMID:26119563
  Authors
Jiang J, Wang ZH, Qu M, Gao D, Liu XP, Zhu LQ, Wang JZ
  Title
Stimulation of EphB2 attenuates tau phosphorylation through PI3K/Akt-mediated inactivation of glycogen synthase kinase-3beta.
  Journal
Sci Rep 5:11765 (2015)
DOI:10.1038/srep11765
Reference
PMID:33675023
  Authors
Zhang L, Qi Z, Li J, Li M, Du X, Wang S, Zhou G, Xu B, Liu W, Xi S, Xu Z, Deng Y
  Title
Roles and Mechanisms of Axon-Guidance Molecules in Alzheimer's Disease.
  Journal
Mol Neurobiol 58:3290-3307 (2021)
DOI:10.1007/s12035-021-02311-2

  All links  
Chemical substance (1)   
   KEGG COMPOUND (1)   
Gene (27)   
   KEGG GENES (27)   
Literature (3)   
   PubMed (3)   
All databases (31)   

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